Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications

Pardeshi, Sagar R.; Damiri, Fouad; Zehravi, Mehrukh; Joshi, Rohit; Kapare, Harshad S.; Prajapati, Mahendra; Munot, Neha; Berrada, Mohamed Saleh; Giram, Prabhanjan S.; Rojekar, Satish; Ali, Faraat; Rahman, Habibur; Barai, Hasi Rani

doi:10.3390/polym14153126

Cited by 47 publications

(27 citation statements)

References 240 publications

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“…Researchers have created hydrogel composite materials made of natural, inexpensive, nontoxic, and biodegradable components to address these main limitations relating to cost and potential environmental issues. For instance, combining the hydrogel with a substance that has a greater adsorption ability may dramatically increase the sorption capacity [59]. For example, the different ways to fabricate CS-based composite hydrogels are:…”

Section: Based Polymer For Composites Hydrogelmentioning

confidence: 99%

Production of Polymer Hydrogel Composites and Their Applications

Sayed

2023

J Polym Environ

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Hydrogels are three-dimensional cross-linked stable network insoluble in water, which gives them a remarkable capacity to absorb both water and biological fluids. Hydrogel has been synthesized from natural or synthetic polymers and/or monomers, which have made tremendous advancements in many different applications. Composite hydrogel is a type of hydrogel prepared by grafting hydrophilic groups, such as hydroxyl (–OH), carboxylic acid (–COOH), imide (–CONH), sulfonic acid (–SO3H), amine (–NH2), and amide (–CONH2), into the polymer chain’s backbone and adding some additives such as kaolin, zeolite, or even different types of nanoparticles. Whereas the polymeric composite hydrogels exhibit stimuli for different properties such as pH, temperature, or light, which may affect swelling, mechanical properties, and self-healing, which in turn play vital roles in different areas. Hence, numerous efforts have been made to synthesize polymer-based composited hydrogels via physical or chemical crosslinking techniques to enhance their physiochemical, biological, and many other properties. Many researchers are currently paying attention to hydrogels and their applications, including wastewater treatment and purification, medical and biomedical applications, agricultural applications, and many other industrial applications. The aim of this review is to summarize the classification of composite hydrogels based on their chemical and physical crosslinking techniques, in addition to the different polymers and additives used to prepare composite hydrogels. Furthermore, the impact of hydrogel on health and the environment has been discussed. Other significant issues were also presented, including the challenges that face hydrogel production and application, which have been discussed.

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Section: Based Polymer For Composites Hydrogelmentioning

confidence: 99%

Production of Polymer Hydrogel Composites and Their Applications

Sayed

2023

J Polym Environ

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“…Hydrogels are three-dimensional, cross-linked, and elastic polymer networks with hydrophilic groups such as hydroxyl, amide, and carboxyl that expand in water and biological fluids [ 42 , 43 ]. Numerous attempts have been undertaken in the field of wastewater treatment using hydrogels.…”

Section: Nanomaterials In Wastewater Treatmentmentioning

confidence: 99%

Recent Advances in Adsorptive Nanocomposite Membranes for Heavy Metals Ion Removal from Contaminated Water: A Comprehensive Review

Damiri

Andra²,

Kommineni

et al. 2022

Materials

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Water contamination is one of the most urgent concerns confronting the world today. Heavy metal poisoning of aquatic systems has piqued the interest of various researchers due to the high toxicity and carcinogenic consequences it has on living organisms. Due to their exceptional attributes such as strong reactivity, huge surface area, and outstanding mechanical properties, nanomaterials are being produced and employed in water treatment. In this review, recent advances in the use of nanomaterials in nanoadsorptive membrane systems for wastewater treatment and heavy metal removal are extensively discussed. These materials include carbon-based nanostructures, metal nanoparticles, metal oxide nanoparticles, nanocomposites, and layered double hydroxide-based compounds. Furthermore, the relevant properties of the nanostructures and the implications on their performance for water treatment and contamination removal are highlighted. The hydrophilicity, pore size, skin thickness, porosity, and surface roughness of these nanostructures can help the water permeability of the nanoadsorptive membrane. Other properties such as surface charge modification and mechanical strength can improve the metal adsorption effectiveness of nanoadsorptive membranes during wastewater treatment. Various nanocomposite membrane fabrication techniques are also reviewed. This study is important because it gives important information on the roles of nanomaterials and nanostructures in heavy metal removal and wastewater treatment.

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“…In this work, an Acrylamide/Propargyl acrylate (AM/PA) hydrogel is used, simultaneously, as a matrix for the holographic pattern fabrication and for the functionalization with single-strand thiolated oligonucleotides as a biorecognition element. Hydrogels are attractive platforms for bioanalysis thanks to their ability to retain large amounts of water, acting like biological tissues, optimal for biological interactions [ 12 , 13 , 14 , 15 , 16 ]. Hydrogel-based sensors found numerous applications in clinical diagnostics, biomedical research, environmental monitoring, and food testing [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Surface Micro-Patterned Biofunctionalized Hydrogel for Direct Nucleic Acid Hybridization Detection

et al. 2023

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The present research is focused on the development of a biofunctionalized hydrogel with a surface diffractive micropattern as a label-free biosensing platform. The biosensors described in this paper were fabricated with a holographic recording of polyethylene terephthalate (PET) surface micro-structures, which were then transferred into a hydrogel material. Acrylamide-based hydrogels were obtained with free radical polymerization, and propargyl acrylate was added as a comonomer, which allowed for covalent immobilization of thiolated oligonucleotide probes into the hydrogel network, via thiol-yne photoclick chemistry. The comonomer was shown to significantly contribute to the immobilization of the probes based on fluorescence imaging. Two different immobilization approaches were demonstrated: during or after hydrogel synthesis. The second approach showed better loading capacity of the bioreceptor groups. Diffraction efficiency measurements of hydrogel gratings at 532 nm showed a selective response reaching a limit of detection in the complementary DNA strand of 2.47 µM. The label-free biosensor as designed could significantly contribute to direct and accurate analysis in medical diagnosis as it is cheap, easy to fabricate, and works without the need for further reagents.

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Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications

Cited by 47 publications

References 240 publications

Production of Polymer Hydrogel Composites and Their Applications

Production of Polymer Hydrogel Composites and Their Applications

Recent Advances in Adsorptive Nanocomposite Membranes for Heavy Metals Ion Removal from Contaminated Water: A Comprehensive Review

Surface Micro-Patterned Biofunctionalized Hydrogel for Direct Nucleic Acid Hybridization Detection

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