2021
DOI: 10.1016/j.biomaterials.2021.120925
|View full text |Cite
|
Sign up to set email alerts
|

Functional recovery by colon organoid transplantation in a mouse model of radiation proctitis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
18
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 26 publications
(18 citation statements)
references
References 40 publications
0
18
0
Order By: Relevance
“…In particular, radiation treatment for malignant disorders of pelvic organs induces mucosal damage and progresses to refractory ulcers of the rectum with bleeding. A recent study reported the reconstitution and functional recovery of epithelial structure and integrity by localized transplantation of colon organoids with fibrin glue in a mouse model of radiation-induced proctitis [32].…”
Section: Pdo For Regenerative Medicinementioning
confidence: 99%
“…In particular, radiation treatment for malignant disorders of pelvic organs induces mucosal damage and progresses to refractory ulcers of the rectum with bleeding. A recent study reported the reconstitution and functional recovery of epithelial structure and integrity by localized transplantation of colon organoids with fibrin glue in a mouse model of radiation-induced proctitis [32].…”
Section: Pdo For Regenerative Medicinementioning
confidence: 99%
“…A crypt is an area where ISCs and progeny cells proliferate, and a villus is an area where various functional cells differentiate ( Iftekhar and Sigal, 2021 ; Manco et al, 2021 ). The crypt base is composed of LGR5+ crypt-based columnar (CBC) cells and B-cell-specific Moloney murine leukemia virus Insertion Site 1 (Bmi 1) silent ISCs at the +4 position ( Jee et al, 2021 ; Islam et al, 2022 ). Studies have shown that LGR5+ (LGR5-labeled ISCs) are generally in an active mitotic state and drive permanent intestinal epithelial cell renewal.…”
Section: Introductionmentioning
confidence: 99%
“…The human LGR5 gene has been mapped to chromosome 12q22-23 and shown to have a full-length cDNA sequence consisting of 4208 bp, including 22 exons and 21 introns. Transcription of the cDNA produces eight different mRNAs, five of which are generated through alternative splicing ( Jee et al, 2021 ). The open reading frame encodes a polypeptide chain consisting of 907 amino acid residues, including 21 signal peptides, 540 outer functional regions, 263 transmembrane regions, and 83 C-terminal tail regions.…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations