Functional Materials for Bone Regeneration from Beta‐Tricalcium Phosphate

Abstract

Biodegradable ceramics of b-tricalcium phosphate (b-TCP, Ca 3 (PO 4 ) 2 ) are widely used as bone regeneration materials. The goal is a complete regeneration of the bony defect (restitutio ad integrum = full recovery). Different bioceramics made of b-TCP show fundamental differences in terms of phase purity, primary particle size, stability, porosity, solubility and therefore biodegradation of the material. Cerasorb J is a bioceramic consisting of phase pure b-TCP. The primary particle size in connection with a stable sinter structure forms a porous biomaterial which is optimised in the functional surface, porosity and resorption/degradation behaviour. Different forms of Cerasorb J are available: granular materials with high and low porosity optimised for specific indications as well as block forms shapeable by the surgeon for various bony defects.Keywords

Numerical computation of the porosity of bone substitution materials from synchrotron micro computer tomographic data

“…The microporosity (<50 lm) is about 20AE5 %, the macroporosity (drilled cylindrical pores with a diameter 1-2 mm) is about 24-57 %. The total porosity is about 47-66 % [5,29].…”

Effect of β-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans

“…In recent years, the use of tricalcium phosphate (TCP) particles as alloplastic bone graft materials for sinus floor elevation procedures has received increasing attention in implant dentistry [4,7e10]. More recently, the use of TCP particles with increased porosity has been promoted in order to increase the biodegradability [11,12]. These particles exhibit a material structure with micro-, meso-and macropores, which is designed to enhance the degradation process.…”

“…The interconnectivity of the pores creates a capillary force that actively draws cells and nutrients in the center of the particles. The macroporosity is created to encourage the ingrowth of bone by permitting penetration of cells and vascularization [11].…”

X‐ray powder diffraction data of synthetic β‐Tricalcium Phosphate

“…Also, a continuous high phase purity of b-TCP bone augmentation materials in different batches is a sign for a reproducible manufacturing quality and therefore preferable [7], [8]. For measurements of b-TCP biomaterials an adequate reference is recommended.…”