Functional reconfiguration of cerebellum-cerebral neural loop in schizophrenia following electroconvulsive therapy

Hu, Hao; Jiang, Yuchao; Xia, Mengqing; Tang, Yingying; Zhang, Tianhong; Cui, Huiru; Wang, Junjie; Xu, Li-Hua; Curtin, Adrian; Sheng, Jifang; Cao, Xinyi; Guo, Qian; Jia, Yuping; Li, Chunbo; Wang, Zhen; Luo, Cheng; Wang, Jijun

doi:10.1016/j.pscychresns.2022.111441

Cited by 6 publications

(19 citation statements)

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“…The pallidum (bilateral FuG_A37mv) is a very important core brain region for visual processing of the face and cognitive processing of logical information in SZ patients [ 29 ]. Abnormalities in the nodal efficiency of the syrinx gyrus have also been identified in previous studies [ 14 ]. The occipital cortex may be the neurobiological basis for early visual processing deficits in schizophrenia [ 30 ].…”

Section: Discussionsupporting

confidence: 67%

“…eloc and Cp, although consistently different from the HC group after both ECT1 and ECT8, were shown by t-values to decrease gradually with treatment. hu H et al [ 14 ] found a trend toward decreased Eloc in the SZ group compared with the HC group at baseline; Eloc was elevated in the fMRI network of the SZ group after treatment compared with that before ECT treatment. A study using dynamic time-varying brain functional connectivity based on a graph-theoretic approach found that SZ patients showed decreased clustering coefficients in all temporal states [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the graph theory approach was adopted, in which global properties include global efficiency (Eglo) that measure the ability of a network to transmit information simultaneously, local efficiency (Eloc) that measure the fault tolerance of the network, which represents the communication between the neighbors of the node after a node is deleted, clustering coefficient (Cp) that measure the stability of local connections between network nodes and the ability of the network to resist external interference, normalized clustering coefficient (γ) that represents the ratio of the clustering coefficient of the real network to 100 random networks, shortest path length (Lp) that measure the path length of two nodes in a network with the least number of edges, normalized shortest path length (λ) that represents the ratio of the shortest path length of the real network to 100 random networks, small-word network (σ) that has a relatively small λ and large γ, and node properties including Ne and NLe. Previous studies have found that Ne of the right hypooccipital cortex [ 14 ] and NLe of basal ganglia [ 15 ] were lower in patients with schizophrenia than in healthy controls, but there is no graph theory exploration to explore the mechanism of ECT therapy in schizophrenia. In this study, we analyzed the differences in these attribute values in schizophrenic patients before and after ECT and compared with healthy controls on the basis of fMRI to explore brain functional network patterns in schizophrenic patients.…”

Section: Introductionmentioning

confidence: 99%

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Effects of electroconvulsive therapy on functional brain networks in patients with schizophrenia

Geng,

Zhang,

Dong

et al. 2024

BMC Psychiatry

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Background Schizophrenia is a kind of intractable brain disorder. Electroconvulsive therapy (ECT) has been used to rapidly improve the clinical symptoms of patients with schizophrenia, but the effect of ECT on topological attributes of brain functional network in patients with schizophrenia has not been clear. The purpose of this study was to investigate the brain functional network mechanism of ECT against schizophrenia. Methods Thirty-one patients with schizophrenia and fifty healthy controls matching age, gender, and years of education were included. All participants underwent general data collection and magnetic resonance imaging scanning before ECT, and clinical symptoms were assessed using the Positive And Negative Syndrome Scale (PANSS). MRI and clinical symptoms were collected again after the first and eighth ECT application. The functional brain network was constructed on the basis of magnetic resonance imaging, and the global and node topological properties were analyzed. Repeated measure variance analysis was used to explore the changes of the topological attribute values and clinical symptom scores before and after ECT, and Bonferroni post hoc analysis was performed. The independent sample t-test was used to compare the differences in the topological attribute values between patients and healthy controls at three time points before and after ECT. Partial correlation analysis was performed for topological attribute values and clinical symptom scores of abnormal brain regions in the patient groups and their changes during ECT. A general linear regression model was used to predict the outcome after the final eighth ECT using the patient's response to the first ECT. Results (1) One ECT can restore the gamma(γ), lamuda(λ), sigma(σ), nodal global efficiency (Ne) of right insular gyrus ventral agranular insula (INS_R_vIa) and nodal local efficiency (NLe) of bilateral fusiform gyrus medioventral area37 (FuG_A37mv). Eight ECT can also restore the NLe of cortex rostral lingual gyrus (MVOcC _R_rLinG). Eight ECT did not improve the Ne of right superior parietal lobule rostral area 7 (SPL_R_A7r) and NLe of left superior frontal gyrus medial area 6 (SFG_L_A6m). (2) Even after only the first use of ECT, total PANSS scores began to decrease (mean ΔPANSSECT1 was 11.7%; Range, 2%-32.8%), decreased significantly after the eighth application (mean ΔPANSSECT8 was 86.0%; Range,72.5% to 97.9%). Five patients met the response criteria after ECT1 (20% reduction in PANSS total score), and all patients met the response criteria after ECT8. (3) Linear regression analysis showed that ΔPANSSECT1 was a significant predictor of ΔPANSSECT8 (F=5.387, P=0.028), and ΔPANSSECT1 explained 15.7% of the variance of ΔPANSSECT8 (R2=0.157). Conclusions ECT was able to normalize γ, λ, σ, Ne of INS_R_vIa, NLe of bilateral FuG_A37mv in SZ patients after the first treatment, and NLe of MVOcC_R_rLinG after the eighth ECT. ECT significantly alleviates psychotic symptoms in patients with SZ, and its efficacy after eight sessions can be predicted by the patient's response to the first session of ECT.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of electroconvulsive therapy on functional brain networks in patients with schizophrenia

