Functional Organization of Spinocerebellar Paths

Oscarsson, O.

doi:10.1007/978-3-642-65438-1_12

Cited by 181 publications

(81 citation statements)

References 131 publications

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“…This discharge did not follow a stimulation frequency above 10 Hz and is most probably due to a dorsal root reflex discharge (Toennies, 1938) of climbing fibre responses (Fig. 2F) (Oscarsson, 1973). In some experiments the late field potential mainly consisted of the negative potential (see Fig.…”

Section: Resultsmentioning

confidence: 94%

“…The A,8-fibre-evoked climbing fibre responses from the ipsilateral forelimb are mediated by spino-olivo-cerebellar pathways ascending in the dorsal funiculus and the dorsolateral funiculus (Oscarsson, 1973). Very little is known about the spinal pathways responsible for the C-fibre-evoked climbing fibre responses.…”

Section: Discussionmentioning

confidence: 99%

“…Oscarsson, 1973;Ekerot & Larson, 1979a). Field potentials were recorded from the surface of the cerebellum using a ball-tipped electrode (tip diameter about 0-2 mm).…”

Section: Recording and Identification Of Cerebellar Sagittal Zonesmentioning

confidence: 99%

“…However, no attempt was made to determine whether impulses in mossy fibres or climbing fibres mediated these responses, nor was the projection determined with respect to the sagittally arranged functional zones of the cerebellum (Oscarsson, 1973(Oscarsson, , 1980Ekerot & Larson, 1979a). In the present study similar long-latency surface potentials on C-fibre stimulation were explored in the C 3 zone of the anterior lobe and identified as climbing fibre responses.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that climbing fibres receive excitation from low-threshold cutaneous mechanoreceptors and group II muscle afferents (Eccles, Sabah, Schmidt & Taborikova, 1972;Leicht, Rowe & Schmidt, 1973;Oscarsson, 1973). Very little is known about a possible input to the climbing fibres from cutaneous unmyelinated (C) fibres, which outnumber the myelinated fibres in cutaneous nerves (Langford, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres.

Ekerot

Gustavsson

Oscarsson

et al. 1987

The Journal of Physiology

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SUMMARY1. Climbing fibre responses evoked on stimulation of the ipsilateral superficial radial nerve were examined in the forelimb area of the C3 zone in the barbiturateanaesthetized cat. Climbing fibre responses were recorded in sixty-five Purkinje cells and as field potentials from the surface of the cerebellum. 3. The long-latency climbing fibre response generated by electrical stimulation at C-fibre strength was evoked also during selective anodal block of conduction in A fibres (Brown & Hamman, 1972). Hence, impulses in C fibres were sufficient for generation of climbing fibre responses.4. The distribution within the forelimb area of the C 3 zone of the A/I-and C-fibre-evoked climbing fibre field potential was similar. No climbing fibre response was evoked in this area of the C 3 zone by stimulation of A and C fibres in the contralateral superficial radial nerve or in the plantar nerves of the hind limbs.5. It can be concluded that climbing fibres projecting to the forelimb area of the C 3 zone in the cerebellum receive a somatotopically organized input from both A/I and C fibres.

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Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

“…Oscarsson, 1973;Ekerot & Larson, 1979a). Field potentials were recorded from the surface of the cerebellum using a ball-tipped electrode (tip diameter about 0-2 mm).…”

Section: Recording and Identification Of Cerebellar Sagittal Zonesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres.

Ekerot

Gustavsson

Oscarsson

et al. 1987

The Journal of Physiology

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Projections from the cervical enlargement to the cerebellar nuclei in the rat, studied by anterograde axonal tracing

Matsushita

Xiong

1997

J. Comp. Neurol.

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Spinocerebellar projections from the cervical enlargement originate from neurons in the medial part of lamina VI and the central part of lamina VII. In the present study, the topographic projections of the cervical enlargement to the cerebellar nuclei were examined by anterograde tracing with biotinylated dextran in the rat. Following injections of the tracer into the spinal cord at levels between the C5 and T1 segments, anterogradely labeled axons and terminals were immunohistochemically demonstrated in the cerebellar nuclei. Unilateral injections revealed that projections are bilateral, but predominantly ipsilateral, to the cells of origin. Labeled axons entered the media nucleus from its rostrodorsal and rostromedial aspects. Labeled terminals were distributed to dorsal and medial parts of the middle subdivision at its rostral levels and to medial parts of the caudomedial subdivision of the medial nucleus. Most axons terminated in the middle subdivision. Single axons were seen to course rostrocaudally in the medial nucleus and give off terminal axons to both subdivisions. A few labeled terminals were seen in the dorsolateral protuberance of the medial nucleus, and in the anterior interpositus and the posterior interpositus nuclei. No labeled terminals were seen in the lateral cerebellar nucleus. The present study demonstrates that spinocerebellar neurons in laminae VI and VII of the cervical enlargement project to dorsomedial areas of the medial nucleus at rostral levels, bilaterally but predominantly ipsilaterally. It is suggested that these areas specifically receive cutaneous and muscular input related to the forelimb movement.

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Chondroitin sulfate proteoglycan specific to retinal horizontal neurons

et al. 1998

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Proteoglycans (PGs) are a diverse group of highly glycosylated macromolecules that are implicated in the development and maintenance of neuronal circuitry. With its highly ordered, layered structure, the retina ideally serves to define the synthesis, processing, and distribution of these molecules within a specific cellular subpopulation. In retinal sections, monoclonal antibody (MAb) 6A2 immunostained a horizontal cell-specific antigen. Antigen 6A2 was expressed within abundant processes in the outer plexiform layer and in rare neurites that extend across the inner nuclear layer to the inner plexiform layer. Ultrastructurally, the antigen was localized to cisternae within horizontal cell somata, along tubulovesicular structures in dendrites, and in the perisynaptic space encircling presynaptic terminals of the cone photoreceptor triad. These findings suggest that this PG is synthesized within the horizontal cells, transported to the terminals, and released into the extracellular spaces just proximal to the synapse. Based on the focal stain in the adjacent photoreceptor cell, it is possible that antigen is pinocytosed by this cell and is concentrated at the ribbon synapse. In Western immunoblots of retinal homogenates, MAb 6A2 recognized a heterogeneous chondroitin sulfate (CS) PG (CSPG) of approximately 400-500 kDa. After sequential enzymatic removal of CS glycosaminoglycans, a major broad band of 300-500 kDa was identified by MAb 1B5, which detects CSPGs that bear uronic acid linked to unsulfated N-acetylgalactosamine as the initial disaccharide in the CS chain. Localization of this PG around presynaptic terminals of the horizontal neuron and at the ribbon synapse suggests that it may play a modulatory and sustaining role at the synapse.

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Functional Organization of Spinocerebellar Paths

Cited by 181 publications

References 131 publications

Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres.

Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres.

Projections from the cervical enlargement to the cerebellar nuclei in the rat, studied by anterograde axonal tracing

Chondroitin sulfate proteoglycan specific to retinal horizontal neurons

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