This study aimed to assess the effects of convective drying at different temperatures (50, 60, and 70 °C) on the technological and chemical properties of Pereskia sp. leaf powders and to identify the most accurate mathematical model for describing their drying kinetics. Drying kinetics were modeled using four mathematical models: Henderson and Pabis, Lewis, Logarithmic, and Page. The Page and Logarithmic models provided the best fit for the drying kinetics of both species, with high coefficients of determination (R2 > 0.98) and low MSE and χ2 values, indicating their suitability for describing the drying behavior of Pereskia leaves. Enthalpy and entropy decreased with increasing temperature, while Gibbs free energy increased, and effective diffusivity was not affected by temperature. These changes directly affected the powders’ color, density, compressibility, wettability, water activity, chlorophyll, and bioactive components, including carotenoids, proteins, and phenolics. Notably, P. grandifolia powders retained higher levels of ash, protein, and lipids, indicating greater nutritional value, while P. aculeata powders exhibited higher solubility and lower water activity, suggesting superior technological properties for industrial applications. The findings highlight the potential of Pereskia species as functional ingredients in food products, with implications for optimizing drying processes to enhance both nutritional and industrial value.