Functional Outcomes and Participation in Young Adulthood for Very Preterm and Very Low Birth Weight Infants: The Dutch Project on Preterm and Small for Gestational Age Infants at 19 Years of Age

Hille, E.T.M.; Weisglas‐Kuperus, Nynke; Goudoever, Johannes B. van; Jacobusse, G.W.; Ens-Dokkum, M.H.; Groot, Laila de; Wit, Jan-Maarten; Geven, W.B.; Kok, Joke H.; Kleine, Martin J. K. de; Kollée, L.A.A.; Mulder, A. L. M.; Straaten, H.L.M. van; Vries, Linda S. de; Weissenbruch, Mirjam M. van; Verloove-Vanhorick, S.P.

doi:10.1542/peds.2006-2407

Cited by 161 publications

(122 citation statements)

References 40 publications

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“…[41][42][43][44] The study that is most similar to ours is the Netherlands Project on Preterm and Small for Gestational Age Infants study in VLBW/VP infants born in 1983. 45,46 As in our study, Hille et al, 46 reporting from the POPS study cohort at age 19 years, found that VLBW survivors had greater difficulty establishing social contacts but did not have elevated risks of psychopathology compared with their term-born peers.…”

Section: Discussionsupporting

confidence: 67%

Psychosocial Outcomes of Young Adults Born Very Low Birth Weight

Darlow¹,

Horwood

Pere-Bracken³

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Several studies have suggested that very low birth weight young adults have increased risks of physical and health problems, educational underachievement, and poorer social functioning than their peers, but there are limited population-based and longitudinal data.WHAT THIS STUDY ADDS: Former VLBW young adults in this national cohort scored as well as term controls on many measures of health and social functioning, including quality-of-life scores, with some differences largely confined to those with disability at age 7 to 8 years.abstract OBJECTIVE: To assess the early adult health, education, and social functioning of a national cohort of very low birth weight (VLBW) infants born in 1986 in New Zealand compared with a control group of young adults born the same year. The impact of neurodevelopmental disability at age 7 to 8 years on young adult outcomes was examined.METHODS: Participants underwent a comprehensive face-to-face interview that included standardized assessment tools and previously used custom written survey items. RESULTS:We interviewed 230 VLBW young adults (71% of survivors) and 69 controls at age 22 to 23 years. VLBW young adults were 5.6 kg lighter and 4.2 cm shorter than controls, had lower rates of tertiary education/ training (percentage difference [95% confidence interval]: 213.1 [221.6 to 21.8]) and university degree completion (215.6 [228.0 to 24.8]), had more often been welfare dependent (23.5 [10.2 to 35.0]), had few or no friends (20.5 [7.2 to 32.2]), and more often had wheeze in the past year (20.1 [9.0 to 28.6]). However, in many areas there were no differences between the VLBW cohort and controls, and VLBW adults rated their overall quality of life and behavioral functioning similarly to their peers. Those with previous disability had poorer social, occupational, and physical functioning than other VLBW young adults.CONCLUSIONS: Despite some evidence of health, educational, and social difficulties, former VLBW young adults obtained similar scores across many aspects of health and social functioning as their same age peers, with some differences largely confined to those with previous disability.

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Section: Discussionsupporting

confidence: 67%

Psychosocial Outcomes of Young Adults Born Very Low Birth Weight

Darlow¹,

Horwood

Pere-Bracken³

et al. 2013

Pediatrics

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“…[1][2][3][4]6,42 In the general population, low childhood IQ has been found to predict low adult SES, 43,44 as well as reduced survival and health into old age. 45,46 IQ is thus an important marker of brain health.…”

Section: Figurementioning

confidence: 99%

Preterm Cognitive Function Into Adulthood

Breeman¹,

Jaekel

Baumann³

et al. 2015

Pediatrics

168

155

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, Dieter Wolke, PhD, Dr rer nat hc a,d abstract BACKGROUND: Very preterm (VP; gestational age ,32 weeks) and very low birth weight (VLBW; ,1500 g) births are related to impaired cognitive function across the life span. It is not known how stable cognitive functions are from childhood to adulthood for VP/VLBW compared with term-born individuals and how early adult cognitive function can be predicted.

