Functional Neurological Symptom Disorder in Williams Syndrome: Case Series and Review of Relevant Literature

Thom, Robyn P.; Balaj, Kayla; Keary, Christopher J.; Pober, Barbara R.; McDougle, Christopher J.

doi:10.1016/j.jaclp.2021.09.007

Cited by 1 publication

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References 28 publications

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“…High rates of anxiety disorders in Williams syndrome, well beyond the expected baseline rate seen in individuals with other causes of intellectual disability, have also been established [9]. In addition to these well recognized behavioral and psychiatric features of Williams syndrome, the full range of psychopathology has been observed in our clinical population, including but not limited to attentiondeficit/hyperactivity disorder, sleep disorders, unipolar and bipolar mood disorders, functional neurological symptom disorder [10], substance use disorders, and schizophrenia. Common psychiatric symptom targets and the available evidence on the use of psychopharmacology in Williams syndrome have previously been reviewed in Thom et al [11].…”

Section: Introductionmentioning

confidence: 90%

Psychiatric and behavioral manifestations of Williams syndrome

Thom

2023

Current Opinion in Psychiatry

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Purpose of review The purpose of this review is to synthesize recent advances in the psychiatric and behavioral manifestations of Williams syndrome, a rare genetic syndrome. Recent advances have focused on more deeply characterizing the social phenotype and developing social skill interventions, improving the assessment and treatment of anxiety, and exploring eating behaviors. Recent findings The social cognitive phenotype in Williams syndrome, which consists of both high social drive and social cognition deficits, is present cross-culturally and may be related to reduced eye gaze. Social skills training for adults with Williams syndrome has demonstrated promise. Adapted exposure therapy and cognitive behavioral therapy programs for children and adults respectively, have been piloted in Williams syndrome. The majority of adults with Williams syndrome are either underweight or overweight, and problematic food-related behaviors likely contribute to bodyweight status. Summary Williams syndrome is associated with a number of core social and psychiatric difficulties which have a significant impact on functioning and quality of life. Recent work has begun to utilize a more nuanced understanding of the clinical presentations of these problems to develop interventions tailored to this unique population. However, larger trials, particularly those inclusive of a more diverse Williams syndrome population, are needed.

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Section: Introductionmentioning

confidence: 90%

Psychiatric and behavioral manifestations of Williams syndrome

Thom

2023

Current Opinion in Psychiatry

View full text Add to dashboard Cite

show abstract

Functional Neurological Symptom Disorder in Williams Syndrome: Case Series and Review of Relevant Literature

Cited by 1 publication

References 28 publications

Psychiatric and behavioral manifestations of Williams syndrome

Psychiatric and behavioral manifestations of Williams syndrome

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