Functional Mechanism of the Labyrinthine Epithelium: II. Author's Theory

Mygind, S. H.

doi:10.1001/archotol.1965.00760010581005

Cited by 6 publications

(5 citation statements)

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“…According to the early published works [10,[16][17][18][19] the endolymph consists of the acid mucopolysaccharide molecules, which are considered as the long threads of the length about 0.5 mkm and the width about 4 nm. One of them most imported features is that they are getting polarized, being bent by the hits of surrounding water molecules submitted to the Brownian motion.…”

Section: Molecular Sensorsmentioning

confidence: 99%

On the molecular filters in cochlea transduction

Goussev

2018

Preprint

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The article is devoted to the specific consideration of the cochlear transduction for the low level sound intensities, which correspond to the regions near the perception threshold. The basic cochlea mechanics is extended by the new concept of the molecular filters, which allows us to discuss the transduction mechanism on the molecular level in the space-time domain. The molecular filters are supposed to be built on the set of the stereocilia of every inner hair cell. It is hypothesized that the molecular filters are the sensors in the feedback loop, which includes also outer hair cells along with the tectorial membrane and uses the zero compensation method to evaluate the traveling wave shape on the basilar membrane. Besides the compensation, the feedback loop, being spatially distributed along the cochlea, takes control over the tectorial membrane strain field generated by the outer hair cells, and implements it as the mechanism for the automatic gain control in the sound transduction.

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Section: Molecular Sensorsmentioning

confidence: 99%

On the molecular filters in cochlea transduction

Goussev

2018

Preprint

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“…According to the earlier published works (Jensen, 1954;Jensen, Koefoed, & Vilstrup, 1954;Carlsen, Dansgaard, & Jensen, 1959;Christiansen, 1963;Mygin, 1965) the endolymph consists of the acid mucopolysaccharide molecules, which are considered as the long threads of the length about 0.5 mkm and the width about 4 nm. One of them most imported features is that they are getting polarized, being bent by the hits of surrounding water molecules submitted to the Brownian motion.…”

Section: Molecular Sensorsmentioning

confidence: 99%

On the Molecular Filters in Cochlea Transduction

Goussev¹

2018

IJB

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The article is devoted to the specific consideration of the cochlear transduction for the low level sound intensities, which correspond to the regions near the perception threshold. The basic cochlea mechanics is extended by the new concept of the molecular filters, which allows discussing the transduction mechanism on the molecular level in the space-time domain. The molecular filters are supposed to be built on the set of the stereocilia of every inner hair cell. It is hypothesized that the molecular filters are the sensors in the feedback loop, which includes also outer hair cells along with the tectorial membrane and uses the zero compensation method to evaluate the traveling wave shape on the basilar membrane. Besides the compensation, the feedback loop, being spatially distributed along the cochlea, takes control over the tectorial membrane strain field generated by the outer hair cells, and implements it as the mechanism for the automatic gain control in the sound transduction.

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“…This was written in 1966; however, the lesson was not heeded, for the publication of ill-informed theories of hearing still continues. The reason for von Bekesy's comments was a series of papers by Mygind (1966), who studied a large amount of fixed material of various ages and conditions derived from a wide variety of animal species. He concluded that a pressure receptor rather than a shearing force was the meaningful stimulus and that certain structures, e.g.…”

Section: Mechanics Of the Cochleamentioning

confidence: 99%

The peripheral auditory apparatus

Johnstone

Sellick

1972

Quart. Rev. Biophys.

125

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This review of the peripheral auditory apparatus represents an attempt to analyse critically recent developments in the field. The coverage is not exhaustive, the emphasis is on functional aspects and no attempt is made to review the anatomy of the ear. Particular emphasis is placed on three broad sections: the physiology of the middle ear, basilar membrane mechanics and the electrophysiology of the cochlea. It is in these areas that recent technical advances have led to experiments which throw doubt on traditionally held concepts. Such an advance is the application of the Mössbauer technique to the problem of middle- and inner-ear mechanics. Because of its novelty, this technique is discussed in detail. Other new methods such as laser holography are just starting to be used, as are the ion selective microelectrodes for measuring dynamic changes in endolymph concentration. After many years of slow progress there is a sudden spark of enthusiasm for peripheral auditory research, and the coming decade promises to be most exciting indeed.

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Functional Mechanism of the Labyrinthine Epithelium: II. Author's Theory

Cited by 6 publications

References 0 publications

On the molecular filters in cochlea transduction

On the molecular filters in cochlea transduction

On the Molecular Filters in Cochlea Transduction

The peripheral auditory apparatus

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