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“…The incidence of preterm birth has increased significantly in the past decades, but is associated with higher survival rates 1 and a lower incidence of major disabilities than in the past. 2 However, there is strong evidence that preterm survivors without brain malformations, congenital infection, or metabolic disease and with normal outcomes or mild abnormalities on structural brain magnetic resonance imaging (MRI) may experience more problems of motor, cognitive, language, and behavioural functioning throughout childhood and young adulthood. [3][4][5][6] These sequelae have been attributed to perinatal brain injuries, 7,8 which frequently involve white matter, 9 during normal brain maturation.…”

Section: Interpretation Significant Changes In Fractional Anisotropy mentioning

confidence: 99%

Fractional anisotropy alterations in individuals born preterm: a diffusion tensor imaging meta‐analysis

Sun

Han

et al. 2014

Develop Med Child Neuro

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ALEActivation likelihood estimate DTI Diffusion tensor imaging SMD Standardized mean difference AIM This meta-analysis explored cerebral microstructural changes in individuals born preterm using fractional anisotropy from diffusion tensor imaging.METHOD We used the activation likelihood estimate (ALE) method for the meta-analysis to locate anatomical regions with white matter abnormalities in a group of individuals born preterm and in term-born comparison participants. A statistical analysis of fractional anisotropy was conducted to quantitatively explore the extent of fractional anisotropy changes in the three subregions of the corpus callosum in the preterm group.RESULTS ALE analysis identified 11 regions of decreased fractional anisotropy and four regions of increased fractional anisotropy. Analysis of the corpus callosum revealed the largest decrease in fractional anisotropy in the splenium (standardized mean difference [SMD]=À0.75, 95% confidence interval [CI] À0.93 to À0.57), followed by the body (SMD=À0.73, 95% CI À1.13 to À0.32) and the genu (SMD=À0.65, 95% CI À0.97 to À0.33). INTERPRETATION Significant changes in fractional anisotropy in individuals born pretermreflect white matter abnormalities from childhood to young adulthood, and the mechanism of fractional anisotropy alterations in preterm infants may vary during different stages of white matter development. Furthermore, the variability of fractional anisotropy between studies can primarily be attributed to the age of the individuals at scanning and to the field strength of magnetic resonance scanners.Preterm birth is frequently accompanied by a variety of disabilities, such as cerebral palsy, intellectual disability, deafness, or blindness. The incidence of preterm birth has increased significantly in the past decades, but is associated with higher survival rates 1 and a lower incidence of major disabilities than in the past.2 However, there is strong evidence that preterm survivors without brain malformations, congenital infection, or metabolic disease and with normal outcomes or mild abnormalities on structural brain magnetic resonance imaging (MRI) may experience more problems of motor, cognitive, language, and behavioural functioning throughout childhood and young adulthood. [3][4][5][6] These sequelae have been attributed to perinatal brain injuries, 7,8 which frequently involve white matter, 9 during normal brain maturation. 10 Nevertheless, the location, severity, and mechanism of white matter injuries on neurodevelopment and their impact on future function have not been conclusively determined.11 Additional neuroimaging evidence is necessary to explain the mechanism of white matter injuries and to predict the future influence of these impairments in individuals who are born preterm.Diffusion tensor imaging (DTI), a novel MRI technique, can quantify the fibre orientation and integrity of white matter pathways within neural networks. This technique is superior to conventional MRI methods for the detection of white matter abnormalities becaus...

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Functional Outcomes and Participation in Young Adulthood for Very Preterm and Very Low Birth Weight Infants: The Dutch Project on Preterm and Small for Gestational Age Infants at 19 Years of Age

Cited by 161 publications

References 40 publications

Psychosocial Outcomes of Young Adults Born Very Low Birth Weight

Psychosocial Outcomes of Young Adults Born Very Low Birth Weight

Preterm Cognitive Function Into Adulthood

Fractional anisotropy alterations in individuals born preterm: a diffusion tensor imaging meta‐analysis

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