Functional roles of CREB as a positive regulator in the formation and enhancement of memory

Memory formation and retention are affected in adult miR-132/212 knockout mice

“…Compensatory or regulatory feedback mechanisms could equally explain the effects on BDNF and CREB, which function a priori upstream of miR-132/212. Normally, increased phosphorylation of CREB (gain-of-function) is associated with improved spatial learning (reviewed in [44]). Similar positive effects on memory have been reported in the absence of MeCP2 [45].…”

Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats

“…CREBmediated transcription has been described as a molecular switch required for learning and memory. The phosphorylation of CREB induces transcriptional activation which leads to gene products that play a key role in synaptic plasticity and cognitive function (Kida and Serita 2014). CREB also regulates the expression of many genes that have been implicated in depression and antidepressant response (Tardito et al 2006;Gass and Riva 2007).…”

“…CREB is involved in the formation and retention of memory in several species (Kida and Serita 2014). CREBmediated transcription has been described as a molecular switch required for learning and memory.…”

PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice

“…A recent study has shown that genetic manipulation of the eIF2␣ kinases, PERK and GCN2, in APP-PS1 AD model restores synaptic deficits and improves memory impairment by reducing eIF2␣ hyperphosphorylation and ATF4 expression . ATF4 links translation regulation with cAMP response element-binding protein (CREB) family-dependent transcription, which has been studied extensively for its essential role in normal and pathological learning and memory processes (Silva et al, 1998;Satoh et al, 2009;Kida and Serita, 2014). Recent work revealed both translational and transcriptional active roles of ATF4 in the development of AD pathology (Baleriola et al, 2014).…”