Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study

Otti, Alexander; Guendel, Harald; Henningsen, Peter; Zimmer, Claus; Wohlschläeger, Afra; Noll‐Hussong, Michael

doi:10.1503/jpn.110187

Cited by 44 publications

(29 citation statements)

References 60 publications

(89 reference statements)

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“…Our results are similar to some other studies that have demonstrated alterations of default mode network connectivity in patients with chronic pain disorders [6; 7; 56; 58; 81]. Similar to our study, increased connectivity within the default mode network has been observed in fibromyalgia patients but the activity was mainly observed in regions different to those found in this study (such as in the anterior, middle, and posterior insula) [56].…”

Section: Discussionsupporting

confidence: 92%

Disease-related differences in resting-state networks

Gupta

Rapkin

Gill

et al. 2015

Pain

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Localized provoked vulvodynia (LPVD) affects approximately 16% of the female population, but biological mechanisms underlying symptoms remain unknown. Like in other, often comorbid chronic pain disorders, altered sensory processing and modulation of pain, including central sensitization, dysregulation of endogenous pain modulatory systems, and attentional enhancement of pain perception have been implicated. The aim of this study was to test whether regions of interest showing differences in LPVD compared to healthy controls (HCs) in structural and evoked-pain neuroimaging studies, also show alterations in during rest compared to HCs and a chronic pain control group (irritable bowel syndrome, IBS). Functional magnetic resonance imaging was performed during resting state in 87 age-matched premenopausal females (29 LPVD, 29 HCs, 29 IBS). Group independent component analysis and general linear models were applied to investigate group differences in the intrinsic connectivity of regions comprising sensorimotor, salience, and default mode resting state networks. LPVD subjects showed substantial alterations in the intrinsic connectivity of these networks compared to HCs and IBS. The intrinsic connectivity of many of the regions showing group differences during rest were moderately associated with clinical symptom reports in LPVD. Findings were robust to controlling for affect and medication usage. The current findings indicate LPVD subjects have alterations in the intrinsic connectivity of regions comprising the sensorimotor, salience, and default mode networks. Although shared brain mechanisms between different chronic pain disorders have been postulated, the current findings suggest some alterations in functional connectivity may show disease specificity.

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Section: Discussionsupporting

confidence: 92%

Disease-related differences in resting-state networks

Gupta

Rapkin

Gill

et al. 2015

Pain

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“…Moreover, alterations of the time lags were found in the pairs of RSNs. Otti et al found lost connectivities or combinations in the patients [ 49 ] with somatoform pain disorder, indicating impairments on the system level. On the contrary, Luo et al found no significant difference of interaction in two RSNs between TLE and HC [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Altered Intrinsic Connectivity Networks in Frontal Lobe Epilepsy: A Resting-State fMRI Study

Cao

Qian

et al. 2014

Computational and Mathematical Methods in Medicine

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Examining the resting-state networks (RSNs) may help us to understand the neural mechanism of the frontal lobe epilepsy (FLE). Resting-state functional MRI (fMRI) data were acquired from 46 patients with FLE (study group) and 46 age- and gender-matched healthy subjects (control group). The independent component analysis (ICA) method was used to identify RSNs from each group. Compared with the healthy subjects, decreased functional connectivity was observed in all the networks; however, in some areas of RSNs, functional connectivity was increased in patients with FLE. The duration of epilepsy and the seizure frequency were used to analyze correlation with the regions of interest (ROIs) in the nine RSNs to determine their influence on FLE. The functional network connectivity (FNC) was used to study the impact on the disturbance and reorganization of FLE. The results of this study may offer new insight into the neuropathophysiological mechanisms of FLE.

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“…Participants gave written informed consent in accordance with the guidelines of the Declaration of Helsinki. Most of the subjects were participants (“control group”) of other neuroimaging studies performed by our research group [ 15 – 19 ]. This study was approved by the Ethics Committee of the Rechts der Isar Hospital, Technical University of Munich.…”

Section: Methodsmentioning

confidence: 99%

Is the Medial Prefrontal Cortex Necessary for Theory of Mind?

2015

Self Cite

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BackgroundSuccessful social interaction relies on the ability to attribute mental states to other people. Previous functional neuroimaging studies have shown that this process, described as Theory of Mind (ToM) or mentalization, is reliably associated with activation of the medial prefrontal cortex (mPFC). However, this study presents a novel and surprising finding that provides new insight into the role of the mPFC in mentalization tasks.Methodology/Principal FindingsTwenty healthy individuals were recruited from a wide range of ages and social backgrounds. Participants underwent functional magnetic resonance imaging (fMRI) while viewing a well-established ToM visual paradigm involving moving triangles. Functional MRI data were analyzed using a classical general linear model. No activation was detected in the medial prefrontal cortex (mPFC) during movement patterns that typically elicit ToM. However, increased activity was observed in the right middle occipital gyrus, right temporoparietal junction (TPJ), left middle occipital gyrus and right inferior frontal gyrus. No correlation was found between participants’ age and BOLD response.Conclusions/SignificanceIn contrast with previous neuroimaging research, our findings support the notion that mPFC function is not critical for reasoning about the mental states of others; furthermore, our data indicate that the right TPJ and right inferior frontal gyrus are able to perform mentalization without any contributions from the mPFC.

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Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study

Cited by 44 publications

References 60 publications

Disease-related differences in resting-state networks

Disease-related differences in resting-state networks

Altered Intrinsic Connectivity Networks in Frontal Lobe Epilepsy: A Resting-State fMRI Study

Is the Medial Prefrontal Cortex Necessary for Theory of Mind?

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