Functional neuroanatomy of the auditory cortex studied with [2-14C]deoxyglucose

Hungerbühler, Jean Pierre; Saunders, James C.; Greenberg, Joel; Reivich, Martin

doi:10.1016/0014-4886(81)90074-1

Cited by 39 publications

(2 citation statements)

References 15 publications

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“…Interestingly, these difficulties mirrored early investigations of ACX organization with 2-deoxyglucose [30, 31], which had been utilized to great effect in visual cortex [32,33]. …”

Section: Low Resolution Optical Imaging Reveals Tonotopic Ordermentioning

confidence: 99%

Local versus global scales of organization in auditory cortex

Kanold

Nelken

Polley

2014

Trends in Neurosciences

108

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Topographic organization is a hallmark of sensory cortical organization. Topography is robust at spatial scales ranging from hundreds of microns to centimeters, but can dissolve at the level of neighboring neurons or subcellular compartments within a neuron. This dichotomous spatial organization is especially pronounced in the mouse auditory cortex, where an orderly tonotopic map can arise from heterogeneous frequency tuning between local neurons. Here, we address a debate surrounding the robustness of tonotopic organization in the auditory cortex that has persisted in some form for over forty years. Drawing from various cortical areas, cortical layers, recording methodologies, and species, we describe how auditory cortical circuitry can simultaneously support a globally systematic, yet locally heterogeneous representation of this fundamental sound property.

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“…Interestingly, these difficulties mirrored early investigations of ACX organization with 2-deoxyglucose [30, 31], which had been utilized to great effect in visual cortex [32,33]. …”

Section: Low Resolution Optical Imaging Reveals Tonotopic Ordermentioning

confidence: 99%

Local versus global scales of organization in auditory cortex

Kanold

Nelken

Polley

2014

Trends in Neurosciences

108

View full text Add to dashboard Cite

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“…Previous attempts to reveal the tonotopic organization of auditory cortex with the 2DG method in the gerbil, rat and cat (Webster et al, 1978; Hungerbuhler et a l . , 1981;Ryan et al, 1982;Gonzalez-Lima and Scheich, 1986) yielded rather poor and hard to interpret labelling. In contrast, the bird telencephalic analogue of the auditory cortex, field L, showed distinct and quantifiable tonotopic labelling (Scheich et al, 1979;Muller and Scheich, 1985;Heil and Scheich, 1985, 1991, 1992a, which was successfully used as a frame of reference for labelling induced by complex auditory stimuli (Heil and Scheich, 1992b).…”

Section: Introductionmentioning

confidence: 99%

Functional Organization of Auditory Cortex in the Mongolian Gerbil (Meriones unguiculatus) II. Tonotopic 2‐Deoxyglucose

Scheich

Heil

Langner

1993

Eur J of Neuroscience

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The tonotopic organization of the auditory cortex in the Mongolian gerbil was mapped with 2-deoxyfluoro-D-glucose (2DG) using narrow-band frequency-modulated tones of different centre frequency (FM tones) and tones periodically alternating between two different frequencies (alternating tones) as stimuli. Continuous tone bursts of a constant frequency and repetition rate were used in initial experiments. Continuous tones produced 2DG patterns similar to those observed in animals that were not specifically stimulated. With tone bursts of constant frequency and repetition rate variable patterns were observed, some of which could be interpreted only in retrospect in the light of results obtained with FM tones and alternating tones. These stimuli, in contrast, produced differential metabolic responses which in conjunction with 2DG data from monaural animals and electrophysiological data made it possible to distinguish a primary auditory field AI with its dorsal region Ald, an anterior auditory field AAF, a ventral field V, a dorsoposterior field DP and a ventroposterior field VP, a dorsal field D, and in addition an anteroventral field AV. In the largest field (AI) and the smaller rostrally adjacent field AAF, frequency-specific dorsoventral bands of labelling (isofrequency contours) were mapped quantitatively. Bands shifted as a function of frequency relative to each other and to an independent spatial reference line in the lateral hippocampus. Spatial analysis of the single bands obtained with FM tones, and of the double bands obtained with alternating tones in both fields, revealed roughly mirror-imaged tonotopic maps of AI and AAF. In AI the progression from low to high frequencies was from caudal to rostral and in AAF the gradient was reversed, leading to a common high-frequency border of the two fields. In AI, the spatial resolution for frequencies below 16 kHz was in similar intervals per octave and higher for frequencies below 1 kHz. AI showed a somewhat higher spatial resolution for frequencies (at least below 1 kHz) as well as longer isofrequency contours than AAF. The 2-deoxyglucose patterns provided average tonotopic maps and topological data on various fields, as well as reliable landmarks in the gerbil's auditory cortex.

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Tonotopic organization in the central auditory pathway of the mongolian gerbil: A 2‐deoxyglucose study

Ryan

Woolf

Sharp

1982

J of Comparative Neurology

150

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The uptake of 2-deoxyglucose (2-DG) was employed to map functional activation of the central auditory pathway in the mongolian gerbil, during 85 dB SPL stimulation with pure tonal stimuli at frequencies of 0.75, 3.0, or 12.0 kHz. Pure tones produced foci of very high 2-DG uptake, when compared to adjacent tissue, in the cochlear nucleus, superior olivary complex, and inferior colliculus. Less distinct areas of elevated 2-DG uptake were seen in the dorsal and ventral nuclei of the lateral lemniscus, medial geniculate nucleus, and auditory cortex. Little or no change in the distribution of 2-DG uptake was noted in the nucleus of the trapezoid body. The location of discrete regions of relatively high 2-DG uptake varied systematically with stimulus frequency. The tonotopic organization demonstrated by 2-DG mapping agreed well with the results of previous electrophysiological studies for most structures. However, in the inferior colliculus, stimulus-evoked increases in 2-DG uptake were found to occur in a fixed pattern of three to four bands across the central nucleus, which did not correspond to any previously reported anatomical or physiological organization. Pure tonal stimuli activated discrete portions of this banding pattern. Also, a small area at the ventromedial edge of the colliculus was more broadly tuned than other regions of the nucleus. It is concluded that 2-DG uptake is well suited to the investigation of tonotopic organization. This technique reveals patterns of activation which have not been observed with other methodologies.

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Functional neuroanatomy of the auditory cortex studied with [2-14C]deoxyglucose

Cited by 39 publications

References 15 publications

Local versus global scales of organization in auditory cortex

Local versus global scales of organization in auditory cortex

Functional Organization of Auditory Cortex in the Mongolian Gerbil (Meriones unguiculatus) II. Tonotopic 2‐Deoxyglucose

Tonotopic organization in the central auditory pathway of the mongolian gerbil: A 2‐deoxyglucose study

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