Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review

Ilieva, Mirolyuba; Uchida, Shizuka

doi:10.21037/atm-22-1074

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…This metabolic shit is known as the "Warburg effect" (Warburg 1956) and can be visualized on figure 2C. As posited by the altered glycolysis in ASD stem cells described above, a reduced amount of ATP produced by this pathway was observed, a finding consistent with a study showing that cerebral organoids derived for ASD paQents exhibit a predominance of glycolysis over OXPHOS and reduced ATP producQon (Ilieva and Uchida 2022). Nonetheless, it should be noted that such findings depend on the context and, possibly, the cell type.…”

Section: A Lower Abundance Of Atpsupporting

confidence: 78%

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

Féron,

Caillol,

Fourel

et al. 2024

Preprint

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In two previous studies, based on human olfactory ecto-mesenchymal stem cells (OEMSC) of 11 patients with autism spectrum disorders (ASD) and 11 healthy individuals, we demonstrated that the lower abundance of the enzyme MOCOS (MOlybdenum COfactor Sulfurase) and its associated lower expression of the long non-coding RNA, COSMOC, induces neurotransmission and synaptic defects as well as an exacerbated oxidative stress sensitivity. To move a step further, we assessed whether these defects were associated to a disturbed mitochondrial homeostasis. For that purpose, we used cellular and molecular techniques to quantify mitochondrial metabolism and biogenesis, ATP production and cell respiration in OEMSCs from the 8 ASD patients of the cohort that display the most severe symptoms. We show here that OEMSCs from ASD patients, when compared to control individuals, display i) a reduced expression/abundance of glycolysis-associated transcripts and metabolites, ii) an overall reduced ATP, mainly due to the impaired glycolysis, iii) a reduced basal cell respiration and iv) a modified mitochondrial network. These results are in accordance with some of our previously published data and may explain some of the symptoms (stress, overarousal, seizures, increased or decreased muscle tone, fatigue) observed in autism spectrum disorders.

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Section: A Lower Abundance Of Atpsupporting

confidence: 78%

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

Féron,

Caillol,

Fourel

et al. 2024

Preprint

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show abstract

“…Considering the importance of RNA modifications in regulating gene expression, it is not surprising that RNA modifications are critically involved in normal development and pathological processes [ 24 ]. Studies have shown that RNA m6A modification regulators play important roles in the developmental processes of the brain, heart, skeletal muscle, and immune cell maturation [ 28 , 29 , 30 , 31 ]. For example, it has been found that nearly 25% of RNA transcripts in the healthy mouse and human heart display m6A modification [ 32 ], suggesting a critical role of RNA m6A modification in normal heart function.…”

Section: Epitranscriptomicsmentioning

confidence: 99%

The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis

Yang

Wang

2022

IJMS

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Metals are common toxic environmental pollutants. Acute or chronic exposure to metal pollutants causes severe adverse health effects in animals and humans, such as developmental retardation, abnormal metabolism, and disorders of cardiovascular, neurologic, respiratory, reproductive, and urologic systems. Moreover, several metals (arsenic, cadmium, chromium, and nickel) are classified as potent Group I carcinogens and cause various types of cancer in humans. Although the toxicity and carcinogenicity of metal pollutants are well recognized, the underlying mechanisms have not been clearly defined. The epitranscriptome includes all kinds of chemical modifications of all forms of RNA molecules inside a cell. Recent progresses in demonstrating the reversible pattern of RNA modifications and their roles in physiology and pathogenesis represent a breakthrough in the field of RNA biology and function study. The epitranscriptomic study is now an exciting emerging field in toxicology research. While few studies have been conducted so far to determine the epitranscriptomic effects of metal pollutants, they offer novel insights for understanding the mechanisms of metal toxicity and carcinogenesis. The goal of this review is to discuss recent studies on the epitranscriptomic effects of metals and propose some thoughts for future studies in the field.

show abstract

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

Féron,

Caillol,

Fourel

et al. 2024

Preprint

View full text Add to dashboard Cite

In two previous studies, based on human olfactory ecto-mesenchymal stem cells (OE-MSC) of 11 patients with autism spectrum disorders (ASD) and 11 healthy individuals, we demonstrated that the lower abundance of the enzyme MOCOS (MOlybdenum COfactor Sulfurase) and its associated lower expression of the long non-coding RNA, COSMOC, induces neurotransmission and synaptic defects as well as an exacerbated oxidative stress sensitivity. To move a step further, we assessed whether these defects were associated to a disturbed mitochondrial homeostasis. For that purpose, we used cellular and molecular techniques to quantitfy mitochondrial metabolism and biogenesis, ATP production and cell respiration in OE-MSCs from the 8 ASD patients of the cohort that display the most severe symptoms. We show here that OE-MSCs from ASD patients, when compared to control individuals, display i) a reduced expression/abundance of glycolysis-associated transcripts and metabolites, ii) an overall reduced ATP, mainly due to the impaired glycolysis, iii) a reduced basal cell respiration and iv) a modified mitochondrial network. These results are in accordance with some of our previously published data and may explain some of the symptoms – stress, overarousal, seizures, increased or decreased muscle tone, fatigue - observed in autism spectrum disorders.

show abstract

Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review

Cited by 3 publications

References 63 publications

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis

Autism spectrum disorders: an impaired glycolysis induces an ATP deficiency and a reduced cell respiration

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