Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment

Zhang, Yanfei; Qiu, Zhidong; Qiu, Ye; Su, Ting; Qu, Peng; Jia, Ailing

doi:10.1177/1534735419886655

Cited by 12 publications

(8 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ginsenosides, the main active ingredient of ginseng, have significant anticancer activity by inhibiting cell proliferation, promoting apoptosis, inducing cell cycle arrest of cancer cells, inhibiting tumor angiogenesis, and synergizing with chemo-/radiotherapy [245]. Besides, ginsenosides can activate the body's immunity through different ways to fight against cancer [246]. Some kinds of ginsenosides are undergoing clinical trials [247].…”

Section: Terpenoidsmentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Head and neck cancer is a highly genetic and metabolic heterogeneous collection of malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses, and larynx with five-year survival rates ranging from 12% to 93%. Patients with head and neck cancer typically present with advanced stage III, IVa, or IVb disease and are treated with comprehensive modality including chemotherapy, radiotherapy, and surgery. Despite advancements in treatment modality and technique, noisome recurrence, invasiveness, and resistance as well as posttreatment complications severely influence survival rate and quality of life. Thus, new therapeutic strategies are urgently needed that offer enhanced efficacy with less toxicity. ROS in cancer cells plays a vital role in regulating cell death, DNA repair, stemness maintenance, metabolic reprogramming, and tumor microenvironment, all of which have been implicated in resistance to chemo-/radiotherapy of head and neck cancer. Adjusting ROS generation and elimination to reverse the resistance of cancer cells without impairing normal cells show great hope in improving the therapeutic efficacy of chemo-/radiotherapy of head and neck cancer. In the current review, we discuss the pivotal and targetable redox-regulating system including superoxide dismutases (SODs), tripeptide glutathione (GSH), thioredoxin (Trxs), peroxiredoxins (PRXs), nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/keap1), and mitochondria electron transporter chain (ETC) complexes and their roles in regulating ROS levels and their clinical significance implicated in chemo-/radiotherapy of head and neck cancer. We also summarize several old drugs (referred to as the non-anti-cancer drugs used in other diseases for a long time) and small molecular compounds as well as natural herbs which effectively modulate cellular ROS of head and neck cancer to synergize the efficacy of conventional chemo-/radiotherapy. Emerging interdisciplinary techniques including photodynamic, nanoparticle system, and Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy are promising measures to broaden the potency of ROS modulation for the benefit of chemo-/radiotherapy in head and neck cancer.

show abstract

Section: Terpenoidsmentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Our previous data demonstrated that some of Ginsenosides isolated from Panax ginseng C. A. Mey. were able to convert TAM polarization from M2-like to M1-like to attenuate tumor metastasis ( Zhang Y. et al, 2019 ). Recently, Panax ginseng C. A. Mey.-derived nanoparticles (PGDN) were also found to have similar regulatory roles on TAMs in melanoma.…”

Section: The Impact Of Chm and Their Active Ingredients On Timps In Tmentioning

confidence: 99%

“…Our recent report has shown that Ginsenosides, as the functional contents of ginseng, enhance the antigen presentation function of DCs within the TME. Ginsenosides activate the activity of DCs and promote adaptive immune responses to exert anticancer effects in tumor-bearing mice ( Zhang Y. et al, 2019 ). Both the purified glycyrrhizin (GL) and Carthamus tinctorius L. (CT) extract stimulate DC maturation to bolster antitumor activity.…”

Section: The Impact Of Chm and Their Active Ingredients On Timps In Tmentioning

confidence: 99%

Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment

Liu

Wang

Qiu

et al. 2021

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

The tumor microenvironment (TME) is composed of tumor cells, blood/lymphatic vessels, the tumor stroma, and tumor-infiltrating myeloid precursors (TIMPs) as a sophisticated pathological system to provide the survival environment for tumor cells and facilitate tumor metastasis. In TME, TIMPs, mainly including tumor-associated macrophage (TAM), tumor-associated dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs), play important roles in repressing the antitumor activity of T cell or other immune cells. Therefore, targeting those cells would be one novel efficient method to retard cancer progression. Numerous studies have shown that traditional Chinese medicine (TCM) has made extensive research in tumor immunotherapy. In the review, we demonstrate that Chinese herbal medicine (CHM) and its components induce tumor cell apoptosis, directly inhibiting tumor growth and invasion. Further, we discuss that TCM regulates TME to promote effective antitumor immune response, downregulates the numbers and function of TAMs/MDSCs, and enhances the antigen presentation ability of mature DCs. We also review the therapeutic effects of TCM herbs and their ingredients on TIMPs in TME and systemically analyze the regulatory mechanisms of TCM on those cells to have a deeper understanding of TCM in tumor immunotherapy. Those investigations on TCM may provide novel ideas for cancer treatment.

show abstract

“…Tumour‐immune cells interaction is a significant territory of research in regard to prognosis in CRC. Cancer accelerating inflammation orchestrates a strong immune cell response and the tumour microenvironment (TME) are arising as crucial obstacles to the development of effective therapies 6,7 . Specifically, tumour‐associated macrophages (TAMs) are dominating immune cells in the TME and have been implicated in neoplastic progression, survival and metastatic dissemination in various solid tumours 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value and predictive biomarkers of phenotypes of tumour‐associated macrophages in colorectal cancer

Sun

Yang

et al. 2022

Scand J Immunol

View full text Add to dashboard Cite

Background The roles of different subtypes of tumour‐associated macrophages (TAMs) in predicting the prognosis of colorectal cancer (CRC) remain controversial. In this study, different subtypes of TAMs were investigated as prognostic and predictive biomarkers for CRC. Methods Expressions of CD68, CD86 and CD163 were investigated by immunohistochemistry (IHC) and immunofluorescence (IF), and the correlation between the expression of CD86 and CD163 was calculated in colorectal cancer tissues from 64 CRC patients. Results The results showed that high expressions of CD86+ and CD68+CD86+ TAMs as well as low expression of CD163+ and CD68+CD163+ TAMs were significantly associated with favourable overall survival (OS). The level of CD86 protein expression showed a negative correlation with CD163 protein expression. In addition, CD86 protein expression remarkably negatively correlated with tumour differentiation and tumour node metastasis (TNM) stage, while CD163 protein expression significantly positively correlated with tumour differentiation and tumour size. As an independent risk factor, high expression of CD86 TAMs had prominently favourable prognostic efficacy, while high expression of CD68+CD163+ TAMs had significantly poor prognostic efficacy. Conclusions These results indicate that CD86+ and CD68+CD163+ TAMs as prognostic and predictive biomarkers for CRC.

show abstract

Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment

Cited by 12 publications

References 72 publications

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment

Prognostic value and predictive biomarkers of phenotypes of tumour‐associated macrophages in colorectal cancer

Contact Info

Product

Resources

About