Functional outcome of macular edema in different retinal disorders

Tomkins-Netzer, Oren; Ismetova, Filis; Bar, Asaf; Seguin-Greenstein, Sophie; Kramer, Michal; Lightman, Sue

doi:10.1016/j.preteyeres.2015.05.002

Cited by 30 publications

(28 citation statements)

References 166 publications

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“…10 Outcomes secondary to macular edema often vary, with some eyes demonstrating no change over long-term follow-up, whereas other eyes demonstrate pronounced VA impairment on presentation. 16 This could be the result of variation in the distortion of the individual retinal layers secondary to the edema. 16 Therefore, the significant decline in vision in our cohort also could be accounted for in part by the increased incidence of TRD and NVG, rather than just worsening edema.…”

Section: Discussionmentioning

confidence: 99%

“…16 This could be the result of variation in the distortion of the individual retinal layers secondary to the edema. 16 Therefore, the significant decline in vision in our cohort also could be accounted for in part by the increased incidence of TRD and NVG, rather than just worsening edema. This is particularly relevant as practice patterns start to shift toward anti-VEGF monotherapy for eyes with PDR.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti–Vascular Endothelial Growth Factor

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti–Vascular Endothelial Growth Factor

et al. 2019

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“…Macular oedema is characterised by accumulation of extracellular fluid between the retinal (inner nuclear and outer plexiform) layers, forming extracellular oedema, or inside the cells, forming intracellular oedema (Muller cells) [1,2]. Therefore, macular oedema can be categorised as cytotoxic (intracellular) or vasogenic (extracellular).…”

Section: Introductionmentioning

confidence: 99%

Long-term efficacy and duration of action of dexamethasone implant, in vitrectomised and non-vitrectomised eyes with persistent diabetic macular oedema

Bastakis

Dimopoulos

Stavrakakis

et al. 2018

Eye

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Purpose To evaluate the efficacy and duration of action of an intravitreal (dexamethasone (Ozurdex)) implant in vitrectomised and non-vitrectomised eyes with persistent diabetic macular oedema (DMO). Methods We retrospectively analysed the records for 18 eyes that had or had not been vitrectomised but required an intravitreal dexamethasone implant for DMO after a poor response to anti-vascular endothelial growth factor. Optical coherence tomography and visual acuity (VA) examinations were performed before and 1, 3 and 6 months after implantation. The six months following implantation constituted one treatment round; up to three rounds were studied. Results Ten of 18 eyes had undergone vitrectomy. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were significantly improved by months 1-3 after implantation of the Ozurdex device in all rounds of treatment. The BCVA and CMT deteriorated gradually after month 3 through to month 6 post implantation. There were no statistically significant differences between the vitrectomised and non-vitrectomised groups at any time point. When the implantation interval was <6 weeks from the end of each treatment round, the improvement in BCVA and CMT was obvious even after 18 months of treatment. Conclusions Vitrectomy did not have a negative effect on the duration of action or efficacy of the Ozurdex implant in patients with persistent DMO. The implant started working from the first month after implantation regardless of whether vitrectomy had or had not been performed. The maximum functional and anatomic improvement was achieved in the first 3 months post implantation in all treatment rounds.

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“…However, in our study, a severely decreased retinal sensitivity was observed irrespective of ILM-peeling. Visual acuity (VA) testing relies on the ability to resolve a spatial pattern, while retinal sensitivity tested by microperimetry is based on the ability to discriminate signals of low contrast (Tomkins-Netzer et al 2015). Intraocular SO may influence these features of visual function differently.…”

Section: Discussionmentioning

confidence: 99%

Retinal sensitivity following intraocular silicone oil and gas tamponade for rhegmatogenous retinal detachment

Scheerlinck

Schellekens

Liem

et al. 2018

Acta Ophthalmologica

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Functional outcome of macular edema in different retinal disorders

Cited by 30 publications

References 166 publications

Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti–Vascular Endothelial Growth Factor

Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti–Vascular Endothelial Growth Factor

Long-term efficacy and duration of action of dexamethasone implant, in vitrectomised and non-vitrectomised eyes with persistent diabetic macular oedema

Retinal sensitivity following intraocular silicone oil and gas tamponade for rhegmatogenous retinal detachment

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