Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro

Sayes, Christie M.; Liang, Feng; Hudson, Jared L.; Mendez, Joe S.; Guo, Wenhua; Beach, Jonathan M.; Moore, Valerie C.; Doyle, Condell D.; West, Jennifer L.; Billups, W. E.; Ausman, Kevin D.; Colvin, Vicki L.

doi:10.1016/j.toxlet.2005.08.011

Cited by 795 publications

(446 citation statements)

References 17 publications

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“…Currently, most of the toxicological evaluations conducted on cultured cells or in vivo support the toxicity of CNTs (Ding and Liu, 2005;Lam et al, 2006) although the antimicrobial response depends on the degree of sidewall functionalization (Sayes et al, 2006). Although the toxicity of CNTs towards prokaryotes may be different than CNT toxicity towards eukaryotes, one study showed that multi-walled carbon nanotubes (MWCNTs) caused cell death and apoptosis with corresponding changes in the protein expression of human skin fibroblasts; however, this study did not conclusively define the mechanism of cell death (Ding and Liu, 2005).…”

Section: Properties Of Carbon Nanutubes and Carboxylated Carbon Nanotmentioning

confidence: 99%

Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal

et al. 2009

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Section: Properties Of Carbon Nanutubes and Carboxylated Carbon Nanotmentioning

confidence: 99%

Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal

et al. 2009

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“…Rendering the surface chemistry or coating may provide an attractive strategy in reducing toxicity. A recent study has shown that increasing the degree of sidewall functionalization decreases the cytotoxicity of single-walled carbon nanotubes (Sayes et al, 2006). However, this may be difficult in some environmental settings or the body.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticulate materials and regulatory policy in Europe: An analysis of stakeholder perspectives

et al. 2006

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The novel properties of nanoparticulate materials (NPM) and the rapid development of NPM based products have raised many unanswered questions and concerns by different stakeholders over its consequences for the environment and human health. These concerns have led to an increasing discussion in both the US and Europe about possible regulatory policies for NPM. In this article a comparative study of stakeholdersÕ perceptions on regulatory policy issues with NPM in Europe is presented. It was found that industry wants to regulate this area if the scientific evidence demonstrates that NPM are harmful, but also that the regulatory bodies do not find it necessary at this point of time to regulate until scientific evidence demonstrates that NPM are harmful. This research therefore shows that there will most likely not be any regulatory interventions until there is an established and convincing scientific knowledge base demonstrating that NPM can be hazardous. It is furthermore discussed in this article the different roles and responsibilities of the stakeholders in financing the research required to establish the necessary level of fundamental scientific evidence. It was also found that the activity of the regulatory bodies on this issue differ between the European countries.

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“…One challenge in using nanomaterials such as QDs for in vivo studies is its potential long-term toxicity and its effect on in vivo fate (Sayes et al, 2006). The toxicity and the potential environmental effects of QDs need to be addressed before these agents can be used for in vivo imaging.…”

Section: Toxicity Of Quantum Dotsmentioning

confidence: 99%

Recent Advances in Nanobiotechnology and High-Throughput Molecular Techniques for Systems Biomedicine

Kim

Ahn

Chung

et al. 2013

Molecules and Cells

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Nanotechnology-based tools are beginning to emerge as promising platforms for quantitative high-throughput analysis of live cells and tissues. Despite unprecedented progress made over the last decade, a challenge still lies in integrating emerging nanotechnology-based tools into macroscopic biomedical apparatuses for practical purposes in biomedical sciences. In this review, we discuss the recent advances and limitations in the analysis and control of mechanical, biochemical, fluidic, and optical interactions in the interface areas of nanotechnologybased materials and living cells in both in vitro and in vivo settings.

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Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro

Cited by 795 publications

References 17 publications

Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal

Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal

Nanoparticulate materials and regulatory policy in Europe: An analysis of stakeholder perspectives

Recent Advances in Nanobiotechnology and High-Throughput Molecular Techniques for Systems Biomedicine

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