Functional Recovery of Rabbit Maxillary Sinus Mucosa in Two Different Experimental Injury Models

Kim, Yong Min; Lee, Chul Hee; Won, Tae‐Bin; Kim, Si Whan; Kim, Jeong‐Whun; Rhee, Chae‐Seo; Min, Yang‐Gi

doi:10.1097/mlg.0b013e31815bf2f3

Cited by 10 publications

(11 citation statements)

References 19 publications

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“…In the present study, patients showing intraoperative evidence of sinus membrane perforation during elevation are excluded from the analysis. Experimental research indicates that morphologic regeneration of the maxillary sinus membrane after injury occurs within 12 weeks, but full functional recovery of mucociliary activity may take significantly longer 30 . While resorbable membranes can be used to repair iatrogenic perforations in 95% of cases, 31 defect healing is likely to result in scar tissue formation and significant impairment of mucociliary activity.…”

Section: Discussionmentioning

confidence: 99%

“…Mucociliary clearance is the main factor in preserving sinus physiology and requires both normal ciliary structure and regular ciliary function 30 . While the number of cilia may be normal, defective ciliary function may still lead to impaired mucociliary transport 17 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the degree of variation in the beat direction of individual cilia, i.e., ciliary wave disorder (CWD), must be considered. Similar to low CBF, high values of CWD can lead to impaired mucociliary clearance 30 . Endoscopic methods to quantify rates of mucociliary clearance involve the saccharine time test, the India ink test, and radioisotopic testing, 33,34 but these evaluations, to the best of our knowledge, have never been performed in the grafted maxillary sinus to date.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Maxillary Sinus Floor Augmentation on Sinus Membrane Thickness in Computed Tomography

Pommer

Dvorak

Jesch

et al. 2012

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Maxillary Sinus Floor Augmentation on Sinus Membrane Thickness in Computed Tomography

Pommer

Dvorak

Jesch

et al. 2012

Journal of Periodontology

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“…Morphologic regeneration of the injured mucosa does not guarantee a full functional recovery. 32 Furthermore, scanning electron microscopy may still show signs of insufficient recovery in the form of prominent ciliary loss and disorientation. 32 Supportive studies are needed incorporating functional recovery of the regenerated mucosa.…”

Section: Discussionmentioning

confidence: 99%

Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

Choi

Cho

Choi

et al. 2017

World j. otorhinolaryngol.-head neck surg.

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ObjectiveThe aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions.MethodsA 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks.ResultsThe average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups.ConclusionThe regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets.

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“…Due to the adaptation of TRPM8 to cold stimuli (32,33), cold air cannot evoke a continuous cascade of MUC5AC secretion (20). Moreover, the cilia can undergo morphological regeneration and functional restoration following a mechanical injury (34,35). Thus, cold air can trigger symptoms; however, it is unlikely to be a causal factor that initiates respiratory diseases (1).…”

Section: Discussionmentioning

confidence: 99%

The pathophysiological mechanisms underlying mucus hypersecretion induced by cold temperatures in cigarette smoke-exposed rats

Zhou

et al. 2013

International Journal of Molecular Medicine

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In a recent study, we demonstrated that transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel that is activated by cold temperatures, is localized in the bronchial epithelium and is upregulated in subjects with chronic obstructive pulmonary disease, which causes them to be more sensitive to cold air. In the present study, we found that exposure to cold temperatures induced ciliary ultrastructural anomalies and mucus accumulation on the epithelial surface. Male Sprague-Dawley rats were exposed to cold temperatures to determine the effects of cold air on ultrastructural changes in cilia and the airway epithelial surface. The rats were also exposed to cigarette smoke and/or cold temperatures to determine the effects of smoke and cold air on TRPM8 expression and the role of cold air in cigarette smoke-induced mucus hypersecretion. Following real-time RT-PCR and western blot analysis, we observed a high expression of TRPM8 mRNA and protein in the bronchial tissue following cigarette smoke inhalation. As shown by ELISA, concurrent cold air enhanced the levels of mucin 5AC (MUC5AC) protein, as well as those of inflammatory factors [tumor necrosis factor (TNF)-α and interleukin (IL)-8] that were induced by cigarette smoke inhalation to a greater extent than stimulation with separate stimuli (cold air and cigarette smoke separately). The results suggest that cold air stimuli are responsible for the ultrastructural abnormalities of bronchial cilia, which contribute to abnormal mucus clearance. In addition, cold air synergistically amplifies cigarette smoke-induced mucus hypersecretion and the production of inflammatory factors through the elevated expression of the TRPM8 channel that is initiated by cigarette smoke inhalation.

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Functional Recovery of Rabbit Maxillary Sinus Mucosa in Two Different Experimental Injury Models

Abstract: Although 12 weeks is enough for morphologic regeneration of the ciliated epithelium after experimental sinusitis in rabbit maxillary sinuses, it does not appear long enough for full functional recovery. Restoration of CBFs does not equate to concurrent CWD restoration.

Cited by 10 publications

References 19 publications

Effect of Maxillary Sinus Floor Augmentation on Sinus Membrane Thickness in Computed Tomography

Effect of Maxillary Sinus Floor Augmentation on Sinus Membrane Thickness in Computed Tomography

Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

The pathophysiological mechanisms underlying mucus hypersecretion induced by cold temperatures in cigarette smoke-exposed rats

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