Geng,

Zhang,

Dong

et al. 2024

BMC Psychiatry

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“…Cerebellum as a pivotal hub extensively connected with cortical regions [ 44 , 45 ]. Altered connectivity patterns between cerebellum and cerebral cortices could involve in pathogenesis of schizophrenia [ 27 , 46 , 47 , 48 ]. In our study, both SCZ-nMetS and SCZ-MetS showed significantly abnormal cerebello-cortical FC in cognitive module, including increased FC with regions in DAN, SMN, DMN, SVAN, VN and reduced FC in DMN, DAN.…”

Section: Discussionmentioning

confidence: 99%

“…According to our previous study [ 22 ], reduced grey matter in cerebellum acted as potential structural foundation of the functional disconnection. After the antipsychotics-assisted physical therapy, including transcranial magnetic stimulation and modified electroconvulsive therapy, restoration of network connectivity in cerebello-cortical circuit corresponded to amelioration of psychiatric symptoms of schizophrenia [ 26 , 27 ]. In the present study, we proposed that cerebello-cortical dysconnectivity as a persistent endophenotype of chronic patients with schizophrenia could participate in regulating the symptoms of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome

Zhou

Liu

et al. 2023

Life

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Components of metabolic syndrome might be predictors of the therapeutic outcome of psychiatric symptom in schizophrenia, whereas clinical results are inconsistent and an intrinsic therapeutic link between weaker psychiatric symptoms and emergent metabolic syndrome remains unclear. This study aims to reveal the relationship and illustrate potential mechanism by exploring the alteration of cerebellar functional connectivity (FC) in schizophrenia patients with comorbidity metabolic syndrome. Thirty-six schizophrenia patients with comorbidity of metabolic syndrome (SCZ-MetS), 45 schizophrenia patients without metabolic syndrome (SCZ-nMetS) and 39 healthy controls (HC) were recruited in this study. We constructed FC map of cerebello-cortical circuit and used moderation effect analysis to reveal complicated relationship among FC, psychiatric symptom and metabolic disturbance. Components of metabolic syndrome were significantly correlated with positive symptom score and negative symptom score. Importantly, the dysconnectivity between cognitive module of cerebellum and left middle frontal gyrus in SCZ-nMetS was recuperative increased in SCZ-MetS, and was significantly correlated with general symptom score. Finally, we observed significant moderation effect of body mass index on this correlation. The present findings further supported the potential relationship between emergence of metabolic syndrome and weaker psychiatric symptom, and provided neuroimaging evidence. The mechanism of intrinsic therapeutic link involved functional change of cerebello-cortical circuit.

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Network integration and segregation changes in schizophrenia: impact of electroconvulsive therapy

Ding,

Zhang,

Liu

et al. 2024

BMC Psychiatry

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Functional reconfiguration of cerebellum-cerebral neural loop in schizophrenia following electroconvulsive therapy

Cited by 6 publications

References 61 publications

Effects of electroconvulsive therapy on functional brain networks in patients with schizophrenia

Effects of electroconvulsive therapy on functional brain networks in patients with schizophrenia

Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome

Network integration and segregation changes in schizophrenia: impact of electroconvulsive therapy

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