Functional miR143/145 Cluster Variants and Haplotypes Are Associated with Chronic Kidney Disease: a Preliminary Case-Control Study and Computational Analyses

Sargazi, Saman; Nia, Milad Heidari; Sargazi, Fariba Mirani; Sheervalilou, Roghayeh; Bahrami, Sara; Mirinejad, Shekoufeh; Alidadi, Ali

doi:10.1007/s12010-021-03489-w

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…Several studies have explored the association between this polymorphism and the risk of human diseases. The frequencies of rs353292 TT/CT genotype were found to be significantly higher in patients with colorectal cancer and chronic kidney disease ( 27 , 28 ). However, the rs353292 polymorphism was not related to the risk of papillary thyroid carcinoma and conotruncal heart defects ( 18 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

et al. 2023

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ObjectiveTo evaluate the effects of two genetic variants in the promoter of the miR-143/145 cluster on the risk of epithelial ovarian cancer (EOC) and the prognosis of EOC patients.Study designGenotypes were determined by the polymerase chain reaction and ligase detection reaction method in 563 EOC patients and 576 healthy women. The expression of miR-143 and miR-145 were detected by quantitative real-time polymerase chain reaction (qRT–PCR) in fifty-two EOC tissues.ResultsThe rs4705342 CC genotype frequencies in EOC patients were higher than those in the controls (P = 0.014). Furthermore, the CC genotype of rs4705342 was associated with an advanced FIGO stage of EOC patients (P = 0.046). Patients with the rs4705342 CC genotype had shorter progression-free survival (PFS) and overall survival (OS) times than those carrying the TT genotype in multivariable analysis adjusting for clinical variables (HR = 1.30, 95% CI = 1.04-1.62, P = 0.020; HR = 1.33, 95% CI = 1.05-1.70, P = 0.020). In addition, the miR-145 levels were lower in EOC tissues with the rs4705342 CC genotype than in those with the TT genotype (P = 0.005).ConclusionThe CC genotype of rs4705342 was related to an increased risk of EOC and poor prognosis of EOC patients, and rs4705342 may serve as a molecular marker for predicting the development of EOC and the clinical outcome of EOC patients.

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Section: Discussionmentioning

confidence: 99%

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

et al. 2023

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“…The relationship between this genetic variant and disease risk has been investigated extensively, but the results are controversial. The TT/CT genotypes of rs353292 were found to be associated with a higher risk of chronic kidney disease and colorectal cancer (15,16). However, there was no significant correlation between the rs353292 polymorphism and susceptibility to papillary thyroid carcinoma and conotruncal heart defects (25,26).…”

Section: Discussionmentioning

confidence: 99%

“…Among them, rs4705342 and rs353292 are two potential functional polymorphisms that might influence the expression level of miR-143 (13,14). Previous studies have shown that these two polymorphisms are associated with the risk of chronic kidney disease, ischaemic stroke and colorectal cancer (15)(16)(17). However, little is known regarding the contribution of miR-143 genetic variants to T2DM development.…”

Section: Introductionmentioning

confidence: 99%

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Kong

Duan²,

Wang³

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.Study DesignThis case–control study involved 326 patients with T2DM and 342 healthy controls. Two genetic variants (rs4705342 and rs353292) of miR-143 were genotyped by the polymerase chain reaction/ligase detection reaction (PCR-LDR) method. The levels of miR-143 in the serum from 52 T2DM patients and 55 healthy subjects were investigated by quantitative real-time PCR (qRT–PCR).ResultsThe CC genotype frequency of rs4705342 was significantly higher in the T2DM patients than in the healthy controls (P = 0.012). After adjusting for sex, age, and body mass index, the rs4705342 CC genotype was also related to a significantly increased risk of T2DM compared with the TT genotype (adjusted OR: 1.87; 95% CI = 1.09-3.19; P = 0.022). Stratified analyses demonstrated that T2DM patients with the rs4705342 CC genotype had significantly higher levels of low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), and glycated haemoglobin (HbA1C) than those carrying the rs4705342 TT genotype. The qRT–PCR results showed that the expression levels of miR-143 were significantly higher in the serum of cases than in the serum of controls (P < 0.001). Furthermore, the levels of miR-143 were significantly higher in the serum of T2DM patients carrying the rs4705342 CC genotype than in those carrying the TC and TT genotypes of rs4705342 (P = 0.005 and 0.003, respectively).ConclusionThe CC genotype of rs4705342 might be a risk factor for developing T2DM by increasing the expression of miRNA-143 in the northern Chinese Han population.

