Functional properties of neurons in cat trigeminal subnucleus caudalis (medullary dorsal horn). II. Modulation of responses to noxious and nonnoxious stimuli by periaqueductal gray, nucleus raphe magnus, cerebral cortex, and afferent influences, and effect of naloxone.

Sessle, B J; Hu, James W.; Dubner, Ronald; Lucier, Gregory E.

doi:10.1152/jn.1981.45.2.193

Cited by 196 publications

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“…[26][27][28][29] Electrical stimulation of PAG or RVM has been shown to reduce the activity of nociresponsive neurons in the spinal trigeminal nucleus. [30][31][32][33][34][35] The PAG receives projections form parts of the forebrain such as insular cortex and the amygdala and from specific projection areas. Chiang et al 36 have shown that the jaw-opening reflex induced by orofacial noxious input can be inhibited by stimulation of the orofacial region in the somatosensory cortex.…”

Section: -18mentioning

confidence: 99%

Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study

Okayasu

Komiyama

Yoshida

et al. 2012

Archives of Oral Biology

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The aim of this study was to examine the effect of chewing efforts on sensory and pain thresholds of the orofacial skin of symptom-free subjects.Fourteen healthy volunteers were recruited. Using a stair-case method, the tactile detection threshold (TDT) and the filament-prick pain detection threshold (FPT) on the cheek skin (CS) and the skin overlying the palm side of the thenar skin (TS) were measured before and after chewing gum for 5 min (Time 1: T1) and keeping the jaw relaxed for 5 min (Time 2: T2) as a control.Both for the test and control situation, the TDT was higher in all measurement sites after 5 min. As for the FPT, the reactions between T1 and T2 were quite opposite: The FPT increased and/or remained stable in T1, while, it decreased at all sites in T2. There were significant session effects (T1-T2) on the FPT at the left CS (P < 0.01), right CS (P < 0.05) and TS (P < 0.05).The increase of TDT after chewing/no chewing could be due to habituation, while the decrease of FPT observed in the control situation might be due to sensitization, respectively. This potential sensitization, however, was not observed after chewing efforts. Further studies are needed to clarify the modulating effect of masticatory function on the trigeminal sensory system.

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Section: -18mentioning

confidence: 99%

Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study

Okayasu

Komiyama

Yoshida

et al. 2012

Archives of Oral Biology

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Section: Trigeminal Nociceptive Pathwaymentioning

confidence: 99%

“…In this study, spV received enhanced input from the sensitized TG, and may further amplify these signals through second-order sensitization. Capsaicin-induced descending inhibition could also influence responses in spV (Hu and Sessle, 1979;Sessle et al, 1981), but was apparently insufficient to neutralize the increase.All stimuli applied to CAP V2 significantly increased activation in thalamus, while Thermal-2 and Brush stimuli increased S1 activation. Previous imaging studies have detected increased stimulus-induced responses in S1 after capsaicin-induced thermal and mechanical allodynia (Lorenz et al, 2002;Maihofner and Handwerker, 2005;Maihofner et al, 2004).…”

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Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: An fMRI study

et al. 2007

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The aim of this study was to differentiate the processing of nociceptive information, matched for pain intensity, from capsaicin-induced hyperalgesic vs. control skin at multiple levels in the trigeminal nociceptive pathway. Using an event-related fMRI approach, 12 male subjects underwent three functional scans beginning 1 hour after topical application of capsaicin to a defined location on the maxillary skin, when pain from capsaicin application had completely subsided. Brush and two levels of painful heat (low -Thermal-1 and high -Thermal-2) were applied to the site of capsaicin application and to the mirror image region on the opposite side. Temperatures for each side were set to evoke perceptually-matched pain (mean temperatures [capsaicin/control]: Thermal-1=38.4/42.8°C; Thermal-2=44.9/47.8°C). We found differences in activation patterns following stimuli to treated and untreated sides in sensory circuits across all stimulus conditions. Across the trigeminal nociceptive pathway, Thermal-2 stimulation of hyperalgesic skin evoked greater activation in trigeminal ganglion and nucleus, thalamus, and somatosensory cortex than the control side. Thus, trigeminal nociceptive regions showed increased activation in the context of perceptually equal pain levels. Beyond these regions, contrast analyses of capsaicin vs. control skin stimulation indicated significant changes in bilateral dorsolateral prefrontal cortex and amygdala. The involvement of these emotion-related regions suggests that they may be highly sensitive to context, such as prior experience (application of capsaicin) and the specific pain mechanism (hyperalgesic vs. normal skin). KeywordsPain; sensitization; dorsolateral prefrontal cortex; amygdala; S1; brush Capsaicin-induced sensitization is considered to be a model for the hyperalgesic and allodynic states observed with neuropathic pain. Sensitization refers to the physiological phenomena of increased neural activity in response to a given stimulus intensity, while allodynia and hyperalgesia refer to perceptual symptoms. Applied topically or injected subcutaneously, capsaicin can produce a temporary state of behavioral hypersensitivity to thermal and Corresponding author: Eric Moulton, PhD P. A.I.N. Group Brain Imaging Center McLean Hospital 115 Mill Street Belmont, MA 02478 Phone: 617-855-2604 Fax: 617-855-3772 emoulton@mclean.harvard.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroimage. Author manuscript; available in PMC 2008 May 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscr...

