Functional Polymorphism Of The Interleukin-1beta Gene Promoter Is Associated With Increased Risk For Cerebral Palsy In Mexican Children With Perinatal Hypoxia-Ischemia Antecedents

Abstract

Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm. Renal handling of albumin and beta-2-microglobulin in neonates. Nephron 68: 212-216. 48. Hentschel R, Lödige B, Bulla M (1996) Renal insufficiency in the neonatal period. Clin Nephrol 46: 54-58. 49. Andreoli SP1 (2004) Acute renal failure in the newborn. Semin Perinatol 28: 112-123. 50. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure -definition, outcome measures, animal models, fluid therapy and information technology needs: The second international Citation: Ryan D, Black M J (2015) Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney. J Neonatal Biol 4: 167.

The role of cytokines and their genetic polymorphism in the development of hypoxic-ischemic encephalopathy among full-term newborn children

“…При исследовании цитокиновой системы у недо-ношенных детей с церебральной ишемией выявлен полиморфизм аллельных вариантов генов ФНО-α - [25,30,44]. Интересно, что в груп-пе доношенных детей с церебральной ишемией но-сительство аллельной частоты IL-1β -511-Т зна-чительно выше по сравнению с недоношенными и группой здоровых детей [48].…”