Functionalization of 3D-Printed Titanium Scaffolds with Elastin-like Recombinamers to Improve Cell Colonization and Osteoinduction

Guillem-Marti, Jordi; Vidal, Elia; Girotti, Alessandra; Heras-Parets, Aina; Torres, D; Arias, Francisco J.; Ginebra, Maria‐Pau; Rodríguez‐Cabello, José Carlos; Manero, José María

doi:10.3390/pharmaceutics15030872

Cited by 6 publications

(4 citation statements)

References 50 publications

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“…A 3D-printed titanium mesh should have adequate compressive capacity to avoid any probable collapse or displacement during bone defect restoration, ultimately providing appropriate space and mechanical support for new bone growth [30]. Additionally, the favorable metabolism of bone marrow mesenchymal stem cells, growth factors, and other substances that promote osteogenesis require su cient blood supply, leading to extensive use of 3D-printed implants made from titanium and its alloys due to their ability to provide such adequate blood supply [31].…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional printed titanium mesh combined with iliac cancellous bone in the reconstruction of mandibular defects secondary to ameloblastoma resection

Zhao

Shen

et al. 2023

Preprint

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Background The reconstruction of large mandibular defects is a challenge, and the free vascularized bone flaps are most commonly used. However, the precision and symmetry of this repair are deficient, and patients have a risk of vascular embolism, flap necrosis and donor site complications. Therefore, to explore an ideal alternative in mandibular reconstruction with high surgical accuracy and low complications is indispensable. Methods Seven patients with recurrent or large-scope ameloblastoma were enrolled in this study. All patients were provided with a fully digital treatment plan, including the design of osteotomy lines, surgical guides, and three-dimensional printed titanium mesh for implantation. With the assistance of a surgical guide, ameloblastomas were resected, and custom 3D printed titanium mesh combined with posterior iliac bone harvest was used in mandibular reconstruction. The surgical discrepancy between the surgical plan and the real result was compared. At the same time, the resorption rate of the implanted bone was evaluated. Results All patients completed the fully digital treatment process successfully without severe complications. Image fusion showed that the postoperative contour of the mandible was basically consistent with surgical planning, except for a slight increase in the inferior border of the affected side. The mean error between the intraoperative bone volume and the digital planning bone volume was 2.44%±2.10%. Furthermore, the bone resorption rates of the harvested graft 6 months later were 32.15%±6.95%. Conclusions The use of digital surgical planning and 3D-printed templates can assist surgeons in performing precise surgery, and the 3D-printed titanium mesh implant can improve the patient's facial symmetry. 3D printed titanium combined with posterior iliac cancellous bone graft can be regarded as an ideal alternative in extensive mandibular reconstruction.

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Section: Discussionmentioning

confidence: 99%

Three-dimensional printed titanium mesh combined with iliac cancellous bone in the reconstruction of mandibular defects secondary to ameloblastoma resection

Zhao

Shen

et al. 2023

Preprint

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“…Many studies have attempted to improve biocompatibility by surface modifying the 3D printed Ti implants. Some of the surface modifications on Ti scaffolds include the application of a homogeneous layer of microporous TiO 2 and calcium-phosphate [96], genetically modified elastin-like recombinamers (ELRs) containing specific cell adhesive (RGD) and osteoinductive (SNA15) moieties [97], coating of aspirin (ASP)/PLGA [98], titania nanotubes via electrochemical anodization and bioactivation through HA coating [99], and chimeric peptides [100]. Studies on adding antimicrobial properties were carried out by surface coating of the Ti implants with gallium nitrate [101], vancomycin hydrochloride [102], flavonoid quercitrin [103], chitosan (CS)-modified MoS 2 coating loaded with AgNPs [104], and calcium titanate [105], to prevent bacterial adhesion and proliferation on the surface.…”

Section: D Printingmentioning

confidence: 99%

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Appuhamillage,

Ambagaspitiya,

Dassanayake

et al. 2024

Exploration of Medicine

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Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, and textiles. 3D printing, also known as additive manufacturing (AM), allows the fabrication of complex structures with high precision via a layer-by-layer addition of various materials. On the other hand, 4D printing technology enables printing smart materials that can alter their shape, properties, and functions upon a stimulus, such as solvent, radiation, heat, pH, magnetism, current, pressure, and relative humidity (RH). Myriad of biomedical materials (BMMs) currently serve in many biomedical engineering fields aiding patients’ needs and expanding their life-span. 3D printing of BMMs provides geometries that are impossible via conventional processing techniques, while 4D printing yields dynamic BMMs, which are intended to be in long-term contact with biological systems owing to their time-dependent stimuli responsiveness. This review comprehensively covers the most recent technological advances in 3D and 4D printing towards fabricating BMMs for tissue engineering, drug delivery, surgical and diagnostic tools, and implants and prosthetics. In addition, the challenges and gaps of 3D and 4D printed BMMs, along with their future outlook, are also extensively discussed. The current review also addresses the scarcity in the literature on the composition, properties, and performances of 3D and 4D printed BMMs in medical applications and their pros and cons. Moreover, the content presented would be immensely beneficial for material scientists, chemists, and engineers engaged in AM manufacturing and clinicians in the biomedical field. Graphical abstract. 3D and 4D printing towards biomedical applications

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“…Liu et al [126] prepared VEGF/BMP-2 core-shell microspheres using coaxial electrostatic spraying technology and loaded the VEGF/BMP-2 core-shell microspheres onto 3D-printed Ti alloy support scaffolds coated with gelatin polymer, thus achieving the sequential release of VEGF and BMP-2 in a composite scaffold system that can effectively promote bone regeneration, providing experimental support and strategies for bone defect repair. Additionally, Guillem et al [127] functionalized the surface of 3D-printed Ti scaffolds with transgenic elastin-like recombinases (ELRs), and the results showed that the improved surface can enhance bone-bonding ability and regulate cell responses.…”

Section: Biologically Active Organic Coatingsmentioning

confidence: 99%

A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants

Long,

Zhu,

Jing

et al. 2023

Coatings

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The advent of three-dimensional (3D) printing technology has revolutionized the production of customized titanium (Ti) alloy implants. The success rate of implantation and the long-term functionality of these implants depend not only on design and material selection but also on their surface properties. Surface modification techniques play a pivotal role in improving the biocompatibility, osseointegration, and overall performance of 3D-printed Ti alloy implants. Hence, the primary objective of this review is to comprehensively elucidate various strategies employed for surface modification to enhance the performance of 3D-printed Ti alloy implants. This review encompasses both conventional and advanced surface modification techniques, which include physical–mechanical methods, chemical modification methods, bioconvergence modification technology, and the functional composite method. Furthermore, it explores the distinct advantages and limitations associated with each of these methods. In the future, efforts in surface modification will be geared towards achieving precise control over implant surface morphology, enhancing osteogenic capabilities, and augmenting antimicrobial functionality. This will enable the development of surfaces with multifunctional properties and personalized designs. By continuously exploring and developing innovative surface modification techniques, we anticipate that implant performance can be further elevated, paving the way for groundbreaking advancements in the field of biomedical engineering.

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Functionalization of 3D-Printed Titanium Scaffolds with Elastin-like Recombinamers to Improve Cell Colonization and Osteoinduction

Cited by 6 publications

References 50 publications

Three-dimensional printed titanium mesh combined with iliac cancellous bone in the reconstruction of mandibular defects secondary to ameloblastoma resection

Three-dimensional printed titanium mesh combined with iliac cancellous bone in the reconstruction of mandibular defects secondary to ameloblastoma resection

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants

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