Functional study of the transplanted kidney with power Doppler US and time/intensity curves

Farina, Roberto; Pennisi, F.; Rosa, Michele La; Puglisi, C.; Benedetto, A. Di; Campisi, G; Mazzone, G; Ettorre, G

doi:10.1007/s11547-007-0121-0

Cited by 10 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean ± SD of resistive index(RI) was 0.63 ± 0.06 in normal group, 0.76 ± 0.03 in ATI group, and 0.66 ± 0.05 in CAI group; these results matched with the study done by Farina et al (2007) [19] who studied 3 groups: (A) patient without disease, (B) patient with chronic rejection, and (C) patient with acute tubular necrosis; the range of RI for the Group A was 0.6-0.72, the Group B was 0.69-.79, and the group C was 0.68-78. On the other hand, our results disagreed with Ozkan et al (2013) [10] who reported that there was no significant correlation between renal parenchymal stiffness and RI in his population, and this is maybe due to the smaller studied group with ATI in his study.…”

Section: Discussionsupporting

confidence: 80%

Role of ultrasound, Color duplex Doppler and sono-elastography in the evaluation of renal allograft complications

El-Motaal

Dawoud

Sherif

et al. 2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: Renal transplantation could be considered for patients with end-stage renal disease. Ultrasonography is the imaging method chosen for renal allograft evaluation early in the postoperative period. Sono-elastography is used to estimate tissue stiffness. This study aimed to assess the correlation between sono-elastography and renal allograft histopathology in patients who had transplanted kidney and determine the efficacy of grayscale ultrasound, sonoelastography, and color duplex in evaluation renal allograft complications and correlation with renal function. Results: Forty patients (26 males and 14 females) who underwent renal transplantation were included. Their ages ranging from 10:52 years; they all subjected to ultrasound, color Doppler, sono-elastography, and histopathology. The studded patients were divided into 3 groups according to histopathology: patient with normal results, patients with ATI, and patients with CAI. The difference between the mean elasticity values between the three groups was statistically highly significant (p value < 0.001) with high specificity, sensitivity, and accuracy in differentiating ATI and normal groups and also CAI and normal groups, while the lowest sensitivity noticed in differentiating between ATI and CAI groups that is mean elasticity was good to differentiating between ATI and normal groups and also between CAI and normal groups while it was less in differentiating between ATI and CAI groups. As regards the RI, the highest sensitivity of the RI was in differentiating ATI and normal with high sensitivity, specificity, and accuracy, and the lowest sensitivity, specificity, and accuracy of RI were in differentiating CAI and normal groups. Conclusion: Transplanted renal allograft could be assessed by combined US, color duplex Doppler, and sonoelastography examination; also we can detect posttransplant complications early. Sono-elastography could be an efficient noninvasive method to diagnose and monitor kidney allograft rejection and follow-up of the renal allograft, which may give a further and possibly earlier prognostic index for chronic dysfunction in addition to serum creatinine.

show abstract

Section: Discussionsupporting

confidence: 80%

Role of ultrasound, Color duplex Doppler and sono-elastography in the evaluation of renal allograft complications

El-Motaal

Dawoud

Sherif

et al. 2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

show abstract

“…In addition, CEUS can analyse renal blood flow quantitatively [43]. Through analyzing the echo volume and changes in the contrast agent microbubbles in the ROI over time to generate the TIC, quantitative parameters obtained from the TIC can be used to objectively and accurately quantify renal cortical haemodynamic changes [44]. The study by Dong et al [45] showed that renal function changes in patients with DN can be monitored by changes in the TIC curve parameters of the renal cortex.…”

Section: Discussionmentioning

confidence: 99%

Intrarenal delivery of bFGF-loaded liposome under guiding of ultrasound-targeted microbubble destruction prevent diabetic nephropathy through inhibition of inflammation

Sheng

Zheng

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Basic fibroblast growth factor (bFGF) has shown great therapeutic effects for diabetic nephropathy (DN). However, its clinical applications are limited due to its short half-life, low stability and poor penetration. Herein, a bFGF-loaded liposome (bFGF-lip) was constructed and combined with ultrasound-targeted microbubble destruction (UTMD) to overcome these drawbacks. bFGF-lip exhibited spherical morphology with a diameter of 171.1 ± 14.2 nm and a negative zeta potential of -5.15 ± 2.08 mV, exhibiting a sustained-release profile of bFGF. DN rat models were successfully induced by streptozotocin. After treatment with bFGF-lip + UTMD, the concentration of bFGF in kidney of DN rats was significantly enhanced in comparison with free bFGF treatment. Additionally, the morphology and the function of the kidneys were obviously recovered after bFGF-lip + UTMD treatment as shown by ultrasonography and histological analyse. The molecular mechanism was associated with the inhibition of renal inflammation. After treatment with bFGF-lip + UTMD, the activation of NF-κB was obviously reduced in the renal tissues, and downstream inflammatory mediators including TGF-β1, MCP-1, IL-6 and IL-1β were also down regulated. In addition, inflammation-induced cellular apoptosis of renal tubular cells was also significantly inhibited by detecting Bax, caspase-3 and Bcl-2. Therefore, bFGF-lip in combination with UTMD might be a potential strategy to reverse the progression of early DN.

show abstract

“…US contrast agents (USCAs) nowadays in use are safe in patients with renal diseases [6] and have been used for functional evaluation of the transplanted kidney [7,8]. CEUS (contrast-enhanced ultrasonography) performed with Sonazoid (Sonazoid™, Daiichi-Sankyo, Tokyo) as contrast medium has been tested on patients with chronic renal failure, showing that USCA enhancement decreases with the severity of renal function impairment [9].…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

et al. 2018

View full text Add to dashboard Cite

show abstract

Functional study of the transplanted kidney with power Doppler US and time/intensity curves

Cited by 10 publications

References 26 publications

Role of ultrasound, Color duplex Doppler and sono-elastography in the evaluation of renal allograft complications

Role of ultrasound, Color duplex Doppler and sono-elastography in the evaluation of renal allograft complications

Intrarenal delivery of bFGF-loaded liposome under guiding of ultrasound-targeted microbubble destruction prevent diabetic nephropathy through inhibition of inflammation

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

Contact Info

Product

Resources

About