Functional neuroimaging in specific phobia

Casale, Antonio Del; Ferracuti, Stefano; Rapinesi, Chiara; Serata, Daniele; Piccirilli, Massimo; Savoja, Valeria; Kotzalidis, Georgios D.; Manfredi, Giovanni; Angeletti, Gloria; Tatarelli, Roberto; Girardi, Paolo

doi:10.1016/j.pscychresns.2011.10.009

Cited by 82 publications

(72 citation statements)

References 80 publications

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“…SPs are common, with lifetime prevalence estimates of 10% (Del Casale et al, 2012). Despite the low proportion of phobia sufferers who seek treatment, specific phobia is among the most treatable of disorders.…”

Section: Spmentioning

confidence: 99%

The efficacy and effectiveness of psychological treatments for mood, anxiety, and related disorders.

Hunsley¹,

Elliott²,

Therrien³

2014

Canadian Psychology / Psychologie canadienne

101

106

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We provide a narrative review of the extensive evidence that supports the efficacy and effectiveness of psychological treatments, across the life span, for common mental health disorders. To this end, relying primarily on meta-analytic studies, we examine the effects of psychological treatments for depression, bipolar disorder, generalised anxiety disorder, social anxiety disorder, specific phobia, panic disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. Based upon data from hundreds of studies and thousands of participants, there is substantial evidence for both the efficacy and effectiveness of specific forms of psychological intervention for these disorders. Moreover, for most disorders, the clinical impact of specific forms of psychological treatment has been found to be at least equal to that of medication. Accordingly, the research evidence strongly supports the use of a number of specific psychological treatments, most of which are cognitive-behavioural treatments, as first-line interventions for these commonly occurring mental disorders among youth, adults, and older adults.

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Section: Spmentioning

confidence: 99%

The efficacy and effectiveness of psychological treatments for mood, anxiety, and related disorders.

Hunsley¹,

Elliott²,

Therrien³

2014

Canadian Psychology / Psychologie canadienne

101

106

View full text Add to dashboard Cite

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“…These data support the amygdala as part of a brain network subserving fear processing, which includes the anterior cingulate cortex, thalamus, insula, and visual association and motor cortices (Del Casale et al, 2012). The amygdala is believed to occupy a central role through receipt of sensory inputs which trigger emotional, autonomic, and motor responses through direct and indirect onward projections (LeDoux, 2000).…”

Section: Discussionmentioning

confidence: 56%

“…There is also the possibility of extraamygdalar involvement, in this instance extending in part to the entorhinal cortex. This area does possess connections with the amygdala (Paré, Dong, & Gaudreau, 1995) but is not considered to be key in specific phobia (Del Casale et al, 2012). Mr. A's anti-epileptic medication is unlikely to have played any role as despite its mood stabilizing properties, there is no evidence for carbamazepine efficacy in specific phobia (Choy, Fyer, & Lipsitz, 2007;Mula, Pini, & Cassano, 2007).…”

Section: Discussionmentioning

confidence: 99%

Abolition of lifelong specific phobia: a novel therapeutic consequence of left mesial temporal lobectomy

2014

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Numerous imaging studies have confirmed the amygdala as prominent within a neural network mediating specific phobia, including arachnophobia. We report the case of a patient in whom arachnophobia was abolished after left temporal mesial lobectomy, with unchanged fear responses to other stimuli. The phenomenon of abolition of specific phobia after amygdala removal has not, to our knowledge, been previously reported.

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“…Perseverative cognitions are also present in other emotional conditions notably obsessive compulsive disorder (OCD; Cavedini, Ferri, Scarone, & Bellodi, 1998) where early SPECT and PET neuroimaging studies neatly illustrated both the presence of neostriatal and orbitofrontal abnormalities in OCD patients (Busatto et al, 2000;Mcguire et al, 1994;Rauch et al, 1994) and the resolution of such abnormalities following effective pharmacological or psychological treatment (Baxter et al, 1992). Across anxiety conditions, the engagement of an arousal/salience network, with the signature of dorsal cingulate and insula activity, represents the most commonly observed response to provocative emotional stimuli (Caseras et al, 2013;Del Casale et al, 2012;Etkin & Wager, 2007). However, paradoxical responses to affective stimuli are frequently observed in anxiety patients and typically reflect heightened threat attributed to normally neutral 'control' stimuli in conjunction with ceiling effects for targetnegative emotive stimuli (Somerville, Kim, Johnstone, Alexander, & Whalen, 2004).…”

Section: Disorders Of Emotionmentioning

confidence: 99%