Functional outcome after neonatal pyeloplasty in antenatally diagnosed uretero-pelvic junction obstruction

Bendre, Pradnya; Karkera, Parag; Nanjappa, Monita

doi:10.1186/s12301-021-00121-5

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…There was a study on neonatal pyeloplasty outcomes by Bendre et al . [ 11 ] that showed improvement in SRF from 35.48% to 44.7% in neonates with a mean age of 26 days. In our study, the youngest infant was 28 days old, which showed a drastic improvement in SRF from 29% to 50%.…”

Section: Discussionmentioning

confidence: 99%

Does Age Influence the Functional Recovery after Infant Pyeloplasty?

Tharanendran,

Sundararajan,

Babu

et al. 2024

Journal of Indian Association of Pediatric Surgeons

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Purpose: The purpose was to study the correlation between age at surgery and functional recovery after infant pyeloplasty. Materials and Methods: All infants who underwent pyeloplasty were analyzed retrospectively in this multicenter study. Anteroposterior diameter (APD) >2 cm, split renal function (SRF) <40%, and Society of Fetal Urology (SFU) grade 3–4 were surgical indications. Based on the age at pyeloplasty, they were divided into Group 1 (1–3 months) and Group 2 (4–12 months). APD and SRF were compared before and after surgery in both groups. The fractional recoverable function (post-SRF-pre-SRF)/(50-pre-SRF) ×100 was correlated with age. Results: Fifty-one infants underwent pyeloplasty (mean age: 1.6 months – Group 1 and 7.2 months – Group 2). The mean APD decreased from 3 cm to 1.2 cm in Group 1 while 2.8 cm to 2 cm in Group 2 (P = 0.001). The mean SRF increased from 32.28% to 42.81% in Group 1 while 31%–34.18% in Group 2. SRF recovery was significantly higher in Group 1 compared to Group 2 (P = 0.001). Regression analysis showed a weak negative correlation (r = −0.2792) between age at surgery and renal function improvement. Conclusion: Functional recovery after pyeloplasty is better when done earlier (1–3 months), as this gives the growing kidney the best opportunity to recover.

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Section: Discussionmentioning

confidence: 99%

Does Age Influence the Functional Recovery after Infant Pyeloplasty?

Tharanendran,

Sundararajan,

Babu

et al. 2024

Journal of Indian Association of Pediatric Surgeons

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Long-term treatment results of hydronephrosis in children operated in their first year of life. A systematic review

Bebenina,

Mokrushina,

Levitskaya

et al. 2023

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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BACKGROUND: Congenital stenosis of the ureterоpelvic junction is the most common cause of hydronephrosis in children. AIM: This systematic review aimed to search and analyze modern literature from 1998 to 2021 on the treatment and postoperative follow-up of children with severe hydronephrosis in the first year of life and study the long-term results. MATERIALS AND METHODS: Literary sources were searched in PubMed, Web of Science, Scopus, Google Scholar, and eLibrary databases. The following keywords were used to search for English sources: congenital hydronephrosis, severe hydronephrosis, operative treatment, uretero-pelvic junction obstruction infant, children, neonatal, and infancy. Five full-text articles that meet the criteria were included for analysis. RESULTS: A total of 355 patients were included in the publications. Antenatal screening was described only in two studies. The average age of children at the time of surgery was five months (one to six months). All the authors noted that due to pyeloplasty in the first year of life, the renal parenchyma exhibited a significant increase in thickness; the indicators in dynamics increased by an average of 1.5 times during the year. The size of the renal pelvis decreased by 50%67%. The data of radioisotope scintigraphy were variable; however, in the long-term period, improvement in renal function was noted in all publications. CONCLUSIONS: This systematic review shows the long-term results of early pyeloplasty in congenital hydronephrosis in young children. A significant decrease in the pelvis and an increase in the thickness of the parenchyma were observed, both of which are an advantage for the restoration of renal function. However, no single algorithm can predict the recovery of renal parenchyma. An accurate assessment of renal parenchymal function should be confirmed by a prospective, randomized, long-term, follow-up study with a large number of cases.

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Functional outcome after neonatal pyeloplasty in antenatally diagnosed uretero-pelvic junction obstruction

Cited by 2 publications

References 22 publications

Does Age Influence the Functional Recovery after Infant Pyeloplasty?

Does Age Influence the Functional Recovery after Infant Pyeloplasty?

Long-term treatment results of hydronephrosis in children operated in their first year of life. A systematic review

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