Parkinson' s disease (PD) is the second most common neurodegenerative disorder and it affects 0.3% of the population at large 1 . Pathologically, PD is characterized by the loss of the dopaminergic neurons from the substantia nigra pars compacta, causing the reduction of the striatal dopamine levels 2 . Clinically, PD is marked by the presence of tremors at rest, rigidity and bradykinesia 2 . With the PD progression, other impairments occur, such as postural instability 3 and gait dysfunctions 4 . These impairments result in a greater propensity to falls [5][6][7] , as well as a reduced capacity to walk 8 , and lead to progressive functional restraints. These physical aspects contribute to worsen the quality of life (QoL) in patients with PD 9-13 .QoL is a multidimensional concept that refers to an individual' s subjective perception concerning their life and other aspects, such as familial relationships, the patient' s own health, financial issues, housing, social life and leisure
ABSTRACTParkinson's disease (PD) is characterized by motor symptoms that cause the decline of functional capacity and affect the quality of life (QoL). Objective: To evaluate the impact of changes in balance and walking capacity on the PD. Methods: The instruments used were: Unified Parkinson's Disease Rating Scale (UPDRS), modified Hoehn and Yahr Scale (HY), Schwab and England scale (SE), quality of life questionnaire (PDQ-39), Berg balance Scale (BBS) and six-minute walk test (6MWT). Results: Thirty-six patients with mean disease duration of 7.3 years were assessed. Lower scores on the BBS and shorter distances walked during the 6MWT correlated with a poorer perception of QoL. This correlation occurred at the expense of the mobility and daily living activities domains. Conclusion: Our results indicated that the impairment in balance while performing functional activities and the reduction in walking capacity are important factors that negatively affect the perception of QoL in PD patients.Key words: Parkinson's disease, quality of life, postural balance.
RESUMOA doença de Parkinson (DP) é caracterizada por sintomas motores que causam declínio da capacidade funcional e afetam a qualidade de vida (QV). Objetivo: Avaliar o impacto das mudanças no equilíbrio e na capacidade de marcha em doentes com DP. Métodos: Foram utilizados instrumentos específicos para avaliação clínica da DP: Escala Unificada de Avaliação da Doença de Parkinson (UPDRS), Escala de Hoehn e Yahr (HY) modificada, Escala de Schwab e England (SE), questionário de qualidade de vida (PDQ-39), Escala de Equilíbrio de Berg (EEB) e teste de caminhada de seis minutos (TC6M). Resultados: Foram avaliados 36 pacientes, com duração média da doença de 7,3 anos. Menores pontuações na EEB e menores distâncias percorridas durante o TC6M mostraram correlação com pior percepção da QV. Essa correlação ocorreu em detrimento dos domínios de mobilidade e atividades de vida diária. Conclusão: Nossos resultados indicaram que o prejuízo no equilíbrio durante a realização de atividades funcio...