Functional β-cyclodextrin coating by electrodeposition on stainless steel for drug loading and release

Abstract

β-Cyclodextrin(β-CD) can be used for drug loading and release in biomedical application. β-Cyclodextrinsalicylate(β-CD-S) was synthesized by transesterification and then was electrodeposited on the surface of stainless steel(SS) by the anodic electrooxidation polymerization of the salicylate. 1 H NMR spectrometry was used to determine the structure of β-CD-S. FTIR spectroscopy and XPS were applied to verifying the synthesized β-CD-S and the existence of the electrodeposited layer on the SS surface, respectively. Tafel plots and electrochemical impedance spectroscopy(EIS) technologies were used to estimate the corrosion resistance of β-CD-covered stainless steel. Electrochemical quartz crystal microbalance was applied to determining the drug loading of the stainless steel before and after its modification. E. coli was selected as a harmful microbe to evaluate the antibacterial properties of the stainless steel with the comparison of optical density values.

Effective Treatment of Knee Osteoarthritis Using a Nano‐Enabled Drug Acupuncture Technology in Mice

“…This led to the deposition of poly (phenoxy) film, in an irreversible fashion, which endowed the nd ‐Acu with the ability to load payload(s) of interest (Figure 1E , left panel). [ 18 ] The cyclic voltammetry curves revealed the degree of electrodeposition in a cycle number‐sensitive fashion; the electrodeposition was largely completed from cycle #1 to #5. Owing to the insulator nature of β‐CD‐S, we concluded the β‐CD‐S modification when the cycle number reached ten because the detected current was closed to 0 A ( a.k.a .…”

“…[ 19 ] The equivalent circuit of the needles was proposed in the form of a series connection of parallel RC circuits. [ 18 ] The charge‐transfer resistance was calculated from the Nyquist plots, shown in Table S2 (Supporting Information). The resistance of the electrodeposited needles was 3.476 × 10 5 Ω cm −2 , higher than that of pristine needles (1.871×10 5 Ω cm −2 ).…”

“…The synthesis of nd ‐Acu needles was designed based on literature with minor modifications. [ 18 ] Briefly, 11.3 g (0.01 mol) β‐CD was added to a 300‐mL beaker containing 33.3 mL ethanol and 66.7 mL distilled water. The suspension was mixed at 60 °C under magnetic stirring (1,000 rpm) for 1 h. Then, the mixture was naturally cooled to 40 °C at room temperature under magnetic stirring (1,000 rpm).…”

Sensors Based on Molecularly Imprinted Polymers

“…Similarly to pyrrole, cyclodextrins can be polymerized by an electrochemical way giving the opportunity to control the process by adjusting of parameters like voltage range, rate of voltage change, number of cycles etc. Layer of cyclodextrins overs an electrode is easily producible in an electrochemical process [68][69][70][71][72][73]. Overview of the aforementioned materials is given in table 1.…”