Functional polymorphism of PIN1 rs2233679 is associated with the progression of CIN to early cervical cancer in Hunan Chinese

Wang, Kangtao; Fan, Jielin; Lin, Wei‐Ting; Zou, Chun; He, Mei; Cai, Yubo; Pei, Haiping; Li, Ming

doi:10.1016/j.tjog.2020.01.001

Cited by 1 publication

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“…As for the pathogenesis of CIN, it is still unclear. Some studies believe that renal blood flow reduction, especially renal medulla ischemia, direct cytotoxicity, and the osmotic pressure and viscosity of the contrast agent play an important role in the pathogenesis of CIN [12][13][14]. At present, it is believed that the original renal insufficiency is the most important risk factor for the occurrence of CIN.…”

Section: Introductionmentioning

confidence: 99%

Artificial Intelligence Algorithm‐Based Computed Tomography Image in Assessment of Acute Renal Insufficiency of Patients Undergoing Percutaneous Coronary Intervention

Zhang

Liu

Tian

2022

Contrast Media & Molecular Imaging

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This study was aimed to analyze the changes in renal function of patients undergoing percutaneous coronary intervention (PCI) surgery and the characteristics of their computed tomography (CT) image based on artificial intelligence algorithms. In this study, 104 patients with coronary atherosclerotic heart disease (CAHD) were treated as the research objects. They were divided into an experimental group (patients who underwent CAG and PCI within 1 week after enhanced coronary CT (ECCT)) and the control group (patients who underwent CAG and PCI within 1–3 weeks after ECCT). Renal imaging scans of patients were performed by CT based on discrete inseparable shear transform (DNST) optimized algorithm, which was named as O-DNST. The results showed that the serum creatinine (Scr), blood urea nitrogen (BUN), and urine protein (UP) levels of patients in the experimental group were significantly higher than those of the control group 24–72 hours after surgery, while the levels of endogenous creatinine clearance (Ccr) and estimated glomerular filtration rate (eGFR) were significantly lower than those of the control group ( P < 0.05). The levels of β2 microglobulin (β2-MG), C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor (TNF-α) in the experimental group were significantly higher than those in the control group 24–72 hours after surgery ( P < 0.05). The incidence of contrast-induced nephropathy (CIN) in the experimental group (15.38%) was significantly higher than that in the control group (5.8%), and the difference was statistically significant ( P < 0.05). The results showed that repeated application of contrast agent in a short period of time can promote the increase of serum inflammation levels in PCI patients, which may be a risk factor for CIN in PCI patients.

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Section: Introductionmentioning

confidence: 99%