Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs

Vieira, Eveline Bis; Menescal-de-Oliveira, Leda; Leite–Panissi, Christie Ramos Andrade

doi:10.1016/j.bbr.2010.07.013

Cited by 35 publications

(17 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Once the TI episode is elicited, it triggers an intense c‐Fos immunoreactivity in mesencephalic regions, including the different PAG subdivisions (Vieira et al . ), corroborating the role of this structure in the defensive behavioural response in guinea‐pigs (Monassi et al . , Ramos Coutinho et al .…”

supporting

confidence: 80%

See 1 more Smart Citation

Pro‐inflammatory cytokines, IL‐1β and TNF‐α, produce persistent compromise in tonic immobility defensive behaviour in endotoxemia guinea‐pigs

et al. 2016

View full text Add to dashboard Cite

show abstract

supporting

confidence: 80%

“…, Vieira et al . , Eidson & Murphy ). In the present study, we found a rapid increase in the number of neurones expressing c‐Fos protein at the both columns of PAG, dorsal and ventrolateral, suggesting the participation of this brain structure in behavioural adaptations in endotoxemic guinea‐pigs.…”

Section: Discussionmentioning

confidence: 96%

Pro‐inflammatory cytokines, IL‐1β and TNF‐α, produce persistent compromise in tonic immobility defensive behaviour in endotoxemia guinea‐pigs

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In effect, tonic immobility may be conceptualized as a fight‐or‐flight response put on hold through the activation of a “braking” mechanism that results in the immobilization of motor pathways via striatal inhibition (Jhou, Fields, Baxter, Saper, & Holland, ; Vieira‐Rasteli, Paula, Paiva, Coimbra, & Leite‐Panissi, ). Here, the “braking” mechanism is thought to be coordinated by activation of the ventrolateral subunit of the periaqueductal gray in humans and animals alike (De Oca et al, ; Miranda‐Páez, Zamudio, Vázquez‐León, Campos‐Rodríguez, & Ramírez‐San Juan, ; Mobbs et al, ; Monassi, Ramos Andrade Leite‐Panissi, & Menescal‐de‐Oliveira, ; Vieira, Menescal‐de‐Oliveira, & Leite‐Panissi, ; Walker & Carrive, ; for a review, see Kozlowska et al, ) (Figure ).…”

Section: Tonic Immobilitymentioning

confidence: 99%

The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray

Terpou

Harricharan

McKinnon

et al. 2019

J of Neuroscience Research

View full text Add to dashboard Cite

Post-traumatic stress disorder (PTSD), a diagnosis that may follow the experience of trauma, has multiple symptomatic phenotypes. Generally, individuals with PTSD display symptoms of hyperarousal and of hyperemotionality in the presence of fearful stimuli. A subset of individuals with PTSD; however, elicit dissociative symptomatology (i.e., depersonalization, derealization) in the wake of a perceived threat. This pattern of response characterizes the dissociative subtype of the disorder, which is often associated with emotional numbing and hypoarousal. Both symptomatic phenotypes exhibit attentional threat biases, where threat stimuli are processed preferentially leading to a hypervigilant state that is thought to promote defensive behaviors during threat processing. Accordingly, PTSD and its dissociative subtype are thought to differ in their proclivity to elicit active (i.e., fight, flight) versus passive (i.e., tonic immobility, emotional shutdown) defensive responses, which are characterized by the increased and the decreased expression of the sympathetic nervous system, respectively. Moreover, active and passive defenses are accompanied by primarily endocannabinoid-and opioid-mediated analgesics, respectively. Through critical review of the literature, we apply the defense cascade model to better understand the pathological presentation of defensive responses in PTSD with a focus on the functioning of lower-level midbrain and extended brainstem systems. K E Y W O R D Sbrainstem, dissociation, periaqueductal gray, PTSD, trauma | INTRODUC TI ONIn this review, we integrate literature from trauma experiences, the defense cascade, and the threat-response neurocircuitry within a framework of post-traumatic stress disorder (PTSD). We begin by introducing the concepts of the hypothalamic-pituitary-adrenal (HPA) axis, general PTSD, and defensive responses. Following these primers, we discuss the influences of trauma onset and prolonged exposure to trauma and their effects on the development of PTSD and the dissociative subtype of PTSD. Next, we introduce the defense cascade model and its underlying neurocircuitry as described in the animal literature and relate it to PTSD. In addition, we discuss the current state of the neuroimaging literature, which Edited by Sandra Chanraud.All peer review communications can be found with the online version of the article. | 1111TERPOU ET al. suggests that functional alterations are detectable in the midbrain of individuals with PTSD and its dissociative subtype as compared to healthy controls. We conclude by presenting directions for future research and the clinical implications for treatment of persons with PTSD that arise from this review of the extant literature.

show abstract

“…Recent studies showed that TI behavior increases the neural activity in the PAG (Vieira et al, 2011) and is dependent on vlPAG mechanisms (Monassi et al, 1994; Leite-Panissi et al, 2001). Thus, both inflammation and pain control are part of the innate behavioral defense repertoire to aversive, life-threatening, stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, both inflammation and pain control are part of the innate behavioral defense repertoire to aversive, life-threatening, stimuli. Noteworthy, TI in animals is related with the gradual activation of different brain structures involved with neurovegetative, motor, and cognitive responses (Carli, 1968; Klemm, 1971; Leite-Panissi et al, 2001; Leite-Panissi and Menescal-de-Oliveira, 2002; Vieira et al, 2011). Thus, the progressive anti-inflammatory effect induced during TI in guinea pigs can be due to the gradual and cumulative stimulation of different brain areas controlling pain and inflammation, such as the LC, PVN, and PAG.…”

Section: Discussionmentioning

confidence: 99%

Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions

et al. 2018

View full text Add to dashboard Cite

Inflammation and pain are major clinical burdens contributing to multiple disorders and limiting the quality of life of patients. We previously reported that brain electrical stimulation can attenuate joint inflammation in experimental arthritis. Here, we report that non-aversive electrical stimulation of the locus coeruleus (LC), the paraventricular hypothalamic nucleus (PVN) or the ventrolateral column of the periaqueductal gray matter (vlPAG) decreases thermal pain sensitivity, knee inflammation and synovial neutrophilic infiltration in rats with intra-articular zymosan. We also analyzed the modulation of pain and inflammation during aversive neuronal stimulation, which produces defensive behavioral responses such as freezing immobility to avoid predator detection. Electrical stimulation with higher intensity to induce freezing immobility in rats further reduces pain but not inflammation. However, tonic immobility further reduces pain, knee inflammation and synovial neutrophilic infiltration in guinea pigs. The duration of the tonic immobility increases the control of pain and inflammation. These results reveal survival behavioral and neuromodulatory mechanisms conserved in different species to control pain and inflammation in aversive life-threatening conditions. Our results also suggest that activation of the LC, PVN, or vlPAG by non-invasive methods, such as physical exercise, meditation, psychological interventions or placebo treatments may reduce pain and joint inflammation in arthritis without inducing motor or behavioral alterations.

show abstract

Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs

Cited by 35 publications

References 65 publications

Pro‐inflammatory cytokines, IL‐1β and TNF‐α, produce persistent compromise in tonic immobility defensive behaviour in endotoxemia guinea‐pigs

Pro‐inflammatory cytokines, IL‐1β and TNF‐α, produce persistent compromise in tonic immobility defensive behaviour in endotoxemia guinea‐pigs

The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray

Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions

Contact Info

Product

Resources

About