Functional Status and Quality of Life in Patients Surviving 10 years After Lung Transplantation

Rutherford, Robert; Fisher, Andrew J.; Hilton, Colin J.; Forty, J.; Hasan, Asif; Gould, F.K.; Dark, John H.; Corris, Paul A.

doi:10.1111/j.1600-6143.2004.00803.x

Cited by 70 publications

(70 citation statements)

References 25 publications

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“…This has also been reported by others [10]. In contrast to the PCS and SGRQ scores, the MCS score showed a similar profile in survivors and non-survivors throughout the follow-up period.…”

Section: Discussionmentioning

confidence: 38%

“…Thereafter, the trajectory of HRQoL is less clear, with patients' wellbeing being hampered by the complications and side effects of immunosuppressive therapy [10]. In fact, few studies have investigated HRQoL longitudinally within the same patients over the long term, and those that exist show substantial heterogeneity in methodology and approach [7].…”

Section: Introductionmentioning

confidence: 99%

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Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Ricotti

Martinelli

Caspani

et al. 2017

Monaldi Arch Chest Dis

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Lung transplantation (LT) increases the life expectancy of patients affected by end stage pulmonary disease; specifically, its ultimate aims are to improve survival and health related quality of life (HRQoL). The aim of the present longitudinal study was to determine the HRQoL trajectory and changes in functional capacity from time of entry in the waiting list for LT to 2 year after LT. The study included sixty-nine outpatients enrolled in a single medical center when they entered the waiting list for LT and who subsequently received it. They were then followed up over 2 years after LT. HRQoL was assessed by the physical and mental component summary (PCS and MCS) scores of the 36-item Short Form Health Survey (SF-36) and Saint George's Respiratory Questionnaire (SGRQ). Psychological distress was evaluated with the General Health Questionnaire (GHQ), and functional capacity was investigated using the six-minute walk test (6MWT) and forced expiratory volume (FEV1). Patients showed low SF-36 PCS (30.5±7.8) and SGRQ total (61.8±17.5) scores at entry in the waiting list, but exhibited significant changes over time after LT (p<0.001). Furthermore, patients who showed an increase of at least 50% in SF36 PCS and SGRQ scores at 6 months survived longer. Both FEV1 and 6MWT distance as well as GHQ scores significantly changed over time, with improvements occurring in the first 6 months after LT but no major changes thereafter. Out of the 69 patients enrolled, 32 died over a median follow-up of 51 months. Although mortality tended to be slightly higher for patients with lower HRQoL at the baseline assessment, this difference was not statistically significant. HRQoL evaluations appear critical in the follow-up of LT candidates, in particularly SGRQ, because of its specificity in targeting respiratory symptoms and functional wellbeing.

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“…This has also been reported by others [10]. In contrast to the PCS and SGRQ scores, the MCS score showed a similar profile in survivors and non-survivors throughout the follow-up period.…”

Section: Discussionmentioning

confidence: 38%

Section: Introductionmentioning

confidence: 99%

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Ricotti

Martinelli

Caspani

et al. 2017

Monaldi Arch Chest Dis

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“…However, it should be done under transplant physician consultation with empiric antibiotic therapy assessing the risk of immunosuppression and drug interaction. Corticosteroid supplementation should be adequately given depending on the dental procedure to avoid adrenal crisis [44][45][46] .…”

Section: Post Transplantation Periodmentioning

confidence: 99%

Transplant Hastalarında Diş Sağlığı

Shahin¹,

Chatra²,

Shenai³

et al. 2014

Arşiv Kaynak Tarama Dergisi

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In today's scenario dentists are more likely to encounter transplant patients for dental care as annually more than 100000 transplantations occur worldwide. Untreated dental disease represents a potential risk for infection and deprived quality of life in transplant patients. These patients are prone for many oral diseases and minor negligence can lead to fatal consequences. This paper aims to provide an insight of transplantation immunology, common oral manifestations and an effective treatment plan depending on the medical condition of the patient In this review, a method used for searching data includes various internet sources and relevant electronic journals from the Pub Med and Medline databases with limits and keywords according to the precise vocabulary "Medical Subject Headings" (MeSH) from January 1984 to January 2012. Prophylactic and therapeutic dental treatment is essential at the primary level to prevent serious infections from oral sources during immunosuppression and the elective dental treatment should be preferably planned during the stable post transplantation period. On the basis of the literature review it is recommended that the dental care in these compromised patients has to be modified to meet their medical status and also depending upon the type of transplantation.

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“…One of the most common complications is infection. Pseudomonas aeruginosa is the most common bacterial pathogen, and cytomegalovirus is the most common viral infection in lung transplant patients (1,24).…”

Section: Lung Transplantmentioning

confidence: 99%

Dental management in transplant patients

Fabuel¹,

Esteve²,

Pérez³

2011

J Clin Exp Dent

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Introduction: Transplant is the replacement with therapeutic purposes, of organs, tissues or cellular material for others, from a donor who is usually a human, alive or dead. In recent years, transplant organs have been developed by the advances that have occurred with immunosuppressive drugs and medical-surgical technology. Due to the frequency of transplants that are performed today, it is common to find these patients in dental clinics. Objectives: To review the literature on oral manifestations in transplant patients and general dental management and according to transplant organs (heart, lung, liver, kidney, pancreas and bone marrow). Material and Methods: For the literature review, we carried out a search in Pubmed / Medline database using limits and keywords according to the controlled vocabulary "Medical Subject Headings" (MeSH). We obtained a total of 30 articles (eight literature reviews, three randomized clinical trials, one cohort study, three case-control studies, eight clinical case series and seven cross-sectional studies). Results and discussion: We describe the most common oral manifestations in transplant patients (viral, bacterial and fungal infections, gingival enlargement secondary to drug therapy and higher risk in the development of oral malignancy) and the special dental management that should be carried out on these patients, generally and specifically according to the type of transplant.

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Functional Status and Quality of Life in Patients Surviving 10 years After Lung Transplantation

Cited by 70 publications

References 25 publications

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Transplant Hastalarında Diş Sağlığı

Dental management in transplant patients

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