Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Shigeoka, Daiki; Yamazaki, Takahiro; Ishikawa, Tomoya; Miike, K.; Fujiwara, Kazue; Ide, Taisei; Oshima, Akito; Hashimoto, Tatsuya; Aihara, Daiki; Kanda, Kouhei; Usui, Akihito; Hosokai, Yoshiyuki; Saito, Haruo; Ichiyanagi, Yuko

doi:10.1109/tmag.2018.2845132

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…[1][2][3][4][5][6] Researchers have reported the magnetic, structural, and thermal properties of nanoparticles, including transition metals, and proposed corresponding biomedical applications. [7][8][9][10][11][12][13][14] We also reported the magnetic and thermal properties of various types of MNPs and confirmed a significant hyperthermia effect of MnÀ Zn ferrite nanoparticles using human breast cancer cells. [7] Although hyperthermia treatment is intended for cancer therapy, MNPs may also be useful diagnostic tools.…”

Section: Introductionsupporting

confidence: 61%

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

et al. 2022

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Co1‐xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin‐echo magnetic resonance imaging measurements for Co1‐xMgxFe2O4 nanoparticles using a 0.3‐T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.

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Section: Introductionsupporting

confidence: 61%

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

et al. 2022

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“…During MNP functionalization, efficient coating of the magnetic core is ensured to preserve its surface functionalization (i.e. affinity towards target molecules) [18][19][20][21]. In general, surface coating of MNPs consists of two major approaches.…”

Section: Magnetic Nanoparticle Functionalization and Synthesismentioning

confidence: 99%

Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases

et al. 2022

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High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field of rapid testing and screening, however, are confounded by several technical challenges including material cost, half-life, stability, site-specific targeting, analytes specificity, and detection sensitivity that affect the overall diagnostic potential and therapeutic profile. Despite their advances in point-of-care testing, very few classical biosensors have proven effective and commercially viable in situations of healthcare emergency including the recent COVID-19 pandemic. To overcome these challenges functionalized magnetic nanoparticles (MNPs) have emerged as key players in advancing the biomedical and healthcare sector with promising applications during the ongoing healthcare crises. This critical review focus on understanding recent developments in theranostic applications of functionalized magnetic nanoparticles (MNPs). Given the profound global economic and health burden, we discuss the therapeutic impact of functionalized MNPs in acute and chronic diseases like small RNA therapeutics, vascular diseases, neurological disorders, and cancer, as well as for COVID-19 testing. Lastly, we culminate with a futuristic perspective on the scope of this field and provide an insight into the emerging opportunities whose impact is anticipated to disrupt the healthcare industry. Graphical Abstract

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“…Higuchi model dependents on diffusion and dissolution, dissolution are an important phenomenon in controlled drug release (7). Korsmeyer-Peppas model was employed to determine the type of dissolution, by finding its exponent value n (8). Kinetics models were applied based on two of Fick's law assumptions [43].…”

Section: Application Of Kinetics Modelsmentioning

confidence: 99%

“…Developing new strategies to improve prognosis is the need of the hour, as patients tend to develop resistance against the medicines. Drug resistance inhibits the efficient outcomes in cancer therapy; research works on HER2 (human epidermal growth factor receptor 2) targeted iron oxide holding Cisplatin nanoparticles greatly reduced the ovarian tumour in mice [7, 8]. There are three strategies for targeting cancerous cells: inactive targeting, active targeting, and stimulus‐responsive targeting [9].…”

Section: Introductionmentioning

confidence: 99%

Co‐encapsulating CoFe ₂ O ₄ and MTX for hyperthermia

Saleh

Ahmed

Asad

et al. 2019

IET nanobiotechnol.

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Magnetic manotheranostics can be a fascinating charm to diagnose a tumour with MRI, and treatment through hyperthermia. This study aims to synthesise and characterise magnetically responsive polymer colloids (MRPCs). Healthy tissue damage done by chemotherapy session could be minimised by MRPCs. For the colloidal formulation of MRPCs, the oil in water emulsion technique was employed with the aid of sonication and stirring. The organic phase of emulsion contained methotrexate (MTX) drug, Eudragit E100 and CoFe 2 O 4 (synthesised by co-precipitation) in ethanol, and the aqueous phase contained tween 80 in deionised water. The emulsion was optimised by studying/adjusting two different parameters, i.e. the concentration of constituents and sonication cycles. Multiple formulations were produced at sonication amplitude of 60% at 20 kHz, followed by centrifugation and lyophilisation. Characterisation of MRPCs was done for morphology, size measurement (23-25 nm), surface charge (∼15.12), coercivity (∼1549.6 G), magnetisation (2.6 emu) and retentivity (1.34 emu). Drug release in simulating physiological environment (pH = 7.4), was observed for up to 48 h, and, to determine the best release kinetic mechanism results were compared with kinetic models. Magnetic hyperthermia studies showed that MRPCs achieved an acceptable temperature of 42°C, for hyperthermia treatments in cancer patients.

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Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Cited by 13 publications

References 24 publications

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases

Co‐encapsulating CoFe ₂ O ₄ and MTX for hyperthermia

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Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Cited by 13 publications

References 24 publications

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases

Co‐encapsulating CoFe 2 O 4 and MTX for hyperthermia

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Product

Resources

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Co‐encapsulating CoFe ₂ O ₄ and MTX for hyperthermia