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“…Several studies have tested the effects of stimulation in analgesia-producing sites of the brainstem on unit activity of cells in the dorsal horn of the spinal cord and homologous portions of the spinal trigeminal nucleus. Cells that respond to noxious stimuli show inhibition under these experimental conditions (see, e.g., Beall, Martin, Applebaum, & Willis, 1976;Carstens, 1982;Gebhart, Sandkiihler, Thalhammer, & Zimmerman, 1983, 1984Gerhart, Wilcox, Chung, & Willis, 1981;Gerhart, Yezierski, Wilcox, & Willis, 1984;Liebeskind et al, 1973;Oliveras et al, 1974;Sessle, Hu, Dubner, & Lucier, 1981;see Willis, 1982, for a review), but the response of wide dynamic range cells to nonnoxious stimuli is also inhibited. Several recent studies have also demonstrated such inhibitory effects on nonnociceptive units, including primary afferents (Martin, Haber, & Willis, 1979) and units in the spinal dorsal horn (Belcher, Ryall, & Schaffner, 1978;McCreery, Bloedel, & Hames, 1979), the trigeminal nucleus caudalis (Dostrovsky, 1980;Dostrovsky, Shah, & Gray, 1983), and the ventrobasal thalamus (Schieppati & Gritti, 1983).…”

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confidence: 99%

“…Several recent studies have also demonstrated such inhibitory effects on nonnociceptive units, including primary afferents (Martin, Haber, & Willis, 1979) and units in the spinal dorsal horn (Belcher, Ryall, & Schaffner, 1978;McCreery, Bloedel, & Hames, 1979), the trigeminal nucleus caudalis (Dostrovsky, 1980;Dostrovsky, Shah, & Gray, 1983), and the ventrobasal thalamus (Schieppati & Gritti, 1983). Brainstem stimulation appears to be less effective in inhibiting responses to nonnoxious stimuli in either low-threshold cells or wide-dynamicrange cells than in inhibiting responses to noxious stimuli (Gebhart et al, 1983;Liebeskind et al, 1973;Oliveras et al, 1974;Sessle et al, 1981). Willis (1982) concludes that "the inhibition appears to be preferentially directed at the responses to Ao and C fibers and less powerful on the responses to AOI and (3 fibers ...…”

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Tactile discrimination following analgesia-producing brainstem stimulation in the rat

Frommer

1985

Psychobiology

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Female albino rats were trained on a standard tactile discrimination and implanted with subcutaneous heating coils and stimulating electrodes aimed at analgesia-producing sites in brainstem. The effectiveness of brain stem stimulation in producing analgesia was assessed by measuring increase in latency offace wiping elicited by heating the subcutaneous coils about 30 sec after brain stimulation. Stimulation was then introduced 15 sec before or at the start of one of the six daily massed tactile discrimination trials. Errors and response latencies on the test discrimination trials were compared with errors and latencies on the immediately preceding and subsequent trials. Eight rats increased latency of face wiping and had electrodes in dorsal periaqueductal gray (P AG). Their performance on the tactile discrimination was disrupted on trials immediately following stimulation. Four other rats also showed increased face-wiping latencies but had electrodes outside dorsal PAG. Their discrimination performance was less consistently affected by brain stimulation. The remaining seven rats did not show increased face-wiping latencies. Their electrodes were also outside dorsal PAG, and they showed latency increases only when stimulation occurred at the start oftest trials. These data indicate that analgesia-producing brainstem stimulation can affect performance on a tactile discrimination task as well as on the reaction to noxious stimulation.

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Functional properties of neurons in cat trigeminal subnucleus caudalis (medullary dorsal horn). II. Modulation of responses to noxious and nonnoxious stimuli by periaqueductal gray, nucleus raphe magnus, cerebral cortex, and afferent influences, and effect of naloxone.

Cited by 196 publications

References 0 publications

Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study

Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study

Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: An fMRI study

Tactile discrimination following analgesia-producing brainstem stimulation in the rat

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