The article researches the transformation of the science functions in the process of changing the scientific rationality type in the conditions of the information society formation. The relevance of the research topic is stipulated by the need for scientific analysis and philosophical understanding of the large-scale changes occurring in modern science under the influence of informatization processes. The theoretical basis of the study are the general philosophical principles - the principles of systematicity, comprehensiveness, concreteness of the study, as well as such socio-philosophical methods as specifically historical, historical-retrospective, comparative-historical method, the method of unity of historical and logical in social cognition. Comparative analysis, interdisciplinary synthesis and other techniques of general scientific methodology are also used. The influence of socio-cultural conditions on the functional transformations of post-non-classical science is substantiated. The basic tendencies of functional transformation of science are revealed: transition to development of complex scientific programs; the convergence of research programs with high-tech manufacturing practices, the integration of computer technologies with methodological tools; the commensuration of subject lines of scientific knowledge with the conditions of formation of socially-human complexes; the coordination of rational-cognitive ethos of science with cultural universals; the extension of the intra-scientific reflection field and the formation of extra-scientific reflection forms.