Functional vascular endothelial growth factor gene polymorphisms and diabetes: Effect on coronary collaterals in patients with significant coronary artery disease

Lin, Tsung‐Hsien; Wang, Chiao-Ling; Su, Ho‐Ming; Hsu, Po-Chao; Juo, Suh‐Hang Hank; Voon, Wen‐Chol; Shin, Shyi–Jang; Lai, Wen‐Ter; Sheu, Sheng‐Hsiung

doi:10.1016/j.cca.2010.07.002

Cited by 41 publications

(31 citation statements)

References 37 publications

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“…Demonstration of non-infarct-related artery chronic total occlusion (CTO) rates within groups (12.7% vs. 2.5%, p < 0.001); ICD -inadequate collateral development; ACD -adequate collateral development which leads to induced coronary narrowing and collateral supplying; however, previous clinical and experimental studies on collateral development, particularly in diabetic patients, have reported conflicting results. It is known that endothelial dysfunction, decreased nitric oxide (NO) synthesis, decreased endothelial progenitor cell (EPC) proliferation, and impaired vascular endothelial growth factor (VEGF)-induced EPC proliferation are well-known characteristics of DM [8,18,19]. In contrast, these factors are crucial for collateral development.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance and determinants of prompt recruitment collaterals during primary percutaneous coronary intervention

et al. 2017

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A b s t r a c tBackground: Due to ischaemic time delays from the chest pain occurrence in acute ST elevation myocardial infarction (STEMI), prompt recruitment collaterals (PRCCs) to infarct-related artery (IRA) are the major protective structures during this period. Aim:We aimed to investigate the clinical significance and determinants of PRCCs in acute STEMI patients. Methods:A total of 1375 consecutive acute STEMI patients were prospectively enrolled in the study. The patients were divided into two groups, according to PRCCs to IRA; Rentrop ≤ 1 were defined as inadequate collateral development (ICD) group and Rentrop ≥ 2 defined as adequate collateral development (ACD) group.Results: Patients in the ICD group had higher incidence of baseline risk characteristics, including older age, hypertension, and diabetes mellitus; however, pre-infarct angina incidence was lower than in the ACD group (p < 0.05 for all). In addition, the ICD group had worse haemodynamic status on admission and 30-day mortality. Compared to the ACD group, the non-IRA chronic total occlusion (CTO), peak troponin-T, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high sensitivity C-reactive protein (hs-CRP) levels were higher in the ICD group. On multivariate logistic regression analysis, non-IRA CTO (b = 3.114, 95% CI 1.382-7.017, p < 0.006) with pre-infarction angina together with higher values of peak troponin-T, NT-proBNP, and hs-CRP were associated with PRCCs in acute STEMI. Conclusions:Taking into account that the main message of the study is that if patients have higher cardiac biomarkers and adverse clinical findings (which, of note, may show the extent of myocardial infarction) and have non-IRA CTO, there is a higher chance that they will have inadequate collateralisation.

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Section: Discussionmentioning

confidence: 99%

Clinical significance and determinants of prompt recruitment collaterals during primary percutaneous coronary intervention

et al. 2017

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“…Differences in coronary collateral growth may be one of the pathophysiological mechanisms responsible for the J-curve phenomenon in the relationship between diastolic blood pressure and cardiovascular risk. In experimental animal studies, hyperlipidemia, particularly hypercholesterolemia, was shown to be an inhibitor of arteriogenesis (Lin et al, 2010). However, data on the relationship between coronary collateral formation and hyperlipidemia remain controversial, partly because of the use of different techniques for grading the collateral flow (van der Hoeven et al, 2013).…”

Section: Traditional Risk Factorsmentioning

confidence: 99%

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

Sun

Shen

Lü

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods: Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results: Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high collateralization (for all comparisons, P<0.05). In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein (hsCRP) compared with those with high collateralization. Multivariate analysis revealed that age of ≥65 years, female gender, diabetes, no history of hypertension, dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were independently associated with low coronary collateralization. Conclusions: Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation.

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“…Reduced VEGF secretion was reportedly linked to poor pregnancy outcomes, including fetal loss (3,4). VEGF expression is genetically controlled, and polymorphisms in the VEGF gene were identified, some of which [þ405C>G (rs2010963) and À2578C>A (rs699947)] were associated with altered VEGF production (5,6).…”

mentioning

confidence: 99%

Effect of the functional VEGFA −583C/T variant on vascular endothelial growth factor levels and the risk of recurrent spontaneous miscarriage

Al-Khateeb

Mustafa

Sater

et al. 2011

Fertility and Sterility

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Functional vascular endothelial growth factor gene polymorphisms and diabetes: Effect on coronary collaterals in patients with significant coronary artery disease

Cited by 41 publications

References 37 publications

Clinical significance and determinants of prompt recruitment collaterals during primary percutaneous coronary intervention

Clinical significance and determinants of prompt recruitment collaterals during primary percutaneous coronary intervention

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

Effect of the functional VEGFA −583C/T variant on vascular endothelial growth factor levels and the risk of recurrent spontaneous miscarriage

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