Functional supramolecular micelles driven by the amphiphilic complex of biotin-acyclic cucurbituril and cannabidiol for cell-targeted drug delivery

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

“…The applied supramolecular method proved to be superior because it allowed for exact control of the ratio of camptothecin (CPT) to cisplatin (Pt), two drugs which often could not be precisely regulated in different delivery systems. 288 Among cucurbit[n] uril-based amphiphiles 289,290 that self-assemble into nanomaterials as functional supramolecular micelles (FMS), many examples of ADA/CB[n] system could be employed for perspective biological and technological application, 291 more specifically, for cell-targeted drug delivery 292 or even as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy. 293 In these examples FSMs exhibited favorable characteristics such as high bioavailability, stability, precise targeting, and excellent delivery efficiency, making them highly promising for use in the drug delivery domain.…”

Supramolecular Chemotherapy with Cucurbit[n]urils as Encapsulating Hosts

“…This amphiphilic complex showed high stability, bioavailability, and antitumor target specificity and efficiency in the breast cancer cell line (MCF-7) as demonstrated by MTT test results. The complex when loaded with Rhodamine B also revealed tumor specificity by aggregating on the surface of tumor cells . Tonga et al constructed a synthetic host–guest supramolecular system capable of a controllable assembly and disassembly of multimodular systems within living cells .…”

“…The complex when loaded with Rhodamine B also revealed tumor specificity by aggregating on the surface of tumor cells. 69 Tonga et al constructed a synthetic host−guest supramolecular system capable of a controllable assembly and disassembly of multimodular systems within living cells. 70 In their system, Ru-catalyst embedded-diamino hexane-terminated gold nanoparticles (AuNP-NH 2 ) were complexed with complementary CB [7] to form supramolecular nanoparticles, which dramatically reduced the cytotoxicity of AuNP-NH 2 in the endosomes due to the capping of CB [7] molecules.…”

Acyclic Cucurbit[n]urils: Effective Taste Masking Nanocontainers for Cationic Bitter Compounds

“…[34,35] ACBs can recognize suitable guests, dyes and drugs, and are used as chemosensors, [36] sequestration agents, [37,38] as well as drug carriers. [39,40] It has been reported that CB [7] could form stable host-guest complexes with denatonium benzoate (DB) through host-guest interactions, and effectively mask the bitterness of DB in animal study. [41] Given that the size of the hydrophobic cavity of the ACB scaffold can be tuned by the aromatic units attached on its two ends, [42] we have designed and prepared three highly water-soluble ACB derivatives which bear eight anionic carboxylate groups.…”