Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery—A Critical Review

Li, Zhen; Shunqi, Mei; Dong, Yajie; She, Fenghua; Li, Yongzhen; Li, Puwang; Kong, Lingxue

doi:10.3390/pharmaceutics12060522

Cited by 30 publications

(22 citation statements)

References 141 publications

(160 reference statements)

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“…Additionally, controlled release is essential, otherwise excessive dosages of antibiotics will confer cytotoxic effects on osteogenic cell populations (Feng et al, 2010;Park, 2011). Use of nanocoatings or nanofiber delivery mechanisms (Han et al, 2017;Li Z. et al, 2020) to convey antimicrobial properties should be further explored (Kumar et al, 2020). Scaffold modifications with anti-fouling, zwitterionic polymer coatings (Chen et al, 2019) and antimicrobial peptides (Liang et al, 2021) represent promising alternative strategies to discourage biofilm formation or microbial infections.…”

Section: Scaffold Functionalization With Bioactive Moleculesmentioning

confidence: 99%

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Latimer

Maekawa

Yao

et al. 2021

Front. Bioeng. Biotechnol.

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Additive manufacturing (AM) is the automated production of three-dimensional (3D) structures through successive layer-by-layer deposition of materials directed by computer-aided-design (CAD) software. While current clinical procedures that aim to reconstruct hard and soft tissue defects resulting from periodontal disease, congenital or acquired pathology, and maxillofacial trauma often utilize mass-produced biomaterials created for a variety of surgical indications, AM represents a paradigm shift in manufacturing at the individual patient level. Computer-aided systems employ algorithms to design customized, image-based scaffolds with high external shape complexity and spatial patterning of internal architecture guided by topology optimization. 3D bioprinting and surface modification techniques further enhance scaffold functionalization and osteogenic potential through the incorporation of viable cells, bioactive molecules, biomimetic materials and vectors for transgene expression within the layered architecture. These computational design features enable fabrication of tissue engineering constructs with highly tailored mechanical, structural, and biochemical properties for bone. This review examines key properties of scaffold design, bioresorbable bone scaffolds produced by AM processes, and clinical applications of these regenerative technologies. AM is transforming the field of personalized dental medicine and has great potential to improve regenerative outcomes in patient care.

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Section: Scaffold Functionalization With Bioactive Moleculesmentioning

confidence: 99%

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Latimer

Maekawa

Yao

et al. 2021

Front. Bioeng. Biotechnol.

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“…The variation in the electrospun setup to obtain the nanofiber for specific application leads to the design of different types of electrospinning. The primary incorporation of drugs into the polymer is the dispersion or dissolving of drugs in the solution polymer, and after that is the electrospinning approach [104,[108][109][110][111]. There are several electrospinning methods for incorporation of drugs for drug delivery applications including solution electrospinning, emulsion electrospinning, surface modification electrospinning, side by side electrospinning (janus), multi jet electrospinning, multiaxial electrospinning, coaxial electrospinning, and blending electrospinning as shown in Fig.…”

Section: Electrospinning As a Drug Incorporation Techniquementioning

confidence: 99%

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Zare

Ramakrishna

2020

Proceedings of the 1st International Electronic Conference on Pharmaceutics

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Electrospinning is a powerful and cost-effective method that applies a strong electric field and polymer solution to fabricate versatile nanofiber using a wide array of raw materials for different biological applications. Electrospun nanofibers have developed as potential materials for the manufacturing of nanocarriers for therapeutic platforms due to controllable surface decoration, large surface areas, complex pore structure, good surface functionalization with high biocompatibility. The prominence of this technique is the possibility of merging low soluble drugs loaded in the nanofibers to enhance drug release and bioavailability. Incorporation of metal nanomaterials with electrocatalytic and/or plasmonic features into electrospun polymer nanofiber enhances thermodynamic and mechanical properties to obtain synergetic function and properties. This review comprehensively discusses an overview of theory of electrospinning, progress and concerns, and challenges currently face in fabricating efficient and effective drug delivery systems. Additionally, the drug-loaded into electrospun nanocarriers for drug delivery applications and insights into future prospects were explained.

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“…Nanofiber sheets (NS) can be used in various biomedical applications such as drug carriers, wound healing, scaffolding for tissue engineering, etc. [ 10 , 11 ]. Over the past few years, the development of NS for biomedical applications has grown remarkably.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Electrospun Small Intestinal Submucosa/Poly(caprolactone-co-Lactide-co-glycolide) Nanofiber Sheet as a Potential Drug Carrier

et al. 2021

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In this work, we chose small intestine submucosa (SIS) as a drug carrier because SIS possesses good biocompatibility, non-immunogenic property and bio-resorbability, and performed electrospinning for preparation of nanofiber sheets (NS). For the preparation of drug-loaded electrospun SIS nanofiber sheets as a drug carrier, we used poly(ε-caprolactone-ran-l-lactide) (PCLA) copolymers to improve the electrospinning performance of SIS. The electrospinning of SIS and PCLA provided the electrospun SIS/PCLA (S/P)-nanofiber sheet (S/P-NS) with adjustable thickness and areas. The electrospun S/P-NS showed different porosities, pore sizes, diameters and tensile strengths depending on the ratios between SIS and PCLA. The electrospun S/P-NS was used as a drug carrier of the dexamethasone (Dex) and silver sulfadiazine (AgS) drug related to anti-inflammation. Dex-loaded S/P-NS and AgS-loaded S/P-NS was successfully fabricated by the electrospinning. In the in vitro and in vivo release, we successfully confirmed the possibility for the sustained release of Dex and AgS from the Dex-S/P-NS and AgS-S/P-NS for three weeks. In addition, the sustained Dex and AgS release suppressed the macrophage infiltration. Collectively, we achieved feasible development of SIS nanofiber sheets for a sustained Dex and AgS delivery system.

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Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery—A Critical Review

Cited by 30 publications

References 141 publications

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Current Progress of Electrospun Nanocarriers for Drug Delivery Applications

Preparation of Electrospun Small Intestinal Submucosa/Poly(caprolactone-co-Lactide-co-glycolide) Nanofiber Sheet as a Potential Drug Carrier

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