2017
DOI: 10.1152/ajpheart.00581.2016
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Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

Abstract: Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) are expected to have a major role in preserving brain health in older individuals. M… Show more

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Cited by 399 publications
(394 citation statements)
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References 304 publications
(342 reference statements)
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“…During periods of intense neuronal activity, there is a requirement for rapid increases in oxygen and glucose delivery. This is ensured by neurovascular coupling (functional hyperemia), a vital mechanism of regulation of CBF that maintains optimal microenvironment of cerebral tissue by adjusting local blood flow to local neuronal activity in a moment-to-moment manner (Attwell et al 2010;Tarantini et al 2015Tarantini et al , 2016Toth et al 2016;Toth et al 2014aToth et al , 2015aToth et al , 2015bToth et al , 2017Tucsek et al 2014). There is increasing evidence that neurovascular dysfunction is causally related to cognitive decline in models of aging (Tarantini et al 2015(Tarantini et al , 2016), yet, the effects of WBI on cerebromicrovascular function have never been investigated.…”
mentioning
confidence: 99%
“…During periods of intense neuronal activity, there is a requirement for rapid increases in oxygen and glucose delivery. This is ensured by neurovascular coupling (functional hyperemia), a vital mechanism of regulation of CBF that maintains optimal microenvironment of cerebral tissue by adjusting local blood flow to local neuronal activity in a moment-to-moment manner (Attwell et al 2010;Tarantini et al 2015Tarantini et al , 2016Toth et al 2016;Toth et al 2014aToth et al , 2015aToth et al , 2015bToth et al , 2017Tucsek et al 2014). There is increasing evidence that neurovascular dysfunction is causally related to cognitive decline in models of aging (Tarantini et al 2015(Tarantini et al , 2016), yet, the effects of WBI on cerebromicrovascular function have never been investigated.…”
mentioning
confidence: 99%
“…Vascular contributions to cognitive impairment and dementia (VCID) in aging have garnered much interest in the past decade (Corriveau et al 2016;Csiszar et al 2017;Gorelick et al 2011;Snyder et al 2015;Toth et al 2017;Tucsek et al 2017). There are numerous agerelated vascular pathologies underlying VCID.…”
Section: Introductionmentioning
confidence: 99%
“…There are numerous agerelated vascular pathologies underlying VCID. It has become evident that in addition to pathologies affecting the larger cerebral arteries (e.g., atherosclerosis promoting cerebral ischemia) and cerebral microvessels (including arteriosclerosis, blood-brain barrier disruption, microvascular rarefaction, microvascular amyloid deposition, microhemorrhages) (Tucsek et al 2014a(Tucsek et al , b, 2017Ungvari et al 2017b), functional impairment of cerebral microvessels resulting in dysregulation of cerebral blood flow (CBF) also has a critical role in the agerelated decline of brain function Tarantini et al 2016;Toth et al 2017;Zlokovic 2011).…”
Section: Introductionmentioning
confidence: 99%
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