Functional MR Imaging of the Cervical Spinal cord by Use of 20Hz Functional Electrical Stimulation to Median Nerve

Xie, Chu-hai; Kong, Kangmei; Guan, Jitian; Chen, Ye-xi; Wu, Renhua

doi:10.1109/iembs.2007.4353059

Cited by 10 publications

(33 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BOLD-based imaging methods have gained an important role in such studies, though a second source of functional contrast, signal enhancement by extravascular water protons, has been also applied by several groups (Stroman et al 2002;Stroman 2005;Xie et al 2007). The present study was focused on BOLD fMRI since it has been widely used in brain fMRI studies such that the underlying mechanism of this contrast is better understood.…”

Section: Discussionmentioning

confidence: 98%

Resting state networks in human cervical spinal cord observed with fMRI

Wei

Gao

et al. 2009

Eur J Appl Physiol

View full text Add to dashboard Cite

It has been reported that spontaneous fluctuations of blood oxygen level dependent (BOLD) signals can be detected in human brain and constitute resting state networks. It has not been reported whether resting state networks also exist in human spinal cord. In the present study, we investigate spontaneous BOLD signal changes in human cervical spinal cord during resting state. fMRI data were analyzed with independent component analysis and SPM software package. Acceptable reproducibility of spatial maps of BOLD signal changes was found across sessions, with the highest correlation values ranging from 0.18 to 0.44. The dominant frequency of signal changes from independent components with the highest correlation values was approximately the frequency range of the respiratory circle. Activities of spinal motor neurons innervating the scalenes were considered as a major factor in the production of BOLD signal fluctuations were observed in this study. Our findings suggest that BOLD fMRI can be applied to study the features of low-frequency rhythmic activities and corresponding mechanisms in the spinal cord during resting state.

show abstract

Section: Discussionmentioning

confidence: 98%

Resting state networks in human cervical spinal cord observed with fMRI

Wei

Gao

et al. 2009

Eur J Appl Physiol

View full text Add to dashboard Cite

show abstract

“…Again in the rat, functional plastic changes at the spinal cord level following experimental spinal cord injury have been revealed by a recent fMRI study (20). After these piloting studies on the motor system, the somato-sensory system is also now successfully investigated in humans (44,91). These studies convincingly demonstrate that fMRI can be used to explore the function of the spinal cord in pain processing.…”

Section: Are "Classical" Pain-processing Regions Modulated When the Pmentioning

confidence: 88%

“…Spinal cord fMRI in the rat has been shown to anatomically distinguish signal changes related to motor, pain, and tactile activity (40,91). The study by Lilja et al (40) also showed a pharmacological modulation of the spinal cord signal in response to morphine, which could be reversed by naloxone.…”

Section: Are "Classical" Pain-processing Regions Modulated When the Pmentioning

confidence: 93%

Imaging CNS Modulation of Pain in Humans

2008

View full text Add to dashboard Cite

Pain is a highly complex and subjective experience that is not linearly related to the nociceptive input. What is clear from anecdotal reports over the centuries and more recently from animal and human experimentation is that nociceptive information processing and consequent pain perception is subject to significant pro- and anti-nociceptive modulations. These modulations can be initiated reflexively or by contextual manipulations of the pain experience including cognitive and emotional factors. This provides a necessary survival function since it allows the pain experience to be altered according to the situation rather than having pain always dominate. The so-called descending pain modulatory network involving predominantly medial and frontal cortical areas, in combination with specific subcortical and brain stem nuclei appears to be one key system for the endogenous modulation of pain. Furthermore, recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states. Research on the involved circuitry and implemented mechanisms is a major focus of contemporary neuroscientific research in the field of pain and should provide new insights to prevent and treat chronic pain states.

show abstract

“…9 Four authors noted that the expected location of functional activation of any particular dermatome or myotome was roughly one VB level above the intervertebral foramen that contains the nerve root supplying that dermatome or myotome. 24,28,33,34 Inducing Neural Activity in the Spinal Cord: Choice of a Stimulation Paradigm…”

Section: Localizing the Fmri Signal To An Anatomical Region Of The Spmentioning

confidence: 99%

A systematic review of spinal fMRI research: outlining the elements of experimental design

Cadotte

Stroman

Mikulis

et al. 2012

SPI

View full text Add to dashboard Cite

Object Since the first published report of spinal functional MRI (fMRI) in humans in 1996, this body of literature has grown substantially. In the present article, the authors systematically review all spinal fMRI studies conducted in healthy individuals with a focus on the different motor and sensory paradigms used and the results acquired. Methods The authors conducted a systematic search of MEDLINE for literature published from 1990 through November 2011 reporting on stimulation paradigms used to assess spinal fMRI scans in healthy individuals. Results They identified 19 peer-reviewed studies from 1996 to the present in which a combination of different spinal fMRI methods were used to investigate the spinal cord in healthy individuals. Eight of the studies used a motor stimulation paradigm, 10 used a sensory stimulation paradigm, and 1 compared motor and sensory stimulation paradigms. Conclusions Despite differences in the results of various studies, even when similar stimulation paradigms were used, this body of literature underscores that spinal fMRI signals can be obtained from the human spinal cord. The authors intend this review to serve as an introduction to spinal fMRI research and what it may offer the field of spinal cord injury research.

show abstract

Functional MR Imaging of the Cervical Spinal cord by Use of 20Hz Functional Electrical Stimulation to Median Nerve

Cited by 10 publications

References 25 publications

Resting state networks in human cervical spinal cord observed with fMRI

Resting state networks in human cervical spinal cord observed with fMRI

Imaging CNS Modulation of Pain in Humans

A systematic review of spinal fMRI research: outlining the elements of experimental design

Contact Info

Product

Resources

About