Functional organization of olfactory processing in the accessory lobe of the spiny lobster

Wachowiak, Matt; Diebel, Carol E.; Ache, Barry W.

doi:10.1007/bf00188163

Cited by 51 publications

(85 citation statements)

References 21 publications

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“…In contrast to the results obtained in crayfish, Schmidt (2001) concluded that nearly all adult-born cells in cluster 10 of P. argus remain within a portion of the cluster comprised mainly of OL projection neuron somata (Wachowiak and Ache 1994;Schmidt and Ache 1996;Wachowiak et al 1996), suggesting that most newborn cells in this species differentiate into OL projection neurons. While the functional importance of life-long neurogenesis in the olfactory pathways of decapod crustaceans remains unknown, these results suggest that its roles may differ amongst decapod taxa.…”

Section: Differentiation Of Newborn Cells In the Lpz (Cluster 10): Prcontrasting

confidence: 63%

“…7A, B). As described above, although most neurons in cluster 10 express crustacean-SIFamide, the cluster is comprised of at least two classes of neurons: OL projection neurons and AL projection neurons (Wachowiak et al 1996;Sullivan and Beltz 2005b). These two neuronal classes have distinct structural and functional identities, OL projection neurons innervating the primary olfactory neuropil (the OL) and AL projection neurons innervating a higher-order multimodal neuropil (the AL).…”

Section: Differentiation Of Newborn Cells In the Lpz (Cluster 10): Prmentioning

confidence: 99%

“…The OL glomeruli are sites of synaptic contact between the ORNs, olfactory projection neurons and several classes of local interneurons. In crayfish and lobsters, the latter two classes of neurons also innervate an additional glomerular neuropil, the accessory lobe (AL), which lies adjacent to the OL (Arbas et al 1988;Mellon and Alones 1994;Wachowiak et al 1996;Sullivan et al 2000;Beltz 2001a,b, 2005b). In contrast to the OL, which receives only primary olfactory inputs, the AL receives higher-order olfactory, visual and mechanosensory inputs Sullivan and Beltz 2005b).…”

Section: Introductionmentioning

confidence: 99%

“…Anatomical studies in eureptantian decapods have shown that individual cluster 10 projection neurons innervate either the OL or the AL (Wachowiak and Ache 1994;Schmidt and Ache 1996;Wachowiak et al 1996;Sullivan et al 2000). Cluster 10 in these animals, therefore, is comprised of at least two groups of interneurons (OL projection neurons, AL projection neurons) with distinct functional identities .…”

Section: Introductionmentioning

confidence: 99%

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Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

et al. 2007

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Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells migrate during S and G 2 stages of the cell cycle along glial fibers to lateral (cluster 10) and medial (cluster 9) proliferation zones. Here, they divide (M phase) producing offspring that differentiate into olfactory interneurons. The complete lineage of cells producing neurons in these animals, therefore, is arranged along the migratory stream according to cell cycle stage. We have exploited this model to examine the influence of environmental and endogenous factors on adult neurogenesis. We find that increased levels of serotonin upregulate neuronal production, as does maintaining animals in an enriched (versus deprived) environment or augmenting their diet with omega-3 fatty acids; increased levels of nitric oxide, on the other hand, decrease the rate of neurogenesis. The features of the neurogenic niche and migratory streams, and the fact that these continue to function in vitro, provide opportunities unavailable in other organisms to explore the sequence of cellular and molecular events leading to the production of new neurons in adult brains.

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Section: Differentiation Of Newborn Cells In the Lpz (Cluster 10): Prcontrasting

confidence: 63%

Section: Differentiation Of Newborn Cells In the Lpz (Cluster 10): Prmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

et al. 2007

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“…The paired ALs in crustaceans receive no primary sensory input but rather receive projections of local interneurons in clusters 9 and 11 that carry higher-order visual, mechanosensory and olfactory information Wachowiak et al, 1996; J. M. Sullivan and B. S. Beltz, unpublished results). The AL output is carried by the axons of the cluster 10 projection neurons, which continue to proliferate throughout the animal's life (Harzsch et al, 1999;Benton and Beltz, 2002) and which project to the hemiellipsoid bodies located in the lateral protocerebrum ).…”

Section: Serotonergic Rhythms In the Olfactory And Accessory Lobesmentioning

confidence: 97%

Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

Wildt

Goergen

Benton

et al. 2004

Journal of Experimental Biology

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This study examined whether serotonin levels in the brain of the American lobster, Homarus americanus, are under circadian control. Using high-performance liquid chromatography and semi-quantitative immunocytochemical methods, we measured serotonin levels in the brains of lobsters at six time points during a 24-h period. Lobsters were maintained for 2·weeks on a 12·h:12·h light:dark cycle followed by 3·days of constant darkness. Under these conditions, brain serotonin levels varied rhythmically, with a peak before subjective dusk and a trough before subjective dawn. This persistent circadian rhythm in constant darkness indicates that serotonin levels are controlled by an endogenous clock. Animals exposed to a shifted light cycle for >10·days, followed by 3·days in constant darkness, demonstrate that this rhythm is light entrainable. Separate analyses of two pairs of large deutocerebral neuropils, the accessory and olfactory lobes, show that serotonin levels in these functionally distinct areas also exhibit circadian rhythms but that these rhythms are out of phase with one another. The olfactory and accessory lobe rhythms are also endogenous and light entrainable, suggesting the presence of multiple clock mechanisms regulating serotonin levels in different brain regions.

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Serotonin depletion by 5,7-dihydroxytryptamine alters deutocerebral development in the lobster,Homarus americanus

et al. 1997

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The olfactory and accessory lobes constitute prominent histological structures within the larval and mature lobster deutocerebrum, and both are associated with a dense innervation from paired serotonergic nerve cells, the dorsal giant neurons (DGNs). During development, the cell bodies of the DGNs are the first central somata to express serotonin (5‐HT), and the onset of their 5‐HT immunoreactivity coincides with the beginning of accessory lobe formation. In contrast, the olfactory lobe anlagen emerge much earlier and grow in the apparent absence of serotonin. The role of serotonergic input for the development of these brain structures was investigated in lobster embryos after serotonin had been depleted pharmacologically with the neurotoxin 5,7‐dihydroxytryptamine. A ∼90% reduction of serotonin was confirmed in eggs using high‐performance liquid chromatography with electrochemical detection. Morphometric analyses suggested that serotonin depletion dramatically slowed the growth of olfactory and accessory lobes, although glomeruli differentiated at the normal time in both areas. The toxin exhibited a high degree of specificity for serotonergic neurons and associated target regions, and serotonin depletion persisted for at least 2 months following treatment. The goal of future experiments is to determine which of the cell types that innervate the olfactory and accessory lobes are affected by toxin treatment, thereby resulting in the retarded growth of these areas. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 357–373, 1997

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Functional organization of olfactory processing in the accessory lobe of the spiny lobster

Cited by 51 publications

References 21 publications

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons

Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

Serotonin depletion by 5,7-dihydroxytryptamine alters deutocerebral development in the lobster,Homarus americanus

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