Functional selenium modified microgels: temperature-induced phase transitions and network morphology

Tan, Kok H.; Demco, Dan E.; Fechete, Radu; Pich, Andrij

doi:10.1039/c8sm02646g

Cited by 18 publications

(27 citation statements)

References 55 publications

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“…Briefly, the microgels were fabricated in an inverse miniemulsion through free-radical emulsion polymerization. HPMA was the main constituent of the microgels, doubly crosslinked with BMASC [30,31] and MBAA to improve the preservation of functional microgelic systems. To facilitate the surface functionalization, glycidyl methacrylate (GMA) was introduced to the microgel structure.…”

Section: Microgel Synthesis and Coatingmentioning

confidence: 99%

“…An enzyme mimetic non-fouling microgel coating for endogenous NO release was recently developed by this group [29]. The microgels with a highly hydrophilic base are incorporated with diselenide crosslinks [30,31]. While the hydrophilicity provides the protein repellency, the reversible diselenide bridges mimic the enzymatic function of the selenium-bearing glutathion peroxide (GPx) to cleave the S-nitroso bond (S-NO) of S-nitrosoproteins.…”

Section: Introductionmentioning

confidence: 99%

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Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow

et al. 2022

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Background: Clot formation on foreign surfaces of extracorporeal membrane oxygenation systems is a frequent event. Herein, we show an approach that mimics the enzymatic process of endogenous nitric oxide (NO) release on the oxygenator membrane via a biomimetic, non-fouling microgel coating to spatiotemporally inhibit the platelet (PLT) activation and improve antithrombotic properties. This study aims to evaluate the potential of this biomimetic coating towards NO-mediated PLT inhibition and thereby the reduction of clot formation under flow conditions. Methods: Microgel-coated (NOrel) or bare (Control) poly(4-methyl pentene) (PMP) fibers were inserted into a test channel and exposed to a short-term continuous flow of human blood. The analysis included high-resolution PLT count, pooled PLT activation via β-Thromboglobulin (β-TG) and the visualization of remnants and clots on the fibers using scanning electron microscopy (SEM). Results: In the Control group, PLT count was significantly decreased, and β-TG concentration was significantly elevated in comparison to the NOrel group. Macroscopic and microscopic visualization showed dense layers of stable clots on the bare PMP fibers, in contrast to minimal deposition of fibrin networks on the coated fibers. Conclusion: Endogenously NO-releasing microgel coating inhibits the PLT activation and reduces the clot formation on PMP fibers under dynamic flow.

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Section: Microgel Synthesis and Coatingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow

et al. 2022

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“…Selenium was discovered in 1817 by J. Berzelius and J. Gahn, who investigated a reddish brown residue after manufacturing sulfuric acid [52,53]. Selenium belongs to the family of chalcogens, including oxygen, sulfur, tellurium, and polonium and forms several allotropes that interconvert with changes in temperature [54,55].…”

Section: Selenium 21 Selenium Synthesismentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.

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“…[ 1 ] They are widely used for applications in, e.g., drug delivery, cell encapsulation, or separation and purification technologies. [ 2 , 3 , 4 , 5 ] Poly( N ‐isopropylacrylamide) (PNIPAAm) and poly( N ‐vinylcaprolactam) (PVCL) are the two most popular temperature‐responsive polymers used for μgel preparation. [ 5 ] While the use of PNIPAAm is limited in biomedical applications due to its toxicity, [ 6 ] PVCL μgels have been shown to be biocompatible retaining the advantageous temperature‐responsive properties of PNIPAAm.…”

Section: Introductionmentioning

confidence: 99%

Mechanically Resistant Poly(N‐vinylcaprolactam) Microgels with Sacrificial Supramolecular Catechin Hydrogen Bonds

et al. 2022

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Microgels (μgels) swiftly undergo structural and functional degradation when they are exposed to shear forces, which potentially limit their applicability in, e.g., biomedicine and engineering. Here, poly( N ‐vinylcaprolactam) μgels that resist mechanical disruption through supramolecular hydrogen bonds provided by (+)‐catechin hydrate (+C) are synthesized. When +C is added to the microgel structure, an increased resistance against shear force exerted by ultrasonication is observed compared to μgels crosslinked by covalent bonds. While covalently crosslinked μgels degrade already after a few seconds, it is found that μgels having both supramolecular interchain interactions and covalent crosslinks show the highest mechanical durability. By the incorporation of optical force probes, it is found that the covalent bonds of the μgels are not stressed beyond their scission threshold and mechanical energy is dissipated by the force‐induced reversible dissociation of the sacrificial +C bonds for at least 20 min of ultrasonication. Additionally, +C renders the μgels pH‐sensitive and introduces multiresponsivity. The μgels are extensively characterized using Fourier‐transform infrared, Raman and quantitative nuclear magnetic resonance spectroscopy, dynamic light scattering, and cryogenic transmission electron microscopy. These results may serve as blueprint for the preparation of many mechanically durable μgels.

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Functional selenium modified microgels: temperature-induced phase transitions and network morphology

Abstract: Selenium modified microgels were characterized by DSL and 1H NMR using modified Flory–Rehner theory and a two-state model.

Cited by 18 publications

References 55 publications

Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow

Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow

The Effects of Selenium on Bone Health: From Element to Therapeutics

Mechanically Resistant Poly(N‐vinylcaprolactam) Microgels with Sacrificial Supramolecular Catechin Hydrogen Bonds

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