Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents

Li, Wenjing; Li, Jianhong; Wang, Jieqiong; Zhou, Peng; Wang, Zhenchang; Xian, Junfang; He, Huiguang

doi:10.1155/2016/9849087

Cited by 20 publications

(32 citation statements)

References 40 publications

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“…Increased resting-state functional connections were reported between the right superior parietal gyrus (rSPG) and the right insula, and between the middle temporal gyrus and the posterior cingulate gyrus (2016). In the same study, Li et al (2016) also reported an altered arrangement of highly interconnected functional hubs.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 73%

Early deafness leads to re-shaping of functional connectivity beyond the auditory cortex

Bonna

Finc

Zimmermann

et al. 2020

Brain Imaging and Behavior

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Early sensory deprivation, such as deafness, shapes brain development in multiple ways. Deprived auditory areas become engaged in the processing of stimuli from the remaining modalities and in high-level cognitive tasks. Yet, structural and functional changes were also observed in non-deprived brain areas, which may suggest the whole-brain network changes in deaf individuals. To explore this possibility, we compared the resting-state functional network organization of the brain in early deaf adults and hearing controls and examined global network segregation and integration. Relative to hearing controls, deaf adults exhibited decreased network segregation and an altered modular structure. In the deaf, regions of the salience network were coupled with the fronto-parietal network, while in the hearing controls, they were coupled with other large-scale networks. Deaf adults showed weaker connections between auditory and somatomotor regions, stronger coupling between the fronto-parietal network and several other large-scale networks (visual, memory, cingulo-opercular and somatomotor), and an enlargement of the default mode network. Our findings suggest that brain plasticity in deaf adults is not limited to changes in the auditory cortex but additionally alters the coupling between other large-scale networks and the development of functional brain modules. These widespread functional connectivity changes may provide a mechanism for the superior behavioral performance of the deaf in visual and attentional tasks.

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Section: Electronic Supplementary Materialsmentioning

confidence: 73%

Early deafness leads to re-shaping of functional connectivity beyond the auditory cortex

Bonna

Finc

Zimmermann

et al. 2020

Brain Imaging and Behavior

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“…However, to the best of our knowledge, no direct mapping of the tonotopic, or topographic, organization was conducted in the CI-naïve congenitally deaf human auditory cortex, let alone in its association regions, without any auditory sensory experience. On the other hand, there is evidence for plasticity in this population: there are clear changes in white matter and gray matter volumes and correlation in early auditory cortex 93 94 95 , and changes in functional connectivity of the auditory cortex 9 96 97 . Such changes tend to emphasize cross-modal compensatory plasticity, especially with regard to language.…”

Section: Discussionmentioning

confidence: 99%

Topographical functional connectivity patterns exist in the congenitally, prelingually deaf

Striem-Amit

Almeida

Belledonne

et al. 2016

Sci Rep

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Congenital deafness causes large changes in the auditory cortex structure and function, such that without early childhood cochlear-implant, profoundly deaf children do not develop intact, high-level, auditory functions. But how is auditory cortex organization affected by congenital, prelingual, and long standing deafness? Does the large-scale topographical organization of the auditory cortex develop in people deaf from birth? And is it retained despite cross-modal plasticity? We identified, using fMRI, topographic tonotopy-based functional connectivity (FC) structure in humans in the core auditory cortex, its extending tonotopic gradients in the belt and even beyond that. These regions show similar FC structure in the congenitally deaf throughout the auditory cortex, including in the language areas. The topographic FC pattern can be identified reliably in the vast majority of the deaf, at the single subject level, despite the absence of hearing-aid use and poor oral language skills. These findings suggest that large-scale tonotopic-based FC does not require sensory experience to develop, and is retained despite life-long auditory deprivation and cross-modal plasticity. Furthermore, as the topographic FC is retained to varying degrees among the deaf subjects, it may serve to predict the potential for auditory rehabilitation using cochlear implants in individual subjects.

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“…In the context of ERPs, calculating partial directed coherence (PDC) based on such time-variant multivariate autoregressive models and measures as centrality or modularity have emerged as useful tools for assessing connectivity between different brain locations ( Schelter et al, 2006 ; Keller et al, 2014 ; Rodrigues and Baccalá, 2015 ). Recently, graph theory-based methods have been used to explore the cortical reorganization of functional networks in prelingual deaf adolescents ( Li et al, 2016 ). Indeed, ERPs and graph analyses are complementary, not mutually exclusive techniques (eg., Mutlu et al, 2012 ) that can contribute to a better understanding of how profoundly deaf individuals learn to discriminate sound using a novel sensory pathway.…”

Section: Introductionmentioning

confidence: 99%

Vibrotactile Discrimination Training Affects Brain Connectivity in Profoundly Deaf Individuals

González-Garrido

Ruiz-Stovel

Gómez-Velázquez

et al. 2017

Front. Hum. Neurosci.

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Early auditory deprivation has serious neurodevelopmental and cognitive repercussions largely derived from impoverished and delayed language acquisition. These conditions may be associated with early changes in brain connectivity. Vibrotactile stimulation is a sensory substitution method that allows perception and discrimination of sound, and even speech. To clarify the efficacy of this approach, a vibrotactile oddball task with 700 and 900 Hz pure-tones as stimuli [counterbalanced as target (T: 20% of the total) and non-target (NT: 80%)] with simultaneous EEG recording was performed by 14 profoundly deaf and 14 normal-hearing (NH) subjects, before and after a short training period (five 1-h sessions; in 2.5–3 weeks). A small device worn on the right index finger delivered sound-wave stimuli. The training included discrimination of pure tone frequency and duration, and more complex natural sounds. A significant P300 amplitude increase and behavioral improvement was observed in both deaf and normal subjects, with no between group differences. However, a P3 with larger scalp distribution over parietal cortical areas and lateralized to the right was observed in the profoundly deaf. A graph theory analysis showed that brief training significantly increased fronto-central brain connectivity in deaf subjects, but not in NH subjects. Together, ERP tools and graph methods depicted the different functional brain dynamic in deaf and NH individuals, underlying the temporary engagement of the cognitive resources demanded by the task. Our findings showed that the index-fingertip somatosensory mechanoreceptors can discriminate sounds. Further studies are necessary to clarify brain connectivity dynamics associated with the performance of vibrotactile language-related discrimination tasks and the effect of lengthier training programs.

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Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents

Cited by 20 publications

References 40 publications

Early deafness leads to re-shaping of functional connectivity beyond the auditory cortex

Early deafness leads to re-shaping of functional connectivity beyond the auditory cortex

Topographical functional connectivity patterns exist in the congenitally, prelingually deaf

Vibrotactile Discrimination Training Affects Brain Connectivity in Profoundly Deaf Individuals

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