1979
DOI: 10.1002/cne.901850407
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Functional organization of rat olfactory bulb analysed by the 2‐deoxyglucose method

Abstract: The spatial patterns of activity elicited in the rat olfactory bulb under different odor conditions have been analysed using the 2-deoxyglucose (2DG) technique. Rats were injected with 14C-2DG, exposed to controlled environments of amyl acetate, camphor, cage air, dimethyl disulfide, and pure air and autoradiographs prepared by the method of Sokoloff. Amyl acetate was associated with regions of glomerular layer densities in the anterolateral and mid- to posteromedial parts of the bulbar circumference, as previ… Show more

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Cited by 386 publications
(216 citation statements)
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“…This is inferred from the observation that total glomerular activation increases with odor concentration (Stewart et al, 1979;Meister and Bonhoeffer, 2001), and from unpublished results from our group indicating that a minimal number of (simultaneous) stimulated ORNs stimuli is needed to activate a given target cell (A. V. Masurkar, W. R. Chen, personal communication), hence implying that target cell recruitment is a step function of ORN recruitment.…”
Section: Canonical Energy Calculationsmentioning
confidence: 86%
“…This is inferred from the observation that total glomerular activation increases with odor concentration (Stewart et al, 1979;Meister and Bonhoeffer, 2001), and from unpublished results from our group indicating that a minimal number of (simultaneous) stimulated ORNs stimuli is needed to activate a given target cell (A. V. Masurkar, W. R. Chen, personal communication), hence implying that target cell recruitment is a step function of ORN recruitment.…”
Section: Canonical Energy Calculationsmentioning
confidence: 86%
“…Because sensory axons converging on a single glomerulus outnumber principal cells by a factor of several hundred and because action potentials are predicted to consume a major part of the energy budget during signaling (48), our study raises the question of how energy is distributed to olfactory nerve axons, whatever the percentage of them is activated during odor stimulation. Studies based on 2-deoxyglucose consumption (32,33,49) clearly demonstrated that energy consumption is significant in the ONL. It is thus possible that the oxygen present in the immediate vicinity of arterioles (50) contributes to the oxygen supply of the ONL.…”
Section: Discussionmentioning
confidence: 99%
“…As a result, odor stimulation reproducibly activates small glomeruli ensembles. These patterns of glomerular activation have been revealed by several methods including (i) BOLD fMRI (18)(19)(20), (ii) optical imaging of calcium (21), voltage (22), and intrinsic signals (23)(24)(25)(26)(27)(28), (iii) electrophysiological recordings (29)(30)(31), and (iv) measurements of 2-deoxyglucose consumption (32,33). Here, we use two-photon imaging to determine with a high spatial resolution the relationship between RBC flow in individual capillaries and neuronal activation.…”
mentioning
confidence: 99%
“…98,99. These latter approaches have not yet had adequate controls done for individual variability; they permit only one odorant for each subject.…”
Section: Spatial Analysis In the Olfactory Bulbmentioning
confidence: 99%