Functional MRI in NPSLE patients reveals increased parietal and frontal brain activation during a working memory task compared with controls

Fitzgibbon, Bernadette M.; Fairhall, Scott L.; Kirk, Ian J.; Kalev‐Zylinska, Maggie L.; Pui, Karen; Dalbeth, Nicola; Keelan, Stephen; Robinson, Elizabeth; During, Matthew J.; McQueen, Fiona

doi:10.1093/rheumatology/kem287

Cited by 47 publications

(51 citation statements)

References 15 publications

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“…Two fMRI studies previously reported increased regional activation patterns in patients with NPSLE in response to memory and simple motor tasks compared with healthy controls (25,26). Another fMRI study of 10 pediatric SLE patients, not selected for NPSLE, also reported increased cortical activation patterns compared with healthy controls in response to memory, attention and The coordinates and cluster sizes of the regions with significant differences in BOLD signal intensity between the ST and LT subjects during performance of the modified Sternberg task (two shapes retention phase) are listed.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, fMRI provides an objective measure of functional neural networks solicited by specific probes. Three previous fMRI studies in SLE patients compared with healthy controls have all demonstrated abnormally increased regional brain activation patterns in areas targeted by specific tasks (24)(25)(26). We asked whether these abnormalities also correlate with disease duration.…”

Section: Differences In Regional Brain Activation Patterns Assessed Bmentioning

confidence: 95%

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Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration

Mackay

Bussa

Aranow

et al. 2011

Mol Med

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The mediators of tissue damage in systemic lupus erythematosus (SLE) such as antibodies, cytokines and activated immune cells have direct access to most organs in the body but must penetrate the blood-brain barrier (BBB) to gain access to brain tissue. We hypothesized that compromise of the BBB occurs episodically such that the brain will acquire tissue damage slowly and not at the same rate as other organs. On the basis of these assumptions, we wished to determine if duration of disease correlated with brain injury, as measured with functional magnetic resonance imaging (fMRI), and if this was independent of degree of tissue damage in other organs. We investigated differences in brain activation patterns using fMRI in 13 SLE patients stratified by disease duration of ≤2 years (short-term [ST]) or ≥10 years (long-term [LT]). Two fMRI paradigms were selected to measure working memory and emotional response (fearful faces task). Performance in the working memory task was significantly better in the ST group for one and two shape recall; however, both groups did poorly with three shape recall. Imaging studies demonstrated significantly increased cortical activation in the ST group in regions associated with cognition during the two shape retention phase of the working memory task (P < 0.001) and increased amygdala (P < 0.05) and superior parietal (P < 0.01) activation in response to the fearful faces paradigm. In conclusion, analysis of activation patterns stratified by performance accuracy, differences in comorbid disease, corticosteroid doses or disease activity suggests that these observed differences are attributable to SLE effects on the central nervous system exclusive of vascular disease or other confounding influences. Our hypothesis is further supported by the lack of correlation between regional brain abnormalities on fMRI and the Systemic Lupus International Collaborating Clinics (SLICC) damage index.

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Section: Discussionmentioning

confidence: 99%

Section: Differences In Regional Brain Activation Patterns Assessed Bmentioning

confidence: 95%

Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration

Mackay

Bussa

Aranow

et al. 2011

Mol Med

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“…Evidence supports the notion that increased effort of a task results in enhanced activation on fMRI. [61][62][63] Fitzgibbon et al 64 also examined working memory, executive function and attention in adult SLE patients and also found greater frontoparietal activation in adult SLE patients than healthy controls, implying also that the same cognitive operations required more cortical activity in SLE patients.…”

Section: Association Of Regional Brain Activity and Domains Of Neurocmentioning

confidence: 99%

Pathogenesis of neurocognitive and neuropsychiatric manifestations in childhood-onset lupus: an overview

2014

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This review explores current understanding of neuropsychiatric systemic lupus erythematosus (NPSLE) of childhood onset, in particular neurocognitive impairment. As yet, fewer studies have focused on childhood onset NPSLE compared to adult onset NPSLE and diagnosis still involves the 1999 American College of Rheumatology case definitions of neuropsychiatric syndromes, which were developed for adults. Although a validated core set of neuropsychometric tests exist for childhood onset NPSLE, these still have limitations and possible biomarkers and newer neuroimaging modalities remain mostly experimental. Important differences exist between childhood and adult onset SLE and specifically with NPSLE, outlined in this review. Normal adolescent brain development also involves significant differences from adults, particularly in executive function and social cognition. These issues may impact on the pathogenesis of NPSLE during this vulnerable period and also influence their management options.

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“…En pacientes con LESNP se encontró una baja perfusión en el lóbulo frontal al utilizar SPECT y la intensidad de esta lesión se correlacionó con mayor déficit cognitivo 67 . En lo que respecta a la RNM funcional se ha observado una mayor activación frontoparietal en tareas de memoria, posiblemente por reclutar más vías neuronales por defecto de las originales 68 , y alteraciones en la sustancia blanca del cuerpo calloso en pacientes LESNP 69,70 o un adelgazamiento de la sustancia gris cortical y subcortical 71,72 . No se encontró asociación en la disfunción endotelial cerebral cuantificada a través de Eco Doppler 22,73 , ni en histograma de transferencia magnética 74 .…”

Section: Imágenes Diagnósticasunclassified

Actualización en lupus neuro-psiquiátrico con énfasis en déficit cognitivo

et al. 2012

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Functional MRI in NPSLE patients reveals increased parietal and frontal brain activation during a working memory task compared with controls

Abstract: NPSLE patients showed greater frontoparietal activation than the other groups during the memory task, suggesting a greater need to recruit extra cortical pathways, possibly to supplement impaired function of standard pathways.

Cited by 47 publications

References 15 publications

Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration

Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration

Pathogenesis of neurocognitive and neuropsychiatric manifestations in childhood-onset lupus: an overview

Actualización en lupus neuro-psiquiátrico con énfasis en déficit cognitivo

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