Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy

Zhu, Zhuang; Ren, Wenhao; Li, Shaoming; Gao, Ling; Zhi, Keqian

doi:10.1016/j.phrs.2024.107120

Cited by 2 publications

(2 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autophagy functions as a cellular self-defense mechanism that shields cells from metabolic stress and oxidative damage. Recent studies showed that O-GlcNAcylation exerted varied effects on proteins engaged in distinct phases of autophagy, which affected the overall process of bone remodeling by regulating autophagy in BMSCs, osteoclasts, and osteoblasts [ 13 , 41 ].…”

Section: O-glcnacylation: a Sweet Regulator Of Autophagymentioning

confidence: 99%

“…O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a monosaccharide post-translational modification (PTM), which is implicated in several physiological functions, such as metabolism, signaling, transcription, and translation [ 12 ]. As a crucial sensor of oxidative stress, many proteins involved in the autophagic process have been identified as targets for O-GlcNAcylation [ 13 ]. Only two conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), are involved in O-GlcNAcylation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

Li,

Ren,

Zheng

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding of serine and/or threonine residues, which regulates bone cell homeostasis. Reactive oxygen species (ROS) are increased due to oxidative stress in various pathological contexts related to bone remodeling, such as osteoporosis, arthritis, and bone fracture. Autophagy serves as a scavenger for ROS within bone marrow-derived mesenchymal stem cells, osteoclasts, and osteoblasts. However, oxidative stress-induced autophagy is affected by the metabolic status, leading to unfavorable clinical outcomes. O-GlcNAcylation can regulate the autophagy process both directly and indirectly through oxidative stress-related signaling pathways, ultimately improving bone remodeling. The present interventions for the bone remodeling process often focus on promoting osteogenesis or inhibiting osteoclast absorption, ignoring the effect of PTM on the overall process of bone remodeling. This review explores how O-GlcNAcylation synergizes with autophagy to exert multiple regulatory effects on bone remodeling under oxidative stress stimulation, indicating the application of O-GlcNAcylation as a new molecular target in the field of bone remodeling. Graphical Abstract

show abstract

Section: O-glcnacylation: a Sweet Regulator Of Autophagymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

Li,

Ren,

Zheng

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

O-GlcNAcylation dictates pyroptosis

Lang,

Li,

Zhang

2024

Front. Immunol.

View full text Add to dashboard Cite

O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of pyroptosis, suggesting that enhancing O-GlcNAcylation of GSDMD could be crucial for improving hypoperfusion in sepsis. Additionally, GSDME, another member of the gasdermin family, facilitates macrophage pyroptosis through O-GlcNAcylation induced by high glucose levels in the context of periodontitis. The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-κB. Overall, this review emphasizes the role of O-GlcNAcylation in the pathogenesis of conditions such as sepsis, periodontitis, and osteoarthritis, identifying potential therapeutic targets for managing inflammatory responses through its targeted modulation.

show abstract

Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy

Cited by 2 publications

References 97 publications

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

O-GlcNAcylation dictates pyroptosis

Contact Info

Product

Resources

About