Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

Salahudeen, Ameen A.; Seoane, Jose A.; Yuki, Kanako; Mah, Amanda T.; Smith, Amber R.; Kolahi, Kevin; De la O, Sean M.; Hart, Daniel J.; Ding, Jie; Ma, Zhicheng; Barkal, Sammy A.; Shukla, Navika D.; Zhang, Chuck H.; Cantrell, Michael A.; Batish, Arpit; Usui, Tatsuya; Root, David E.; Hahn, William C.; Curtis, Christina; Kuo, Calvin J.

doi:10.1016/j.celrep.2023.113355

Cell Reports

2023

DOI: 10.1016/j.celrep.2023.113355

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Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

Ameen A. Salahudeen,

Jose A. Seoane,

Kanako Yuki

et al.

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2024

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Cited by 2 publications

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Organoids in the oral and maxillofacial region: present and future

Wu,

Li,

Liu

et al. 2024

Int J Oral Sci

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The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatomically vulnerable to the pathogenic factors of trauma, inflammation, and cancer. The studies of this intricate entity have been long-termly challenged by a lack of versatile preclinical models. Recently, the advancements in the organoid industry have provided novel strategies to break through this dilemma. Here, we summarize the existing biological and engineering approaches that were employed to generate oral and maxillofacial organoids. Then, we detail the use of modified co-culture methods, such as cell cluster co-inoculation and air-liquid interface culture technology to reconstitute the vascular network and immune microenvironment in assembled organoids. We further retrospect the existing oral and maxillofacial assembled organoids and their potential to recapitulate the homeostasis in parental tissues such as tooth, salivary gland, and mucosa. Finally, we discuss how the next-generation organoids may benefit to regenerative and precision medicine for treatment of oral-maxillofacial illness.

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Organoids in the oral and maxillofacial region: present and future

Wu,

Li,

Liu

et al. 2024

Int J Oral Sci

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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment

Polak,

Zhang,

Kuo

2024

Nat Rev Cancer

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Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

Cited by 2 publications

References 66 publications

Organoids in the oral and maxillofacial region: present and future

Organoids in the oral and maxillofacial region: present and future

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment

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