Functional topography of the thalamo-cortical system during development and its relation to cognition

Steiner, Leonie; Federspiel, Andrea; Slavova, Nedelina; Wiest, Roland; Grunt, Sebastian; Steinlin, Maja; Everts, Regula

doi:10.1016/j.neuroimage.2020.117361

Cited by 39 publications

(37 citation statements)

References 57 publications

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“…This is consistent with the recent work of Jang et al 55 where they found an increased thalamocortical between the lesioned and contralesional hemispheres in the case of a stroke patient. This result is particularly important in the case of NAIS given the fact that thalamocortical network connectivity is altered during brain maturation 56,57 and decreased connectivity was linked to motor impairments 58 …”

Section: Discussionmentioning

confidence: 99%

A connectome‐based approach to assess motor outcome after neonatal arterial ischemic stroke

Harrach

Pretzel

Groeschel

et al. 2021

Ann Clin Transl Neurol

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Objective Studies of motor outcome after Neonatal Arterial Ischemic Stroke (NAIS) often rely on lesion mapping using MRI. However, clinical measurements indicate that motor deficit can be different than what would solely be anticipated by the lesion extent and location. Because this may be explained by the cortical disconnections between motor areas due to necrosis following the stroke, the investigation of the motor network can help in the understanding of visual inspection and outcome discrepancy. In this study, we propose to examine the structural connectivity between motor areas in NAIS patients compared to healthy controls in order to define the cortical and subcortical connections that can reflect the motor outcome. Methods Thirty healthy controls and 32 NAIS patients with and without Cerebral Palsy (CP) underwent MRI acquisition and manual assessment. The connectome of all participants was obtained from T1‐weighted and diffusion‐weighted imaging. Results Significant disconnections in the lesioned and contra‐lesioned hemispheres of patients were found. Furthermore, significant correlations were detected between the structural connectivity metric of specific motor areas and manuality assessed by the Box and Block Test (BBT) scores in patients. Interpretation Using the connectivity measures of these links, the BBT score can be estimated using a multiple linear regression model. In addition, the presence or not of CP can also be predicted using the KNN classification algorithm. According to our results, the structural connectome can be an asset in the estimation of gross manual dexterity and can help uncover structural changes between brain regions related to NAIS.

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Section: Discussionmentioning

confidence: 99%

A connectome‐based approach to assess motor outcome after neonatal arterial ischemic stroke

Harrach

Pretzel

Groeschel

et al. 2021

Ann Clin Transl Neurol

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“…Decreased cerebral blood flow is thought to be associated with reduced functional and structural reorganization capacities, which in turn might lead to slower cognitive recovery. During childhood, brain development undergoes shifts in functional connectivity 58 , 59 , hemodynamic properties 60 , cortical surface expansion 61 , increases in white matter volume 62 and decrease in synapse density due to pruning 63 . Cerebral blood flow plays an important role during these changes, as it supplies blood and nutrients to the brain, supports ongoing development and likely reflects decreased synaptic density 63 , 64 .…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and cognitive outcome after pediatric stroke in the middle cerebral artery

Steiner

Federspiel

Jaros

et al. 2021

Sci Rep

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Adaptive recovery of cerebral perfusion after pediatric arterial ischemic stroke (AIS) is sought to be crucial for sustainable rehabilitation of cognitive functions. We therefore examined cerebral blood flow (CBF) in the chronic stage after stroke and its association with cognitive outcome in patients after pediatric AIS. This cross-sectional study investigated CBF and cognitive functions in 14 patients (age 13.5 ± 4.4 years) after pediatric AIS in the middle cerebral artery (time since AIS was at least 2 years prior to assessment) when compared with 36 healthy controls (aged 13.8 ± 4.3 years). Cognitive functions were assessed with neuropsychological tests, CBF was measured with arterial spin labeled imaging in the anterior, middle, and posterior cerebral artery (ACA, MCA, PCA). Patients had significantly lower IQ scores and poorer cognitive functions compared to healthy controls (p < 0.026) but mean performance was within the normal range in all cognitive domains. Arterial spin labeled imaging revealed significantly lower CBF in the ipsilesional MCA and PCA in patients compared to healthy controls. Further, we found significantly higher interhemispheric perfusion imbalance in the MCA in patients compared to controls. Higher interhemispheric perfusion imbalance in the MCA was significantly associated with lower working memory performance. Our findings revealed that even years after a pediatric stroke in the MCA, reduced ipsilesional cerebral blood flow occurs in the MCA and PCA and that interhemispheric imbalance is associated with cognitive performance. Thus, our data suggest that cerebral hypoperfusion might underlie some of the variability observed in long-term outcome after pediatric stroke.

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“…The pallidum, one component of the basal ganglia, was found to be associated with the cognitive performance of patients ( 71 ). The thalamus had complex connections with the prefrontal regions and thalamo-cortical connections had been found to be involved in various cognitive processes ( 72 ). Therefore, we suspected that the increased functional connectivity of the pallidum and thalamus in this study might reflect an attempt to reinstate homeostasis in functions related to cancer and the visceral sympathetic activation.…”

Section: Discussionmentioning

confidence: 99%

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

Liu

Yin

et al. 2022

Front. Neurol.

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IntroductionSome previous studies in patients with lung cancer have mainly focused on exploring the cognitive dysfunction and deficits of brain function associated with chemotherapy. However, little is known about functional brain alterations that might occur prior to chemotherapy. Therefore, this study aimed to evaluate brain functional changes in patients with nonchemotherapy before chemotherapy with non-small cell lung cancer (NSCLC).MethodsResting-state functional MRI data of 35 patients with NSCLC and 46 matched healthy controls (HCs) were acquired to construct functional brain networks. Graph theoretical analysis was then applied to investigate the differences of the network and nodal measures between groups. Finally, the receiver operating characteristic (ROC) curve analysis was performed to distinguish between NSCLC and HC.ResultsDecreased nodal strength was found in the left inferior frontal gyrus (opercular part), inferior frontal gyrus (triangular part), inferior occipital gyrus, and right inferior frontal gyrus (triangular part) of patients with NSCLC while increased nodal strength was found in the right pallidum and thalamus. NSCLC also showed decreased nodal betweenness in the right superior occipital gyrus. Different hub regions distribution was found between groups, however, no hub regions showed group differences in the nodal measures. Furthermore, the ROC curve analysis showed good performance in distinguishing NSCLC from HC.ConclusionThese results suggested that topological abnormalities of pallido-thalamo-cortical circuit in functional brain network might be related to NSCLC prior to chemotherapy, which provided new insights concerning the pathophysiological mechanisms of NSCLC and could serve as promising biological markers for the identification of patients with NSCLC.

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Functional topography of the thalamo-cortical system during development and its relation to cognition

Cited by 39 publications

References 57 publications

A connectome‐based approach to assess motor outcome after neonatal arterial ischemic stroke

A connectome‐based approach to assess motor outcome after neonatal arterial ischemic stroke

Cerebral blood flow and cognitive outcome after pediatric stroke in the middle cerebral artery

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

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