Functional Specialization for Semantic and Phonological Processing in the Left Inferior Prefrontal Cortex

Poldrack, Russell A.; Wagner, Anthony D.; Prull, Matthew W.; Desmond, John E.; Glover, Gary H.; Gabrieli, John D. E.

doi:10.1006/nimg.1999.0441

Cited by 1,324 publications

(992 citation statements)

References 69 publications

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“…Consistent with previous studies reporting activation in response to phonological tasks with heard and written words [Burton et al, 2003;Devlin et al, 2003;Fujimaki et al, 1999;Gold et al, 2005;Gold and Buckner, 2002;McDermott et al, 2003;Mummery et al, 1998;Poldrack et al, 1999;Price et al, 1997;Roskies et al, 2001;Shivde and Thompson-Schill, 2004], phonological decisions on pictures of objects (relative to semantic, perceptual, and resting conditions) activated bilateral inferior frontal, insula, precentral, and posterior lateral inferior temporal cortices, supramarginal gyri, ante-rior cingulate, supplementary motor area (SMA), cerebellum, and the left thalamus (Table IV). Critically, these phonological activations included 6 of 12 areas that were more activated in the object-naming meta-analysis for low Ͼ high baselines (all in the left hemisphere): frontal operculum (fo); inferior frontal (if-t); cerebellum (cb), insula (in); thalamus (th); and cingulate gyrus (cg).…”

Section: Phonological Activationsupporting

confidence: 89%

Meta‐analyses of object naming: Effect of baseline

Price¹,

Devlin²,

Moore³

et al. 2005

Human Brain Mapping

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Abstract:The neural systems sustaining object naming were examined using the activation likelihood estimation (ALE) meta-analysis approach on the results of 16 previously published studies. The activation task in each study required subjects to name pictures of objects or animals, but the baseline tasks varied. Separate meta-analyses were carried out on studies that used: (1) high-level baselines to control for speech processing and visual input; and (2) low-level baselines that did not control for speech or complex visual processing. The results of the two meta-analyses were then compared directly, revealing a double dissociation in the activation pattern for studies using high and low baselines. To interpret the differential activations, we report two new functional imaging experiments. The aim of the first was to characterize activation differences associated with visual stimuli that are typically used in baseline conditions (complex visual features, simple structures, or fixation). The aim of the second was to classify object-naming regions in terms of whether they were engaged preferentially by semantic or phonological processes. The results reveal a remarkably precise correspondence between the areas identified by the meta-analyses as affected differentially by baseline and the areas that are affected differentially by non-object structure, semantics or phonology. As expected, high-level baselines reduced object-naming activation in areas associated with the processing of complex visual features and speech production. In addition, high-level baselines increased sensitivity to activation in areas associated with semantic processing, visual-speech integration and response selection. For example, activation in the anterior temporal areas that neuropsychological studies have associated with semantic processing was more strongly activated in the context of high-level baselines. These results therefore have implications for understanding the convergence of functional imaging and neuropsychological findings. Hum Brain Mapp 25:70 -82, 2005.

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Section: Phonological Activationsupporting

confidence: 89%

Meta‐analyses of object naming: Effect of baseline

Price¹,

Devlin²,

Moore³

et al. 2005

Human Brain Mapping

180

128

View full text Add to dashboard Cite

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“…Similarly, we propose that the lack of connectivity between the VWFA and the left inferior frontal gyrus may be linked to their inability to successfully engage this region during phonological processing of written words (e.g. (Poldrack et al, 1999;Price, 2000;Pugh et al, 1996). This link between connectivity and reading performance is consistent with the finding that connectivity may increase after effective treatment, as shown by Richards et al (2008).…”

Section: Accepted M Manuscriptsupporting

confidence: 83%

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

et al. 2011

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The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D (2011). The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia. The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia Abstract Developmental dyslexia is a severe reading disorder, which is characterized by dysfluent reading and impaired automaticity of visual word processing. Adults with dyslexia show functional deficits in several brain regions including the so-called "Visual Word Form Area" (VWFA), which is implicated in visual word processing and located within the larger left occipitotemporal VWF-System. The present study examines functional connections of the left occipitotemporal VWF-System with other major language areas in children with dyslexia. Functional connectivity MRI was used to assess connectivity of the VWF-System in 18 children with dyslexia and 24 age matched controls (age 9.7-12.5 years) using five neighbouring left occipitotemporal regions of interest (ROIs) during a continuous reading task requiring phonological and orthographic processing. First, the results revealed a focal origin of connectivity from the VWF-System, in that mainly the VWFA was functionally connected with typical left frontal and parietal language areas in control children. Adjacent posterior and anterior VWF-System ROIs did not show such connectivity, confirming the special role that the VWFA plays in word processing. Second, we detected a significant disruption of functional connectivity between the VWFA and left inferior frontal and left inferior parietal language areas in the children with dyslexia. The current findings add to our understanding of dyslexia by showing that functional disconnection of the left occipitotemporal system is limited to the small VWFA region crucial for automatic visual word processing, and emerges early during reading acquisition in children with dyslexia, along with deficits in orthographic and phonological processing of visual word forms. ÔØ Å ÒÙ× Ö ÔØThe left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the cont...

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“…These two brain regions are critical for language processing (e.g., Chee et al, 1999;Petersen et al, 1990;Poldrack et al, 1999;Price et al, 1996;Tan et al, 2000). In terms of the role of the language areas in the processing of mathematical terms, two other issues need to be discussed.…”

Section: The Language Areas and The Processing Of Mathematical Termsmentioning

confidence: 99%

Neural correlates of numbers and mathematical terms

2012

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Numerical processing has been demonstrated to be subserved typically by the brain regions around the bilateral intraparietal sulcus (IPS). The goal of the current study was to investigate whether the processing of mathematical terms shared the same brain regions with numerical processing. Healthy adult participants performed semantic distance judgment tasks on five types of materials, including geometric terms, algebraic terms, linguistic terms, words for tools and other common objects, and Arabic numbers. Brain activation was measured with functional magnetic resonance imaging (fMRI). The results showed that geometric terms had greater activation than algebraic terms, linguistic terms and tool words in the horizontal IPS, but algebraic terms did not have greater activation than linguistic terms and tool words in this region. Arabic numbers showed greater activation than non-number materials (including geometric terms, algebraic terms, linguistic terms and tool words) in the bilateral IPS, right inferior frontal gyrus and bilateral middle frontal gyrus, but the non-number materials showed stronger activation in the left inferior frontal gyrus and left middle temporal gyrus. These results suggest that the brain area for the processing of numbers (the left IPS) seems to be involved in semantic processing of geometric terms, but not that of other mathematical terms such as algebraic terms. Both algebraic and geometric terms share similar brain organization with basic semantic processing in the left temporal and frontal regions.

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Functional Specialization for Semantic and Phonological Processing in the Left Inferior Prefrontal Cortex

Cited by 1,324 publications

References 69 publications

Meta‐analyses of object naming: Effect of baseline

Meta‐analyses of object naming: Effect of baseline

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

Neural correlates of numbers and mathematical terms

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