Functional mechanisms of temperature regulation, adaptation and fever: Complementary system theoretical and experimental evidence

Werner, J.

doi:10.1016/0163-7258(88)90016-2

Cited by 16 publications

(5 citation statements)

References 78 publications

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“…How the multisensor, multieffector thermoregulatory system is functionally organized remains a subject of debate, although a consensus concept has been emerging (Romanovsky, 2007b). This concept is based on the idea that, similar to other physiological systems (Partridge, 1982), the thermoregulatory system functions as a federation of relatively independent effector loops (Satinoff, 1978), without a single controller and without a single set point or its equivalent (Werner, 1979(Werner, , 1988. Each thermoeffector loop includes a unique efferent neural pathway driving the corresponding effector response (Nagashima et al, 2000;Morrison et al, 2008).…”

Section: The Thermoregulatory Systemmentioning

confidence: 99%

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

et al. 2009

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Section: The Thermoregulatory Systemmentioning

confidence: 99%

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

et al. 2009

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“…Werner (1990) has reviewed the possible mechanisms involved in this response. There has been debate as to whether a pyrogen provokes a simple shift in a central thermoregulatory 'set point' or a change in sensitivity to the feedback information, that is a 'change in gain'.…”

Section: 'Hermoregulation and Fevermentioning

confidence: 99%

The effect of endotoxin‐induced fever on thermoregulation in the newborn rabbit.

Hull

Vinter

McIntyre

1993

The Journal of Physiology

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SUMMARY1. Metabolic responses of endotoxin-injected newborn rabbits were measured in a closed circuit calorimeter at a constant environmental temperature within their thermoneutral range. Oxygen consumption and colonic temperatures were then measured over a range of environmental temperatures from 21-0 to 40 0°C and the responses of endotoxin-injected rabbits compared with non-injected litter mates.2. To measure their preferred thermal environment, endotoxin-injected and noninjected litter mates were allowed to settle on a thermal gradient and their colonic temperatures measured.3. In a constant environmental temperature of 37°C, rises in oxygen consumption and colonic temperature following endotoxin injection were found to be biphasic.Oxygen consumption rose from 21 ml kg-' min-1 to a maximum 35 ml kg-1 minand colonic temperature rose from 39 0 to 39 8 'C.4. The maximal rate of oxygen consumption was the same in both injected and non-injected animals, 53 ml kg-1 min-', being provoked at the same environmental temperature of 24 'C. Minimal rates of oxygen consumption were also similar for the two groups but in the injected animals they were achieved at an environmental temperature of 39°C, 2 'C higher than for non-injected animals.5. We conclude that newborn rabbits challenged with a pyrogen have both behavioural and physiological responses. The thermogenic response is consistent with a change in sensitivity to feedback information rather than a simple shift in the central thermoregulatory set point. We find no evidence to support the view that in the febrile response a higher body temperature necessitates an increase in metabolic rate, the so-called Q1o effect.

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“…In spite of various challenges from the environment it is shown that human body core temperature is kept fairly constant 29 ) and that heat produced by the working muscles elevating the T c is independent of ambient temperature over a wide range 26 , 30 ) . On the other hand, skin temperatures are more influenced by the ambient temperature.…”

Section: Discussionmentioning

confidence: 99%

Work strain and thermophysiological responses in Norwegian fish farming — a field study

et al. 2022

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Fish farming is considered as a physical demanding occupation, including work operations with high workloads and awkward work positions for prolonged periods of time.Combined with potential challenging environmental conditions, these factors may negatively affect work performance, comfort and health. This study aimed to explore work strain and thermophysiological responses in Norwegian fish farming. Fourteen workers (age 35 ± 15 yrs) from four fish farms participated in the field studies, and measurements of heart rate (HR), core-and skin temperatures were registered continuously during a work shift.Questions about subjective thermal sensation and comfort were answered. This study has shown that workers at fish farms are periodically exposed to high or low levels of work strain, where the high workloads are manifested as increased core temperature and HR when working. The results are expected to give a better understanding of work strain and environmental challenges during fish farm operations.

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Functional mechanisms of temperature regulation, adaptation and fever: Complementary system theoretical and experimental evidence

Cited by 16 publications

References 78 publications

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

The effect of endotoxin‐induced fever on thermoregulation in the newborn rabbit.

Work strain and thermophysiological responses in Norwegian fish farming — a field study

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