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“…15 Other gene polymorphisms have also been recognized as predisposing risk factors and therapeutic targets for DM with or without kidney diseases. These include sirtuin 1 (SIRT1) rs12778366 and rs3758391, 16 β1-Adrenegic receptor (ADRB-1) rs1801253C/G, 17 NR1H2 gene encoding LXRβ (28,514,894 and rs2303044), 18 miR143/145 cluster, 19 and miR29a (rs157907A/G). 20 Insufficient cellular antioxidative defence caused by single nucleotide polymorphisms (SNPs) in these antioxidant enzymes may be involved in DN-associated T2D processes.…”

Section: Introductionmentioning

confidence: 99%

“… 15 Other gene polymorphisms have also been recognized as predisposing risk factors and therapeutic targets for DM with or without kidney diseases. These include sirtuin 1 ( SIRT1 ) rs12778366 and rs3758391, 16 β1‐Adrenegic receptor ( ADRB‐1 ) rs1801253C/G, 17 NR1H2 gene encoding LXRβ (28,514,894 and rs2303044), 18 miR143/145 cluster, 19 and miR29a (rs157907A/G). 20 …”

Section: Introductionmentioning

confidence: 99%

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

Sultan,

Alharbi,

Alrayes

et al. 2023

Endocrino Diabet & Metabol

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IntroductionOne of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end‐stage renal disease. Oxidative stress is implicated in DN pathogenesis, and genetic variations in antioxidant enzymes such as superoxide dismutase 2 (SOD2) and catalase (CAT) may contribute to the susceptibility. This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population.MethodsThis case–control study included 150 participants, comprising 50 patients with T2D without DN (group 1), 50 patients with T2D with DN (group 2), and 50 healthy participants (group 3). The samples were genotyped using real‐time PCR for SOD2 rs4880 and CAT rs769217 SNPs. Sanger sequencing was used for validation. Statistical analyses were performed to explore associations between these SNPs and T2D with or without DN.ResultsNo significant difference was observed in CAT rs769217 expression between the groups. However, a significant difference was observed in SOD2 rs4880 expression between the healthy controls and patients with T2D with DN (p = .028). Furthermore, SOD2 rs4880 was associated with approximately threefold increased risk of DN in patients with T2D compared to that in healthy participants (odds ratio [OR] = 2.99 [1.31–6.83]). Validation through Sanger sequencing further confirmed these findings.ConclusionsThe findings of this study provide evidence that SOD2 rs4880 SNP may contribute to inadequate defence by the antioxidant enzyme, SOD2, against DM‐induced oxidative stress and thus cause DN in Saudi patients with T2D. Therefore, SOD2 rs4880 may serve as a predictive marker to prevent the development and progression of DN in patients with T2D.

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Functional miR143/145 Cluster Variants and Haplotypes Are Associated with Chronic Kidney Disease: a Preliminary Case-Control Study and Computational Analyses

Cited by 9 publications

References 51 publications

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

The polymorphism rs4705342 in the promoter of miR-143/145 is related to the risk of epithelial ovarian cancer and patient prognosis

A functional polymorphism of microRNA-143 is associated with the risk of type 2 diabetes mellitus in the northern Chinese Han population

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

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