Functional study of nasal mucosa in endoscopic sinus surgery and its correlation to electron microscopy of cilia

Sakthikumar, K. R. V.; Ravikumar, A.; Mohanty, Sanjeev; Senthil, K.; L, Somu; Kuruvilla, Sarah

doi:10.1007/s12070-008-0004-2

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…On the one hand, certain studies also demonstrated significant improvement of mucosal appearance 6 months after surgery. Particularly, a substantial decrease in mucosal edema, inflammation, ulceration, and fibrosis was associated with increased ciliated area, improved ciliary orientation (19) , as well as the reversal of basal membrane thickening and epithelial metaplasia 6 months after surgery (37) .…”

Section: Discussionmentioning

confidence: 92%

“…The stages of mucosal recovery after FESS include clean cavity (1-2 weeks), mucosal transition (3-10 weeks), and complete epithelization (11-14 weeks) (16) . However, the existing data on timeframes of postoperative mucociliary clearance recovery are highly contradictory, being indicative of 3-4 (17,18) , 6 (19) , or 12 months (20) required for substantial improvement. Moreover, data on pediatric CRS patients are insufficient.…”

Section: Introductionmentioning

confidence: 99%

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Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

Alekseenko

Karpishchenko

Artyushkin

et al. 2021

Rhin

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Background: The objective of the study is evaluation of ciliary function and mucosal cytology after endoscopic sinus surgery in children with chronic rhinosinusitis (CRS). Methodology: A total of 132 children with CRS who underwent endoscopic sinus surgery, as well as 15 healthy controls were involved in the study. In this follow-up study patients were examined preoperatively, as well as 3, 6, 9, and 12 months after endoscopic sinus surgery. Assessment of ciliary function and sinonasal mucosal cytology was performed using high-speed videomicroscopy. Lund-Kennedy, Lund-Mackay, and sinonasal outcome test 20 (SNOT20) scores were also evaluated. Results: Total SNOT-20, Lund-Mackay, and Lund-Kennedy values significantly decreased after sinus surgery. In contrast, ciliary function and mucosal cytology only tended to improve after 6 months. 9 months after surgery the number of ciliated cells, ciliary beat frequency, cell viability, and ciliary length were significantly higher than preoperatively. The most significant improvement of ciliary function and cell height was observed 12 months after operation, whereas epithelial dystrophy and neutrophil infiltration were significantly reduced. Conclusions: Substantial improvement was observed only in a year after surgery, whereas 0 to 3 months after the surgery ciliary function was severely impaired thus predisposing to recurrent sinusitis or other complications.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

Alekseenko

Karpishchenko

Artyushkin

et al. 2021

Rhin

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“…In the study by Sakthikumar et al [4] consisting of 20 patients, the mean pre-operative saccharin test time was found to be 16.20 min with post-operative mean value of 10.30 min. This proved to be highly significant.…”

Section: Discussionmentioning

confidence: 93%

“…It does not require sophisticated equipment to perform the test and can be reproduced. It is neither digested nor metabolised by the body and does not contribute to the daily calorie intake [4,5].…”

Section: Discussionmentioning

confidence: 99%

Do Nasal Surgeries Affect Mucociliary Clearance?

Aroor

Ali

Somayaji

2016

Indian J Otolaryngol Head Neck Surg

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The study was conducted to assess the impact of different nasal surgeries on the nasal mucociliary clearance mechanism. Mucociliary function of the nasal mucosa of patients who were undergoing various nasal surgeries was assessed by the Saccharin test by placing 5 mg saccharin granule on the anterior end of the inferior turbinate 1 day prior to the surgery. The time required for the test subject to experience a sweet taste was measured in minutes. Post-operatively the test was repeated 6 weeks after the surgery and the test times were compared. A total of 60 patients were part of this study. Of the 60 cases, 19 cases had undergone only septoplasty, 13 cases had undergone only functional endoscopic sinus surgery (FESS), 25 cases had undergone septoplasty with FESS, 2 cases underwent septoplasty with bilateral partial inferior turbinectomy (PIT) and one case was submucous resection (SMR). Significant improvement in nasal mucociliary clearance was observed in all the patients after the procedures. Out of the 19 cases of septoplasty, 57.9 % showed improvement on the right side and 47.4 % on the left side. Out of the 13 cases of FESS, 61.5 % showed improvement on the right side and 69.2 % on the left side. Out of the 25 cases of FESS with septoplasty, 76.0 % showed improvement on both sides. The case of SMR did not show improvement. The 2 cases of septoplasty with PIT showed improvement. Statistically, highly significant improvement of test time was seen postoperatively as compared to pre-operatively. Among the surgical procedures, FESS with septoplasty showed better improvement as compared to the other procedures. Based on the study, we can conclude that nasal surgeries done for correction of septal deviation and rhino sinusitis significantly improves nasal mucociliary clearance mechanism thereby improving the physiological functions of the upper airway.

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“…In the statistics reviewed, [1][2][3][5][6][7][8][9][10] we found that the sample sizes varied from a minimum of 20 to a maximum of 50. Hence, we (based on feasibility) studied a total of 32 subjects in each of the groups (chronic rhinosinusitis, smokers, and controls); a total of 96 subjects were studied.…”

Section: Methodsmentioning

confidence: 99%

Mucociliary Function: Its Variations with Disease

Kumar¹,

Preetham²,

Feshan³

2016

An International Journal Clinical Rhinology

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Introduction: This study compares the nasal mucociliary clearance time of patients with chronic sinusitis (pre-and postoperatively) and smokers, with controls, attending the ear, nose, and throat outpatient department at Southern Railway Headquarters Hospital, Perambur, Chennai. Materials and methods:Saccharin granule was used to study mucociliary clearance as it is safe, easy, fast, and reliable. A total of 32 patients in each group were studied. In chronic rhinosinusitis patients, the test was done preoperatively and 4 weeks postoperatively. Results:The average mucociliary clearance time pre-and postoperatively in chronic rhinosinusitis patients was 29.54 ± 28.68 and 12.17 ± 5.84 respectively. Cigarette smokers had a longer mucociliary clearance time (27.63 ± 21.11) compared with beedi smokers (24.04 ± 24.93). Controls had the fastest mucociliary clearance rate of 9.67 ± 4.62 among the study subjects.Conclusion: Surgery for chronic rhinosinusitis improves both the overall symptoms of chronic rhinosinusitis and the protective functions of the nose and paranasal sinuses. Smokers had an impaired clearance rate compared with normals. As age advances, the mucociliary clearance rate becomes slower.

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Functional study of nasal mucosa in endoscopic sinus surgery and its correlation to electron microscopy of cilia

Cited by 7 publications

References 6 publications

Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

Do Nasal Surgeries Affect Mucociliary Clearance?

Mucociliary Function: Its Variations with Disease

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