Functional relevance of three proopiomelanocortin (POMC) genes in darkening camouflage, blind-side hypermelanosis, and appetite of Paralichthys olivaceus

Dh, Kang; Kim, Hyo-Chan

doi:10.1016/j.cbpb.2014.09.002

Cited by 19 publications

(10 citation statements)

References 73 publications

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“…Interestingly, three POMC paralogs (named POMCa1, POMCa2, and POMCb) have been identified, similar to previous reports in other ray-finned fish, such as barifin flounder, cichlid fish, and sea bream [22,23,34,35]. As in other teleosts, three tilapia POMC precursors are likely capable of producing three bioactive peptides, namely α-MSH, β-MSH, and ACTH; however, they cannot produce 7-MSH present in lungfish, paddlefish, sturgeons, and tetrapods [36][37][38][39].…”

Section: Identification Of Mc4r Signaling System In Nile Tilapiasupporting

confidence: 84%

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Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia

Liu

Deng

Zhang

et al. 2020

IJMS

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The melanocortin receptor 4 (MC4R) signaling system consists of MC4R, MC4R ligands [melanocyte-stimulating hormone (MSH), adrenocorticotropin (ACTH), agouti-related protein (AgRP)], and melanocortin-2 receptor accessory protein 2 (MRAP2), and it has been proposed to play important roles in feeding and growth in vertebrates. However, the expression and functionality of this system have not been fully characterized in teleosts. Here, we cloned tilapia MC4R, MRAP2b, AgRPs (AgRP, AgRP2), and POMCs (POMCa1, POMCb) genes and characterized the interaction of tilapia MC4R with MRAP2b, AgRP, α-MSH, and ACTH in vitro. The results indicate the following. (1) Tilapia MC4R, MRAP2b, AgRPs, and POMCs share high amino acid identity with their mammalian counterparts. (2) Tilapia MRAP2b could interact with MC4R expressed in CHO cells, as demonstrated by Co-IP assay, and thus decrease MC4R constitutive activity and enhance its sensitivity to ACTH1-40. (3) As in mammals, AgRP can function as an inverse agonist and antagonist of MC4R, either in the presence or absence of MRAP2b. These data, together with the co-expression of MC4R, MRAP2b, AgRPs, and POMCs in tilapia hypothalamus, suggest that as in mammals, ACTH/α-MSH, AgRP, and MRAP2 can interact with MC4R to control energy balance and thus play conserved roles in the feeding and growth of teleosts.

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Section: Identification Of Mc4r Signaling System In Nile Tilapiasupporting

confidence: 84%

“…Of particular interest to note is that POMCb is highly expressed in the skin. Similarly, POMCb is also expressed in the skin of barfin flounder [35,48]. In addition, α-MSH/ACTH immunoreactivity was detected in the germinal layer of African lungfish skin epidermis [49].…”

Section: Tissue Expression Of Mc4r Signaling System In Tilapiamentioning

confidence: 93%

Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia

Liu

Deng

Zhang

et al. 2020

IJMS

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“…In both olive (Kang and Kim, 2015) and Barfin flounder (Takahashi et al, 2005) (Pleuronectiformes), pituitary POMC-C (isoforms 1, 2, and 3) mRNAs are not affected by fasting, suggesting pituitary POMC might not directly related to appetite regulation. However, in fasted halibut larvae, whole brain POMC-C mRNA expression is higher in unfed fish 30 min after re-feeding compared to continuously fed fish (Gomes et al, 2015), suggesting a short-term regulation of appetite.…”

Section: Hormones Involved In Food Intakementioning

confidence: 99%

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

2016

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Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

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“…However, the functions of the fish pomc subtypes remain largely unexplored. In rainbow trout, fasting induces increased expression levels of both hypothalamic pomca1 and pomcb (121), whereas in olive flounder ( Paralichthys olivaceus ), pomc2 but not pomc1 and pomc3 mRNA levels increase with fasting (122), suggesting a form-specific response of pomc in some species.…”

Section: Central Controlmentioning

confidence: 99%

Appetite-Controlling Endocrine Systems in Teleosts

et al. 2017

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Mammalian studies have shaped our understanding of the endocrine control of appetite and body weight in vertebrates and provided the basic vertebrate model that involves central (brain) and peripheral signaling pathways as well as environmental cues. The hypothalamus has a crucial function in the control of food intake, but other parts of the brain are also involved. The description of a range of key neuropeptides and hormones as well as more details of their specific roles in appetite control continues to be in progress. Endocrine signals are based on hormones that can be divided into two groups: those that induce (orexigenic), and those that inhibit (anorexigenic) appetite and food consumption. Peripheral signals originate in the gastrointestinal tract, liver, adipose tissue, and other tissues and reach the hypothalamus through both endocrine and neuroendocrine actions. While many mammalian-like endocrine appetite-controlling networks and mechanisms have been described for some key model teleosts, mainly zebrafish and goldfish, very little knowledge exists on these systems in fishes as a group. Fishes represent over 30,000 species, and there is a large variability in their ecological niches and habitats as well as life history adaptations, transitions between life stages and feeding behaviors. In the context of food intake and appetite control, common adaptations to extended periods of starvation or periods of abundant food availability are of particular interest. This review summarizes the recent findings on endocrine appetite-controlling systems in fish, highlights their impact on growth and survival, and discusses the perspectives in this research field to shed light on the intriguing adaptations that exist in fish and their underlying mechanisms.

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Functional relevance of three proopiomelanocortin (POMC) genes in darkening camouflage, blind-side hypermelanosis, and appetite of Paralichthys olivaceus

Cited by 19 publications

References 73 publications

Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia

Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

Appetite-Controlling Endocrine Systems in Teleosts

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