Functional neuroimaging with MEG: Normative language profiles

Papanicolaou, Andrew C.; Pazo-Álvarez, Paula; Castillo, Eduardo M.; Billingsley-Marshall, Rebecca; Breier, Joshua I.; Swank, Paul R.; Buchanan, Scott; McManis, Mark H.; Clear, T.; Passaro, Antony D.

doi:10.1016/j.neuroimage.2006.06.020

Cited by 61 publications

(54 citation statements)

References 38 publications

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“…The present data are consistent with the idea that early cognitive language processing is bilaterally distributed, whereas late processing is lateralized to the dominant hemisphere (Merrifield et al, 2007;Papanicolaou et al, 2006). These data point to the importance of the dynamics of cortical activation for accurate processing of auditory sublexical stimuli and are consistent with the recently proposed dual-stream model of auditory processing.…”

Section: Discussionsupporting

confidence: 92%

Objective phonological and subjective perceptual characteristics of syllables modulate spatiotemporal patterns of superior temporal gyrus activity

et al. 2008

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Natural consonant vowel syllables are reliably classified by most listeners as voiced or voiceless. However, our previous research (Liederman et al., 2005) suggests that among synthetic stimuli varying systematically in voice onset time (VOT), syllables that are classified reliably as voiceless are nonetheless perceived differently within and between listeners. This perceptual ambiguity was measured by variation in the accuracy of matching two identical stimuli presented in rapid succession. In the current experiment, we used magnetoencephalography (MEG) to examine the differential contribution of objective (i.e., VOT) and subjective (i.e., perceptual ambiguity) acoustic features on speech processing. Distributed source models estimated cortical activation within two regions of interest in the superior temporal gyrus (STG) and one in the inferior frontal gyrus. These regions were differentially modulated by VOT and perceptual ambiguity. Ambiguity strongly influenced lateralization of activation; however, the influence on lateralization was different in the anterior and middle/posterior portions of the STG. The influence of ambiguity on the relative amplitude of activity in the right and left anterior STG activity depended on VOT, whereas that of middle/posterior portions of the STG did not. These data support the idea that early cortical responses are bilaterally distributed whereas late processes are lateralized to the dominant hemisphere and support a "how/what" dualstream auditory model. This study helps to clarify the role of the anterior STG, especially in the right hemisphere, in syllable perception. Moreover, our results demonstrate that both objective phonological and subjective perceptual characteristics of syllables independently modulate spatiotemporal patterns of cortical activation.Please send all correspondence to:

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Section: Discussionsupporting

confidence: 92%

Objective phonological and subjective perceptual characteristics of syllables modulate spatiotemporal patterns of superior temporal gyrus activity

et al. 2008

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“…The use of MEG to localize receptive language areas to Wernicke's area has been well documented [10] and validated [11][12][13][14]. The development of MEG protocols to study expressive language has been more challenging for a number of reasons, the primary one being the computational limitations of the traditional dipole source localization method [14].…”

Section: Introductionmentioning

confidence: 99%

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

Pang

Wang

Malone

et al. 2011

Neuroscience Letters

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Functional MRI (fMRI) is routinely used to non-invasively localize language areas. Magnetoencephalography (MEG) is being explored as an alternative technique. MEG tasks to localize receptive language are well established although there are no standardized tasks to localize expressive language areas. We developed two expressive language tasks for MEG and validated their localizations against fMRI data. Ten right-handed adolescents (μ=17.5 years) were tested with fMRI and MEG on two tasks: verb generation to pictures and verb generation to words. MEG and fMRI data were normalized and overlaid. The number of overlapping voxels activated in fMRI and MEG were counted for each subject, for each task, at different thresholding levels. For picture verb generation, there was 100% concordance between MEG and fMRI lateralization, and for word verb generation, there was 75% concordance. A count showed 79.6% overlap of voxels activated by both MEG and fMRI for picture verb generation and 50.2% overlap for word verb generation. The percentage overlap decreased with increasingly stringent activation thresholds. Our novel MEG expressive language tasks successfully identified neural regions involved in language production and showed high concordance with fMRI laterality. Percentage overlap of activated voxels was also high when validated against fMRI, but showed task-specific and threshold-related effects. The high concordance and high percentage overlap between fMRI and MEG activations confirm the validity of our new MEG task. Furthermore, the higher concordance from the picture verb generation task suggests that this is a promising task for use in the young clinical population.

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“…The word recognition task was also recently used in a series of experiments to evaluate the reliability of brain activation profiles obtained using an automated analysis procedure for MEG (Papanicolaou et al, 2006). Brain activation profiles reliably showed bilateral activity in the superior temporal gyrus (STG), and activity in the middle temporal gyrus (MTG) lateralized to the left hemisphere.…”

mentioning

confidence: 99%

A comparison of functional MRI and magnetoencephalography for receptive language mapping

Billingsley-Marshall

Clear

Mencl

et al. 2007

Journal of Neuroscience Methods

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Functional neuroimaging with MEG: Normative language profiles

Cited by 61 publications

References 38 publications

Objective phonological and subjective perceptual characteristics of syllables modulate spatiotemporal patterns of superior temporal gyrus activity

Objective phonological and subjective perceptual characteristics of syllables modulate spatiotemporal patterns of superior temporal gyrus activity

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

A comparison of functional MRI and magnetoencephalography for receptive language mapping

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