Functional mosaic organization of neuroligins in neuronal circuits

Qin, Liqiang; Guo, Sile; Ying, Han; Wang, Xiankun; Zhang, Bo

doi:10.1007/s00018-020-03478-y

Cited by 5 publications

(3 citation statements)

References 115 publications

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“…NLGN4X is a human specific gene for neuroligin production. Neuroligins, a family of cell adhesion molecules, are essential for synapse specification and maturation [ 17 ]. The product of TENM4 is a member of teneurin family.…”

Section: Discussionmentioning

confidence: 99%

Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma

et al. 2022

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Esophageal cancer has a poor prognosis due to its aggressiveness and low survival rate. In Ease Asia, esophageal squamous cell carcinoma (ESCC) outnumbers esophageal adenocarcinoma (EAC). The ESCC patients still have high mortality despite modern surgical resection and neoadjuvant treatment. Determining patient and outcome prognostic factors is critical in ESCC treatment. In esophageal cancer, early growth response-1 (Egr-1) is a tumor suppressor gene, but the mechanism and associated genes are unknown. The study utilizes RNA interference method, the platform of Next Generation Sequencing (NGS) and bioinformatics analysis to investigate the influences after the Egr-1 gene slicing on the ESCC cells. The heat maps of differentially expressed mRNA and microRNAs were analyzed using the algorithm, Burrows-Wheller Aligner. The study showed that the expression of 51 mRNA and 26 microRNAs have significant changes in ESCC cells after Egr-1 knockdown. The KEGG enrichment analysis linked Egr-1-regulated genes and microRNAs. Egr-1 interactions with these genes and microRNAs may be important in tumor progression. In conclusions, this study provided the transcriptome patterns and relating pathway analysis for Egr-1 knockdown in ESCC cells. The mRNA and microRNAs altered by Egr-1 gene silencing might provide key information in the treatment of ESCC.

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Section: Discussionmentioning

confidence: 99%

Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma

et al. 2022

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“…Full-length Nlgs are composed of an N-terminal domain, an extracellular globular cholinesterase-like domain, a highly O-glycosylated stalk domain, a single-pass transmembrane helical domain, and a short C-terminal cytoplasmic tail terminating in sites for PDZ domain-binding [ 15 ] ( Figure 1 ). The extracellular acetylcholinesterase-like domain of Nlgs enables them to interact with presynaptic Nrxs in an activity-dependent fashion, while the C-terminal domain of Nlgs can bind to the PDZ domains of postsynaptic scaffold proteins, including PSD-95 and gephyrin, which are involved in the anchoring of functional surface receptors and signaling proteins [ 16 ]. The differences in the postsynaptic scaffold proteins with which Nlgs interact suggest that different members of this family may play distinct roles in the context of synaptic function.…”

Section: The Structural Characteristics Of Neurexins and Neuroliginsmentioning

confidence: 99%

Modulation of Trans-Synaptic Neurexin–Neuroligin Interaction in Pathological Pain

Guo

Guan

et al. 2022

Cells

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Synapses serve as the interface for the transmission of information between neurons in the central nervous system. The structural and functional characteristics of synapses are highly dynamic, exhibiting extensive plasticity that is shaped by neural activity and regulated primarily by trans-synaptic cell-adhesion molecules (CAMs). Prototypical trans-synaptic CAMs, such as neurexins (Nrxs) and neuroligins (Nlgs), directly regulate the assembly of presynaptic and postsynaptic molecules, including synaptic vesicles, active zone proteins, and receptors. Therefore, the trans-synaptic adhesion mechanisms mediated by Nrx–Nlg interaction can contribute to a range of synaptopathies in the context of pathological pain and other neurological disorders. The present review provides an overview of the current understanding of the roles of Nrx–Nlg interaction in the regulation of trans-synaptic connections, with a specific focus on Nrx and Nlg structures, the dynamic shaping of synaptic function, and the dysregulation of Nrx–Nlg in pathological pain. Additionally, we discuss a range of proteins capable of modulating Nrx–Nlg interactions at the synaptic cleft, with the objective of providing a foundation to guide the future development of novel therapeutic agents for managing pathological pain.

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“…Prominent among synaptic cell-adhesion molecules that are expressed by astrocytes are neuroligins, a family of postsynaptic adhesion molecules that bind to presynaptic neurexins, presynaptic LAR-type receptor tyrosine phosphatases, and postsynaptic MDGA proteins (Liu et al, 2022;Liu et al, 2023;Connor et al, 2019;Qin et al, 2020;Südhof 2008;Bemben et al, 2015;Yoshida et al, 2021) (see below, Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture

Golf

Trotter

Nakahara

et al. 2023

Preprint

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Astrocytes exert multifarious roles in the formation, regulation, and function of synapses in brain, but the mechanisms involved remain unclear. Interestingly, astrocytes abundantly express neuroligins, postsynaptic adhesion molecules that bind to presynaptic neurexins. A pioneering recent study reported that loss-of-function of neuroligins in astrocytes impairs excitatory synapse formation and astrocyte morphogenesis. This study suggested a crucial function for astrocytic neuroligins but was puzzling given that constitutive neuroligin deletions do not decrease excitatory synapse numbers. Thus, we here examined the function of astrocytic neuroligins using a rigorous conditional genetic deletion of the major neuroligins (Nlgn1-3) in astrocytes. Our results show that early postnatal deletion of neuroligins from astrocytes has no effect on cortical or hippocampal synapses and does not alter the cytoarchitecture of astrocytes. Thus, astrocytic neuroligins are unlikely to shape synapse formation or astrocyte development but may have other important functions in astrocytes.

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Functional mosaic organization of neuroligins in neuronal circuits

Cited by 5 publications

References 115 publications

Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma

Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma

Modulation of Trans-Synaptic Neurexin–Neuroligin Interaction in Pathological Pain

Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture

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